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  1. The synergistic effect of chemoradiation (CRT) has been previously demonstrated in several cancer types. Here, we investigated the systemic immune effects of CRT in patients with lung or head and neck cancer.

    Authors: Jihane Boustani, Elodie Lauret Marie Joseph, Etienne Martin, Salim Benhmida, Benoit Lecoester, Florent Tochet, Céline Mirjolet, Cédric Chevalier, David Thibouw, Noémie Vulquin, Stéphanie Servagi, Xushan Sun and Olivier Adotévi
    Citation: BMC Immunology 2021 22:38
    Content type: Research Published on:

  2. Chronic inflammatory diseases, including diabetes and cardiovascular disease, are heterogeneous and often co-morbid, with increasing global prevalence. Uncontrolled type 2 diabetes (T2D) can result in severe i...

    Authors: Sarah E. Kleinstein, Jamison McCorrison, Alaa Ahmed, Hatice Hasturk, Thomas E. Van Dyke and Marcelo Freire
    Citation: BMC Immunology 2021 22:37
    Content type: Research article Published on:

  3. Some long-term non-progressors (LTNPs) have decreasing CD4+ T cell counts and progress to AIDS. Exploring which subsets of CD4+ T cell decreasing and the determinants associated with the decay in these patients w...

    Authors: Ling Xu, Yubin Liu, Xiaojing Song, Yanling Li, Yang Han, Ting Zhu, Wei Cao and Taisheng Li
    Citation: BMC Immunology 2021 22:36
    Content type: Research Published on:

  4. Mast cells (MCs) are known to contribute to both acute and chronic inflammation. Bronchial epithelial cells are the first line of defence against pathogens and a deficient anti-viral response has been suggeste...

    Authors: Sangeetha Ramu, Hamid Akbarshahi, Sofia Mogren, Frida Berlin, Samuel Cerps, Mandy Menzel, Morten Hvidtfeldt, Celeste Porsbjerg, Lena Uller and Cecilia K. Andersson
    Citation: BMC Immunology 2021 22:35
    Content type: Research article Published on:

  6. The cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) is widely considered as a pivotal immune checkpoint molecule to suppress antitumor immunity. However, the significance of soluble CTLA-4 (sCTLA-4) remai...

    Authors: Jiajia Liu, Xiaoyi Tian, Yan Wang, Xixiong Kang and Wenqi Song
    Citation: BMC Immunology 2021 22:33
    Content type: Research Published on:

  7. Macrophages play prominent roles in bacteria recognition and clearance, including Borrelia burgdorferi (Bb), the Lyme disease spirochete. To elucidate mechanisms by which MyD88/TLR signaling enhances clearance of...

    Authors: Sarah J. Benjamin, Kelly L. Hawley, Paola Vera-Licona, Carson J. La Vake, Jorge L. Cervantes, Yijun Ruan, Justin D. Radolf and Juan C. Salazar
    Citation: BMC Immunology 2021 22:32
    Content type: Research article Published on:

  8. Common variable immunodeficiency (CVID) is an inborn errors of immunity, that leads to recurrent chronic infections and autoimmune/ inflammatory diseases and neoplasms. It is considered that these condition is...

    Authors: Itana Gomes Alves Andrade, Fabíola Isabel Suano de Souza, Fernando Luiz Affonso Fonseca, Carolina Sanchez Aranda and Roseli Oselka Saccardo Sarni
    Citation: BMC Immunology 2021 22:31
    Content type: Research Published on:

  9. Triggering receptor expressed on myeloid cells 2 (TREM2) signaling is considered to regulate anti-inflammatory responses in macrophages, dendritic cell maturation, osteoclast development, induction of obesity,...

    Authors: Hwa-Youn Lee, Eun-Hee Lee, Jawoon Yi, Kon-Young Ji, Su-Man Kim, Ha-Rim Choi, Su-Min Yee, Hyung-Sik Kang and Eun-Mi Kim
    Citation: BMC Immunology 2021 22:30
    Content type: Research Published on:

  11. Preterm birth (PTB) is one of the major causes of neonatal morbidity and mortality worldwide. It is commonly accepted that the act of giving birth is the final step in a proinflammatory signaling cascade, orch...

    Authors: João Mendes, Paulo Rodrigues-Santos, Ana Luísa Areia, Jani-Sofia Almeida, Vera Alves, Manuel Santos-Rosa and Anabela Mota-Pinto
    Citation: BMC Immunology 2021 22:28
    Content type: Research Published on:

  12. Food proteins differ in their allergenic potential. Currently, there is no predictive and validated bio-assay to evaluate the allergenicity of novel food proteins. The objective of this study was to investigat...

    Authors: Mark Smits, Marjolein Meijerink, Thuy-My Le, André Knulst, Aard de Jong, Martinus Petrus Maria Caspers, Everton Souto Lima, Lilia Babé, Gregory Ladics, Scott McClain, Geert Houben and Kitty Verhoeckx
    Citation: BMC Immunology 2021 22:27
    Content type: Research article Published on:

  13. Cytotoxic Natural Killer (NK) cells are increasingly recognized as a powerful tool to induce targeted cell death in cancer and autoimmune diseases. Still, basic blood NK cell parameters are poorly defined. The...

    Authors: Wolfgang Merkt, Ulrich Salzer, Jens Thiel, Ilona Jandova, Raoul Bergner, Ana C. Venhoff and Nils Venhoff
    Citation: BMC Immunology 2021 22:26
    Content type: Research article Published on:

  14. T cell immunoglobulin and mucin domain-containing-3 (Tim-3) is a negative regulator expressed on T cells, and is also expressed on natural killer (NK) cells. The function of Tim-3 chiefly restricts IFNγ-produc...

    Authors: Xiaowen Yu, Bin Lang, Xi Chen, Yao Tian, Shi Qian, Zining Zhang, Yajing Fu, Junjie Xu, Xiaoxu Han, Haibo Ding and Yongjun Jiang
    Citation: BMC Immunology 2021 22:25
    Content type: Research article Published on:

  15. Glucocorticoids (GCs) have been extensively used as essential modulators in clinical infectious and inflammatory diseases. The GC receptor (GR) is a transcription factor belonging to the nuclear receptor famil...

    Authors: Wen-Teng Chang, Ming-Yuan Hong, Chien-Liang Chen, Chi-Yuan Hwang, Cheng-Chieh Tsai and Chia-Chang Chuang
    Citation: BMC Immunology 2021 22:24
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Immunology 2021 22:45

  16. Lipopolysaccharide (LPS) is an endotoxin and a vital component of gram-negative bacteria’s outer membrane. During gram-negative bacterial sepsis, LPS regulates osteoclast differentiation and activity, in addit...

    Authors: Mohammed S. AlQranei, Linda T. Senbanjo, Hanan Aljohani, Therwa Hamza and Meenakshi A. Chellaiah
    Citation: BMC Immunology 2021 22:23
    Content type: Research article Published on:

  17. The spread of a novel coronavirus termed severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in China and other countries is of great concern worldwide with no effective vaccine. This study aimed to d...

    Authors: Yassir A. Almofti, Khoubieb Ali Abd-elrahman and Elsideeq E. M. Eltilib
    Citation: BMC Immunology 2021 22:22
    Content type: Research article Published on:

  18. Differential polarization of macrophage into M1 and M2 mediates atherosclerotic plaque clearance through efferocytosis. Higher expression of Mer proto-oncogene tyrosine kinase (MerTK) on M2 macrophage helps in...

    Authors: Fatin Najiah Mohd Idrus, Nurul Shuhadah Ahmad, Chee Hock Hoe, Maryam Azlan, Farisha Alia Norfuad, Zurkurnai Yusof, Wan Yus Haniff Wan Isa, Akbar Ali Mohamed Ali and Get Bee Yvonne-Tee
    Citation: BMC Immunology 2021 22:21
    Content type: Research article Published on:

  19. Bacillus ancthracis causes cutaneous, pulmonary, or gastrointestinal forms of anthrax. B. anthracis is a pathogenic bacterium that is potentially to be used in bioterrorism because it can be produced in the form ...

    Authors: Jun Ho Jeon, Yeon Hee Kim, Kyung Ae Kim, Yu-Ri Kim, Sun-Je Woo, Ye Jin Choi and Gi-eun Rhie
    Citation: BMC Immunology 2021 22:20
    Content type: Research article Published on:

  20. We aimed to report the clinical characteristics, immunological features, and treatment of one patient with a de novo STAT3 gain-of-function mutation identified by next generation sequencing. We investigated th...

    Authors: Wenjie Wang, Luyao Liu, Xiaoying Hui, Ying Wang, Wenjing Ying, Qinhua Zhou, Jia Hou, Mi Yang, Bijun Sun, Jinqiao Sun and Xiaochuan Wang
    Citation: BMC Immunology 2021 22:19
    Content type: Research article Published on:

  22. Kawasaki disease is an autoimmune disease characterized by systemic vasculitis of unknown aetiology and most commonly occurs in children under 5 years old. Previous studies have found that the over-activation ...

    Authors: Qian Wu, Ruohang Weng, Yongbin Xu, Linlin Wang, Yanyan Huang and Jun Yang
    Citation: BMC Immunology 2021 22:17
    Content type: Research article Published on:

  23. Behcet’s disease (BD) is a relapsing systemic vascular autoimmune/inflammatory disease. Despite much effort to investigate BD, there are virtually no unique laboratory markers identified to help in the diagnos...

    Authors: Linlin Cheng, Yang Li, Ziyan Wu, Liubing Li, Chenxi Liu, Jianhua Liu, Jiayu Dai, Wenjie Zheng, Fengchun Zhang, Liujun Tang, Xiaobo Yu and Yongzhe Li
    Citation: BMC Immunology 2021 22:16
    Content type: Research article Published on:

  24. Immunogenicity is a major challenge in drug development and patient care. Clinicians and regulators are familiar with immunogenicity concerns of monoclonal antibody (mAb) therapeutics, growth factors and enzym...

    Authors: Lobna Abdel Aziz Kilany, Ayman Abdel Samie Gaber, Mohammad Mabrouk Aboulwafa and Hamdallah Hafez Zedan
    Citation: BMC Immunology 2021 22:15
    Content type: Research article Published on:

  25. SARS-CoV-2 is a novel coronavirus first recognized in late December 2019 that causes coronavirus disease 19 (COVID-19). Due to the highly contagious nature of SARS-CoV-2, it has developed into a global pandemi...

    Authors: Xuzhen Qin, Jun Shen, Erhei Dai, Haolong Li, Guodong Tang, Lixia Zhang, Xin Hou, Minya Lu, Xian Wu, Simeng Duan, Jingjia Zhang, Man-Fung Tsoi, Ping Jiang and Yongzhe Li
    Citation: BMC Immunology 2021 22:14
    Content type: Research article Published on:

  26. CD100 is an immune semaphorin family member that highly expressed on T cells, which take part in the development of acute myocardial infarction (AMI). Matrix metalloproteinases (MMPs) are important mediators fo.....

    Authors: Yan Li, Li Qin, Qijun Bai, Jingjing Zhang, Ruixue Chen and Kunpeng Song
    Citation: BMC Immunology 2021 22:13
    Content type: Research article Published on:

  27. NET (neutrophil extracellular trap) has been shown to directly influence inflammation; in SLE (systemic lupus erythematosus), it is reportedly a plausible cause for the broken self-tolerance that contributes t...

    Authors: Alimohammad Fatemi, Razieh Alipour, Hossein Khanahmad, Fereshteh Alsahebfosul, Alireza Andalib and Abbasali Pourazar
    Citation: BMC Immunology 2021 22:12
    Content type: Research Published on:

  29. This study investigates the effect of autologous bone marrow transfusion (BMT) on the reconstruction of both bone marrow and the immune system in patients with AIDS-related lymphoma (ARL).

    Authors: Yixuan Liu, Suhong Xie, Lei Li, Yanhui Si, Weiwei Zhang, Xin Liu, Lin Guo, Baochi Liu and Renquan Lu
    Citation: BMC Immunology 2021 22:10
    Content type: Research article Published on:

  30. Understanding immune mechanisms, particularly the role of innate immune markers during latent TB infection remains elusive. The main objective of this study was to evaluate mRNA gene expression patterns of tol...

    Authors: Birhan Alemnew, Soren T. Hoff, Tamrat Abebe, Markos Abebe, Abraham Aseffa, Rawleigh Howe and Liya Wassie
    Citation: BMC Immunology 2021 22:9
    Content type: Research Published on:

  32. Neutrophils are key components of the exacerbated inflammation and tissue damage in cystic fibrosis (CF) airways. Neutrophil extracellular traps (NETs) trap and kill extracellular pathogens. While NETs are abu...

    Authors: Samantha L. Tucker, Demba Sarr and Balázs Rada
    Citation: BMC Immunology 2021 22:7
    Content type: Research article Published on:

  33. It is important to expound the opposite clinical outcomes between children and adulthood for eradicate malaria. There remains unknown about the correlation between adaptive immune response and age-related in m...

    Authors: Qiu-bo Wang, Yun-ting Du, Fei Liu, Xiao-dan Sun, Xun Sun, Guang Chen, Wei Pang and Ya-Ming Cao
    Citation: BMC Immunology 2021 22:6
    Content type: Research article Published on:

  34. Recent outbreaks of Zika Virus (ZIKV) infection and associated microcephaly has raised multiple scientific questions. The close antigenic relatedness between flaviviruses makes diagnosis of specific infection ...

    Authors: Himanshu Garg, Rose Yeh, Douglas M. Watts, Tugba Mehmetoglu-Gurbuz, Robert Resendes, Bruce Parsons, Fernando Gonzales and Anjali Joshi
    Citation: BMC Immunology 2021 22:5
    Content type: Research article Published on:

  35. No reliable biological marker for the diagnosis of asthma in younger children is currently available. In this study, we analyzed the differences in basophil activation test (BAT) results among children with re...

    Authors: Jingyang Li, Jinhong Wu, Haipei Liu, Li Hua, Quanhua Liu, Dingzhu Fang, Yi Chen, Ruoxu Ji, Jianhua Zhang and Wenwei Zhong
    Citation: BMC Immunology 2021 22:4
    Content type: Research Published on:

  36. Tumor-associated dendritic cells (TADCs) can interact with tumor cells to suppress anti-tumor T cell immunity. However, there is no information on whether and how TADCs can modulate programmed death-ligand 1 (...

    Authors: Weigang Xiu and Jingjing Luo
    Citation: BMC Immunology 2021 22:3
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Immunology 2021 22:18

  38. Systemic lupus erythematosus is an autoimmune disease characterized by an overproduction of autoantibodies resulting from dysregulation in multiple immune cell types. D-mannose is a C− 2 epimer of glucose that ex...

    Authors: Haiting Wang, Xiangyu Teng, Georges Abboud, Wei Li, Shuang Ye and Laurence Morel
    Citation: BMC Immunology 2021 22:1
    Content type: Research article Published on:

  39. C1q is a soluble pattern recognition protein that regulates multiple leukocyte functions, and deficiency in C1q results in autoimmunity. C1q stimulates enhanced phagocytic function through multiple mechanisms ...

    Authors: Emily A. Willmann, Vesna Pandurovic, Anna Jokinen, Danielle Beckley and Suzanne S. Bohlson
    Citation: BMC Immunology 2020 21:61
    Content type: Research Published on:

  40. The forkhead box protein 3 (FOXP3) transcription factor is one of the main markers of immunological suppression in different pathological profiles, and the presence of polymorphic variants may alter the gene e...

    Authors: Leonn Mendes Soares Pereira, Max Willy da Silva Madureira, Renata Bezerra Hermes de Castro, Isabella Nogueira Abreu, Simone Regina Souza da Silva Conde, Sâmia Demachki, Maisa Silva de Sousa, Maria Alice Freitas Queiroz, Andrea Nazaré M. Rangel da Silva, Sandra Souza Lima, Marluísa de Oliveira Guimarães Ishak, Ricardo Ishak and Antonio Carlos Rosário Vallinoto
    Citation: BMC Immunology 2020 21:60
    Content type: Research article Published on:

  41. Brucellar spondylitis (BS) is one of the most serious complications of brucellosis. CXCR3 is closely related to the severity of disease infection. This research aimed to study the degree of BS inflammatory dam...

    Authors: Xin Hu, Xiaoqian Shang, Liang Wang, Jiahui Fan, Yue Wang, Jie Lv, Shaxika Nazierhan, Hao Wang, Jing Wang and Xiumin Ma
    Citation: BMC Immunology 2020 21:59
    Content type: Research article Published on:

  42. The immunosuppressive effects of regulatory B-cells (Bregs) and their immunosuppressive cytokines on immune responses in autoimmune disorders, mainly systemic lupus erythematosus (SLE), have been recently esta...

    Authors: Mitra Abbasifard, Zahra Kamiab, Mohammad Hasani, Amir Rahnama, Pooya Saeed-Askari and Hossein Khorramdelazad
    Citation: BMC Immunology 2020 21:58
    Content type: Research article Published on:

  43. Extracellular vesicles (EVs) are nano-sized particles secreted by most cells. EVs carry nucleic acids that hold promise as potential biomarkers in various diseases. Human immunodeficiency virus type 1 (HIV) in...

    Authors: Sukrutha Chettimada, David R. Lorenz, Vikas Misra, Steven M. Wolinsky and Dana Gabuzda
    Citation: BMC Immunology 2020 21:57
    Content type: Research article Published on:

  44. Pregnancy-specific β1-glycoproteins are capable of regulating innate and adaptive immunity, exerting predominantly suppressive effects. In this regard, they are of interest in terms of their pharmacological po...

    Authors: Valeria P. Timganova, Svetlana A. Zamorina, Larisa S. Litvinova, Natalia M. Todosenko, Maria S. Bochkova, Pavel V. Khramtsov and Mikhail B. Rayev
    Citation: BMC Immunology 2020 21:56
    Content type: Research article Published on:

  45. Numerous investigations have previously evaluated the association of interleukin (IL) 4 gene polymorphisms and the risk of asthma, conferring inconsistent results. To resolve the incongruent outcomes yielded from...

    Authors: Ahmad Kousha, Armita Mahdavi Gorabi, Mehdi Forouzesh, Mojgan Hosseini, Markov Alexander, Danyal Imani, Bahman Razi, Mohammad Javad Mousavi, Saeed Aslani and Haleh Mikaeili
    Citation: BMC Immunology 2020 21:55
    Content type: Research article Published on:

  46. Corticosteroids (CS)s suppress cytokine production and induce apoptosis of inflammatory cells. Prednisone and dexamethasone are oral CSs prescribed for treating asthma exacerbations. While prednisone is more c...

    Authors: Alexander Luchak, Lauren A. Solomon, Tharsan Kanagalingam, Meerah Vijeyakumaran, Brian H. Rowe and Lisa Cameron
    Citation: BMC Immunology 2020 21:54
    Content type: Research article Published on:

  47. Henoch-Schonlein purpura (HSP) is the most common systemic vasculitis of the childhood. However, its mechanisms and pathogenesis still need more exploration. Natural killer (NK) cells are innate lymphocytes, a...

    Authors: Wenjia Chai, Xiaolin Wang, Wei Wang, Hui Wang, Wenjun Mou and Jingang Gui
    Citation: BMC Immunology 2020 21:53
    Content type: Research article Published on:

  48. Previous studies have shown that tuberculosis (TB) is a risk factor for chronic airflow limitation. Chronic obstructive pulmonary disease (COPD) is recognized as the result of chronic inflammation, usually rel...

    Authors: Elise Guiedem, Eric Walter Pefura-Yone, George Mondinde Ikomey, Céline Nguefeu Nkenfou, Martha Mesembe, Mbanyamsig Mispa Yivala, Bih Hycenta Chendi, Graeme Brendon Jacobs, Novel Njweipi Chegou and Marie Claire Assoumou Okomo
    Citation: BMC Immunology 2020 21:52
    Content type: Research article Published on:

  49. Chronic immune activation and hyperglycaemia are a hallmark of type 2 diabetes mellitus (T2D) while natural killer (NK) cells are involved in the pathogenesis of T2D. Dysregulated NK cell responses are associa...

    Authors: Vuyolwethu Mxinwa, Phiwayinkosi V. Dludla, Tawanda M. Nyambuya, Kabelo Mokgalaboni, Sithandiwe E. Mazibuko-Mbeje and Bongani B. Nkambule
    Citation: BMC Immunology 2020 21:51
    Content type: Research article Published on:

  50. The use of inbred mice housed under standardized environmental conditions has been critical in identifying immuno-pathological mechanisms in different infectious and inflammatory diseases as well as revealing ...

    Authors: Josue Enriquez, Brianyell Mc Daniel Mims, Scott Trasti, Kathryn L. Furr and Matthew B. Grisham
    Citation: BMC Immunology 2020 21:50
    Content type: Review Published on:

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BMC Immunology

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