Regulatory and effector T cell subsets in tumor-draining lymph nodes of patients with squamous cell carcinoma of head and neck

Table 1 Percentages of CD4⁺ and CD8⁺ T cells and their subsets in the TDLNs of HNSCC patients

Cell subset	Min	Max	Median	Mean ± SD
CD4⁺	24.8	75.4	45.5	46.3 ± 10.5
CD4T cell subsets
CD4⁺ TNF-α⁺	7.9	86.1	63.6	57.3 ± 16.3
CD4⁺TNF-α^hi	2.7	54.6	38.3	35.7 ± 13.2
CD4⁺TNF-α^low	5.2	39.8	21.6	21.2 ± 6.4
CD4⁺IFN-γ⁺	0.6	14.2	3.2	3.8 ± 2.7
CD4⁺IFN-γ⁺TNF-α⁺	0.4	14	3.2	3.6 ± 2.6
CD4⁺IFN-γ⁺TNF-α⁻	0.0	0.8	0.1	0.18 ± 0.17
CD4⁺IL-10⁺	0.2	4.5	0.7	0.9 ± 0.7
CD4⁺IL-17⁺	0.4	4.1	1.3	1.4 ± 0.9
CD4⁺IL-4⁺	0.4	5.8	2.2	2.3 ± 1.3
CD4⁺TGF-β⁺	0.3	50.6	28.6	27.4 ± 11.2
CD4⁺CD25⁺FOXP3⁺	2.7	14.6	5.6	6.4 ± 2.7
CD4⁺CD25⁺FOXP3⁺CD127^low	1.2	12.3	4.6	5.3 ± 2.5
CD4⁺CD25⁻FOXP3⁺	0.7	9.6	1.4	2.2 ± 1.8
CD4⁺CD25⁻FOXP3⁺CD127^low	0.5	7.2	1	1.5 ± 1.2
CD8⁺	2.6	16.7	8.5	8.6 ± 3.7
CD8⁺ T cell subsets
CD8⁺ TNF-α⁺	6.9	81.9	43.7	42.4 ± 17.2
CD8⁺IFN-γ⁺	2.1	64.4	20.5	23.6 ± 14.8
CD8⁺IL-10⁺	0.1	2.1	0.7	0.8 ± 0.5
CD8⁺IL-17⁺	0.1	6.2	0.6	1.0 ± 1.2
CD8⁺IL-4⁺	0.3	15.2	2.5	3.4 ± 3.1
CD8⁺TGF-β⁺	4.6	38	18.7	18.8 ± 8.1

TDLN, tumor draining lymph node; SD, standard deviation; hi, high; TNF-α, tumor necrosis factor alpha; IFN-γ, interferon gamma; TGF-β, transforming growth factor beta

ISSN: 1471-2172