Table 1 Summary of the observational studies assessed the relationship between serum vitamin D and inflammatory /oxidative biomarkers in pregnant women
First Author, year | Design | Location | Participants | Health condition | Gestational age (week) | Outcome/Exposure | Quality appraisal |
|---|---|---|---|---|---|---|---|
Nassr, 2022 | Cohort | Baghda, Iraq | n= 80 | Healthy | 28–39 | 25-OH-D, CRP | Very good |
Otilia Perichart-Perera, 2022 | Cohort | Mexico, Mexico City | SGA (n = 14) AGA (n = 63) | SGA | NI | 25-OH-D, MDA, TAC, HbA1c | Very good |
Lisnawati, 2021 | Cross-Sectional | Indonesia, Jakarta | Maternal 25(OH)D (ng/mL): Normal (n = 22); Insufficiency (n = 42); Deficiency (n = 6) | Preterm birth | 28–34 | serum vitamin D of the maternal and umbilical cord, umbilical cord IL-6, and serum CRP in premature infants | Satisfactory |
Yaqiong, 2020 | Cross-Sectional | China, Lianyungang City | Case (n = 110) Control (n = 100) | GDM | NI | 25(OH)D, hs-CRP, TNF-α in maternal serum | Good |
Jin, 2020 | Prospective Birth Cohort | China, Hefei | n = 2479 | Healthy | second trimester (14–27) | 25(OH)D, hs-CRP in maternal serum | Good |
Budhwar, 2020 | Case-Control | India, Varanasi | Cord blood of pre-term babies (n = 20) Cord blood of term babies (n = 20) | Pre-term birth | The case group: 27–36 wk The control group: >37 wk | 25(OH)D, S100A8, HMGB1, TLR2, NF-kappa B in cord blood serum | Satisfactory |
Mousa, 2017 | Baseline Data of a RCT | Australia, Melbourne | n = 102 | Overweight or obese pregnant women at high-risk of GDM | 12–15 | 25(OH)D, IL-6, in maternal serum | Very good |
Rosendahl, 2017 | Baseline data of a Trial | Finland, Helsinki | cord blood of healthy term infants (n = 939) | Healthy | at birth | 25(OH)D, hs-CRP, in cord blood plasma | Very good |
Adela, 2017 | Cross-sectional | India, Hyderabad | Case: n = 30 Control: n = 30 | HDP | Case:33–37 Control: >24 | 25(OH) D3, 1,25(OH)2 D3, 25(OH)D2, and 1,25(OH)2 D2, IL-1β, IL-2, IL-4, IL-5, Il-6, IL-7, IL-8, IL-9, IL-10, IL-12, IL-13, IL-15, IL-17, IFN-γ, TNF-α in maternal serum | Very good |
Pourghassem Gargari, 2016 | Case-Control | Iran, Tabriz | Case (n = 40) Control (n = 40) | PE | ≥ 31 | 25(OH)D, hs-CRP, MDA, TAC in maternal serum | Good |
Haidari, 2016 | Case-Control | Iran, Ahvaz | Case (n = 45) Control (n = 45) | GDM | 20–30 | 25(OH)D, hs-CRP, TNF-α in maternal serum | very good |
Bobbitt, 2015 | Cohort | USA, Detroit | n = 178 | Healthy | 13–28 (The mean gestational age at 25-OHD measure was 9.9 ± 3.6 wk, and mean gestational age at inflammation measurement was 21.1 ± 3.7 wk) | hs-CRP, IL-6, IL-10, IL-1 α and TNF-α in the maternal serum | Very good |
McManus, 2014 | Case-control | Canada, London | Case (n = 36) Controls (n = 37) | GDM | 31 | 25(OH)D, CRP, PAI-1, IL-8 TNF-α, resistin in maternal and cord blood serum | Satisfactory |
Xu, 2014 | Retrospective cohort | USA, Pennsylvania | case (n = 100) control (n = 100) | PE | 35 | 25(OH)D, IL-6 in maternal plasma | Good |