Table 3 Upregulated pathways in the MmNOl cells cultivated at 5Â \(^\circ\)C compared to the 37Â \(^\circ\)C cultivated controls
Pathway name | \(p_\text{FDR}\) |
|---|---|
rRNA processing in the nucleus and cytosol | 1.63E-13 |
Major pathway of rRNA processing in the nucleolus and cytosol | 2.17E-13 |
rRNA processing | 2.17E-13 |
rRNA modification in the nucleus and cytosol | 1.69E-10 |
Response of EIF2AK4 (GCN2) to amino acid deficiency | 1.95E-06 |
Translation | 3.39E-06 |
Metabolism of RNA | 6.24E-04 |
Cellular response to starvation | 1.22E-03 |
SRP-dependent cotranslational protein targeting to membrane | 3.55E-03 |
GTP hydrolysis and joining of the 60S ribosomal subunit | 3.55E-03 |
L13a-mediated translational silencing of Ceruloplasmin expression | 3.55E-03 |
Nonsense Mediated Decay (NMD) independent of the EJC | 3.55E-03 |
Eukaryotic Translation Elongation | 3.81E-03 |
Peptide chain elongation | 4.08E-03 |
Eukaryotic Translation Initiation | 4.08E-03 |
Cap-dependent Translation Initiation | 4.08E-03 |
Formation of a pool of free 40S subunits | 5.04E-03 |
Eukaryotic Translation Termination | 5.04E-03 |
Collagen formation | 9.17E-03 |
Selenocysteine synthesis | 1.05E-02 |
Syndecan interactions | 1.06E-02 |
Response of EIF2AK1 (HRI) to heme deficiency | 1.06E-02 |
Mitochondrial translation elongation | 1.13E-02 |
Mitochondrial translation termination | 1.13E-02 |
Collagen biosynthesis and modifying enzymes | 1.26E-02 |
Mitochondrial translation | 1.26E-02 |
Nonsense-Mediated Decay (NMD) | 1.44E-02 |
Nonsense Mediated Decay (NMD) enhanced by the EJC | 1.44E-02 |
PERK regulates gene expression | 1.51E-02 |
IGF-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA | 1.56E-02 |
Viral mRNA Translation | 2.07E-02 |
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 2.35E-02 |
Mitochondrial translation initiation | 2.60E-02 |
Non-integrin membrane-ECM interactions | 4.67E-02 |