Fig. 7

Identification of immune gene coexpression modules and prognostic immune hub genes of sarcoma. A Dendrogram of all differentially expressed genes clustered based on a dissimilarity measure (1-TOM). B Gene numbers in each module. C Differential distribution of feature vectors of each module in sarcoma subtypes. ns, not significant, *P < 0.01 and ****P < 0.00001. D Forest maps of univariate Cox regression survival analysis on the PFS of 6 modules in sarcoma. E, F Dot plot showing the top 10 GO terms in the blue (E) and red (F) modules. The dot size and color intensity represent the gene count and enrichment level, respectively. G, H Correlation between the blue (G) and red (H) module feature vectors and PC1 in the immune landscape. I, J Kaplan–Meier curves with log-rank test showing the differential PFS in the 5-gene signature with high and low risk in the datasets TCGA (I) and GSE21050 (J)