Fig. 1
From: Single-cell analysis of immune cell transcriptome during HIV-1 infection and therapy
scRNA-seq of peripheral immune cells identified distinct cellular populations. A Schematic of scRNA-seq experimental procedure using peripheral blood mononuclear cells (PBMC) from 6 untreated chronic HIV-1-infected individuals, 3 ART-treated chronic HIV-1-infected individuals and 3 HIV-1 seronegative individuals resulting in the analysis of 81,235 total PBMC cells. B UMAP analysis of all 81,235 cells and graph-based clustering of cell populations resulted in the identification of 23 transcriptionally distinct clusters. Individual cells are colored by cluster identity. C UMAP analysis with cell colored and labeled by cell identify determined by Azimuth reference. D UMAP analysis with individual cells colored by sample group. E Bar graph showing the fraction of total single cells in each Azimuth defined cell type by group