Fig. 6
From: Blockade of exosome generation by GW4869 inhibits the education of M2 macrophages in prostate cancer
GW4869 inhibited the differentiation of tumor-associated macrophages into M2 phenotype in vivo. A The effect of GW4869 on the growth of prostate cancer in tumor xenograft mice (n = 5). After the subcutaneous injection of 5 × 106 PC-3-M-1E8 cells or PC-3-M-1E8 cells treated with GW4869 in nude mice, tumor volume was measured every five days, where tumor volume (mm3) = shorter diameter2 × longer diameter/2. B GW4869 reduced number of CD206+ macrophages in PCa tissues. After tumor formation, CD206 expression in tumor tissue was determined using immunohistochemical analysis. *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001, ****p ≤ 0.0001