DDX1 is a prognostic biomarker and correlates with immune infiltrations in hepatocellular carcinoma

BMC Immunology

Table 2 Univariate and multivariate Cox regression analyses of clinical characteristics associated with overall survival

Characteristics	Total (N)	Univariate analysis		Multivariate analysis
Characteristics	Total (N)	Hazard ratio (95% CI)	P value	Hazard ratio (95% CI)	P value
Age	373
≤ 60	177	Reference
> 60	196	1.205 (0.850–1.708)	0.295
Gender	373
Female	121	Reference
Male	252	0.793 (0.557–1.130)	0.200
Pathologic stage	349
Stage I & Stage II	259	Reference
Stage III & Stage IV	90	2.504 (1.727–3.631)	< 0.001	1.341 (0.182–9.864)	0.773
Histologic grade	368
G1&G2	233	Reference
G3&G4	135	1.091 (0.761–1.564)	0.636
DDX1	373
Low	186	Reference
High	187	1.628 (1.145–2.313)	0.007	1.822 (1.139–2.915)	0.012
AFP(ng/ml)	279
≤ 400	215	Reference
> 400	64	1.075 (0.658–1.759)	0.772
T stage	370
T1&T2	277	Reference
T3&T4	93	2.598 (1.826–3.697)	< 0.001	1.833 (0.248–13.569)	0.553
N stage	258
N0	254	Reference
N1	4	2.029 (0.497–8.281)	0.324
M stage	272
M0	268	Reference
M1	4	4.077 (1.281–12.973)	0.017	1.856 (0.427–8.075)	0.410
Child-Pugh grade	240
A	218	Reference
B&C	22	1.643 (0.811–3.330)	0.168
Residual tumor	344
R0	326	Reference
R1&R2	18	1.604 (0.812–3.169)	0.174
Tumor status	354
Tumor free	202	Reference
With tumor	152	2.317 (1.590–3.376)	< 0.001	1.873 (1.172–2.995)	0.009

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