Fig. 2

CD206 staining in patients with active AGN. A, B Images depict representative high-power views of paraffin-embedded human kidney sections of disease control (A) and active vasculitis (B). CD206 were stained by immunohistochemistry. No positive staining for CD206 were found in the disease control (A). C Histograms of CD206 staining areas in the glomeruli from patients with AGN (n = 10) and disease control (n = 6). Paraffin-embedded human kidney sections from patients with vasculitis were stained for CD206 protein by immunohistochemistry and scored blind according to the location of cells with each of four regions: (1) within regions of fibrinoid necrosis or crescent formation, (2) within regions of glomeruli, (3) in the periglomerular region, (4) within tubulointerstitial compartment. Dots represented for the scores from different regions and error bars represented for the standard deviation (SD). The results showed that compared with disease controls, CD206 scores were significant higher in regions of fibrinoid necrosis or crescent formation (2.80 ± 0.32 vs 0); periglomerular region (1.63 ± 0.94 vs 0.06 ± 0.14), tubulointerstitial compartment (2.60 ± 0.58 vs 0.11 ± 0.27) and glomeruli (2.70 ± 0.64 vs 0.22 ± 0.40) in AGN patients. #p < 0.01