Table 2 Demographic characteristics and Treg plasticity of primary ITP patients
|  | All ITP (n = 92) | Health control (n = 12) | p value | Onset 18–49 years (n = 48) | Onset over 50 years (n = 44) | p value |
|---|---|---|---|---|---|---|
Female sex, n (%) | 64 (69.6) | 8 (66.7) | 0.838 | 38 (79.2) | 26 (59.1) | 0.037 |
Age, years | 48 ± 19 | 42 ± 14 | 0.272 | 33 ± 8 | 65 ± 10 | < 0.001 |
Platelet count, × 109/L | 14 ± 7 | 205 ± 42 | < 0.001 | 12 ± 8 | 16 ± 8 | 0.359 |
Response, n (%) | Â | Â | Â | Â | Â | Â |
 CR | 44 (47.8) | NA | NA | 26 (54.2) | 18 (40.9) | 0.206 |
 PR | 32 (34.8) | NA | NA | 15 (31.3) | 17 (38.6) | 0.457 |
 NR | 16 (17.4) | NA | NA | 7 (14.6) | 9 (20.5) | 0.458 |
TGFBR2 variants, n (%) | 7 (7.6) | NA | NA | 1 (2.1) | 6 (13.6) | 0.037 |
Positive ANA, n (%) | 25 (27.2) | NA | NA | 13 (27.1) | 12 (27.3) | 0.984 |
Lymphocyte subgroups, % | Â | Â | Â | Â | Â | Â |
 CD19+ | 19 ± 8 | 19 ± 5 | 0.962 | 21 ± 6 | 16 ± 10 | 0.053 |
 CD3+CD4+ | 36 ± 9 | 39 ± 6 | 0.418 | 35 ± 8 | 37 ± 11 | 0.389 |
 CD3+CD8+ | 27 ± 10 | 23 ± 5 | 0.175 | 26 ± 4 | 27 ± 14 | 0.672 |
 CD16+CD56+ | 13 ± 7 | 11 ± 3 | 0.143 | 12 ± 7 | 14 ± 7 | 0.591 |
Tregs, % | Â | Â | Â | Â | Â | Â |
 CD4+CD25hiFoxp3+ | 1.2 ± 0.9 | 1.1 ± 0.3 | 0.697 | 1.1 ± 0.9 | 1.2 ± 0.9 | 0.792 |
 CD4+CD25hiFoxp3+IFN-γ+ | 8.2 ± 5.0 | 23.2 ± 5.5 | < 0.001 | 7.3 ± 5.4 | 8.3 ± 4.8 | 0.605 |
 CD4+CD25hiFoxp3+IL-13+ | 7.4 ± 4.6 | 11.8 ± 4.7 | 0.007 | 7.3 ± 5.1 | 7.4 ± 4.5 | 0.966 |
 CD4+CD25hiFoxp3+IL-17+ | 12.9 ± 9.4 | 3.5 ± 1.4 | 0.005 | 5.2 ± 3.0 | 16.9 ± 13.8 | 0.017 |