Fig. 3
From: Single-cell analysis of immune cell transcriptome during HIV-1 infection and therapy
Proinflammatory signatures in T cells despite therapy. A UMAP plot identifying T cell clusters that were isolated and reclustered for more high-definition analysis revealing multiple cellular clusters. B UMAP analysis with cell colored and labeled by cell identify determined by Azimuth reference. C UMAP plots of T cell clusters with cells labeled and colored by experimental group. D Bar graph showing the fraction of total single cells in each Azimuth defined cell type by group. E–F Differentially expressed genes in Chronic or ART-treated HIV-1-infection compared to cells from seronegative individuals in E CD4 T cells or F CD8 T cells. Each dot represents a gene and Bonferroni adjusted p value displayed on Y-axis and the Log2 Fold change of expression displayed on the X-axis