Fig. 4
From: Single-cell analysis of immune cell transcriptome during HIV-1 infection and therapy
CD4 T cell activation status and long-noncoding RNAs regulate early HIV-1 infection A overview of primary cell model of HIV-1 infection and scRNA-seq. B UMAP plot of scRNA-seq of T cell data from two independent healthy individuals. Each point represents a single cell. C UMAP analysis with cell colored and labeled by cell identify determined by Azimuth reference. D UMAP plot displaying HIV-1 gag gene expression in the individual cells. E UMAP plots showing expression of transcripts that were significantly upregulated in T cells that had expression of HIV-1 gag compared to cells that lacked expression. F Transcripts that were significantly changed in T cells that had expression of HIV-1 gag compared to cells that laced detectable expression. G Top genes that correlated and anti-correlated (r, Pearson) with HIV-1 gag expression in all cells