Fig. 2
From: Single-cell analysis of immune cell transcriptome during HIV-1 infection and therapy
Differentially expressed genes in untreated chronic and ART treated HIV-1-infected compared with HIV-1 seronegative cells. A–B Volcano plot of genes that are significantly (P ≤ 0.05; Wilcoxon rank sum test, Bonferroni adjusted) different when comparing (A) Untreated HIV-1 vs. Seronegative and B ART HIV-1 vs. Seronegative group cells. X-axis displays log2 fold-change of each significant gene. C–D Gene Set Enrichment Analysis (GSEA) of the top enriched biological pathways in genes significantly altered in C untreated HIV-1 or D DART HIV-1. Pathways highlighted in red are present in both groups. GSEA enrichment plot for the Hallmark_Inflammatory_Response feature is shown below each graph