Fig. 1

Percentage of Tregs subtypes with or without TGFBR2 mutations. Tregs were defined as CD4⁺CD25^hiFoxp3⁺ cells. Treg compartments, namely aTreg, rTreg, and nsTreg, were further defined as Foxp3^hiCD45RA⁻, Foxp3^intCD45RA⁺, and Foxp3^intCD45RA⁻ cells, respectively among Tregs. A Representative flow plot of CD4⁺CD25⁺ T cells and Tregs subsets. B Percentage of CD4⁺CD25⁺ T cells and Tregs subsets in CD4⁺ T cells in ITP patients with and without TGFBR2 mutations. C Percentage of Tregs subsets in CD4⁺CD25⁺ T cells in ITP patients with and without TGFBR2 mutations. D Percentage of CD4⁺CD25⁺ T cells and Tregs subsets in CD4⁺ T cells among the ITP patients with V216I mutation, with T340M mutation and wild type. E Percentage of Tregs subsets in CD4⁺CD25⁺ T cells among ITP patients with V216I mutation, with T340M mutation and wild type