Fig. 2

Severe COVID-19 disease is associated with decreased frequencies of DC subsets and circulating levels of Type I and Type III IFN. A The frequencies of DC (pDC and mDC) subsets in mild (n = 30) and severe (n = 15) COVID-19 individuals sampled between days 15 to 60 following RT-PCR confirmation. B Circulating plasma levels of Type I Interferons (IFNα and IFNβ) in mild (n = 30) and severe (n = 15) COVID-19 individuals sampled between days 15 to 60 following RT-PCR confirmation. C Circulating plasma levels of Type III Interferons (IFNλ1, IFNλ2 and IFNλ3) in mild (n = 30) and severe (n = 15) COVID-19 individuals sampled between days 15 to 60 following RT-PCR confirmation. The data are represented as scatter plots with each circle representing a single individual. p values were calculated using the Mann– Whitney U-test