Fig. 3

Low frequencies of Bregs were associated with an increased risk of septic shock development in patients with sepsis. A The Bregs in sepsis patients that did not develop septic shock versus those that developed septic shock. B The absolute count of Bregs in sepsis patients that did not develop septic shock versus those that developed septic shock. C Fraction of septic shock patients in Bregs high (%Bregs > 2.204%) patients versus that in Bregs low (%Bregs < 2.204%) patients. D Frequency and F absolute number of Bregs in sepsis patients versus septic shock patients, subdivided into bacterial, viral and fungal types. Two-tailed t test with unequal variance or Kruskal–Wallis test. *p < 0.05