Skip to main content

Articles

1173 result(s) for 'immunology' within BMC Immunology

Page 23 of 24

  1. The saprophytic fungus Aspergillus fumigatus reproduces by generation of conidia, which are spread by airflow throughout nature. Since humans are inhaling certain amounts of spores every day, the (innate) immune ...

    Authors: Lothar Marischen, Anne Englert, Anna-Lena Schmitt, Hermann Einsele and Juergen Loeffler
    Citation: BMC Immunology 2018 19:39
    Content type: Research article Published on:

  3. Both antibody secreting cells (ASCs) and memory B cells are essential for the maintenance of humoral immunity. To date, limit studies have focused on the two populations in Kawasaki disease (KD). To address th...

    Authors: Meng Xu, Yanfang Jiang, Jinghua Wang, Jinxiang Liu, Congcong Liu, Deying Liu and Sirui Yang
    Citation: BMC Immunology 2019 20:16
    Content type: Research article Published on:

  4. Comprehensive understanding of cellular immune subsets involved in regulation of tumor progression is central to the development of cancer immunotherapies. Single cell immunophenotyping has historically been a...

    Authors: Elma Kadić, Raymond J. Moniz, Ying Huo, An Chi and Ilona Kariv
    Citation: BMC Immunology 2017 18:6
    Content type: Research article Published on:

  5. Galectin-3 is known to be a lectin that plays an important role in inflammatory processes, acting as pro-inflammatory mediator in activation and migration of neutrophils and macrophages, as well as in the phag...

    Authors: Camila Brand, Thayse Pinheiro da Costa, Emerson Soares Bernardes, Camila Maria Longo Machado, Leonardo Rodrigues Andrade, Roger Chammas, Felipe Leite de Oliveira and Márcia Cury El-Cheikh
    Citation: BMC Immunology 2015 16:68
    Content type: Research article Published on:

  6. Pepsin-trypsin resistant gliadin (PT-gliadin) promotes intestinal tissue inflammation and increases paracellular permeability of immunogenic gliadin peptides into the lamina propria. This leads to the complica...

    Authors: Naiyana Gujral, Ju Won Suh and Hoon H. Sunwoo
    Citation: BMC Immunology 2015 16:41
    Content type: Research article Published on:

  7. To initiate mucosal immune responses, antigens in the intestinal lumen must be transported into gut-associated lymphoid tissue through M cells. Recently, it has been increasingly recognized that receptor activ...

    Authors: Jeong-In Kim, Tae-Eun Park, Sushila Maharjan, Hui-Shan Li, Ho-Bin Lee, In-Seon Kim, Dachuan Piao, Jun-Yeong Lee, Chong-Su Cho, Jin-Duck Bok, Zhong-Shan Hong, Sang-Kee Kang and Yun-Jaie Choi
    Citation: BMC Immunology 2015 16:71
    Content type: Research article Published on:

  8. We have previously reported that interleukin-10 (IL-10) deficient dendritic cells (DCs) are potent antigen presenting cells that induced elevated protective immunity against Chlamydia. To further investigate the ...

    Authors: Khamia Ryans, Yusuf Omosun, Danielle N. McKeithen, Tankya Simoneaux, Camilla C. Mills, Nathan Bowen, Francis O. Eko, Carolyn M. Black, Joseph U. Igietseme and Qing He
    Citation: BMC Immunology 2017 18:27
    Content type: Research article Published on:

  9. Serglycin proteoglycans are essential for maturation of secretory granules and for the correct granular storage of cationic proteases in hematopoietic cells, e.g. mast cells. However, little is known about the...

    Authors: Ananya Roy, Osama Sawesi, Ulrika Pettersson, Anders Dagälv, Lena Kjellén, Anna Lundén and Magnus Åbrink
    Citation: BMC Immunology 2016 17:15
    Content type: Research article Published on:

  11. T cell activation induces ER stress and upregulates Inositol Requiring Enzyme 1 alpha (IRE1α), an activator of the unfolded protein response (UPR) pathway. Inhibition of IRE1α RNase activity in activated CD4+ spl...

    Authors: Cody Poe, Cheyanne Youngblood, Karissa Hodge and Kyeorda Kemp
    Citation: BMC Immunology 2019 20:3
    Content type: Research article Published on:

  12. Multiple sclerosis (MS) is an autoimmune disease in which dysregulated immune cells attack myelin in the central nervous system (CNS), leading to irreversible neuronal degeneration. Our previous studies have d...

    Authors: Enyu Rao, Puja Singh, Yan Li, Yuwen Zhang, Young-In Chi, Jill Suttles and Bing Li
    Citation: BMC Immunology 2015 16:28
    Content type: Research article Published on:

  13. IMGT®, the international ImMunoGeneTics information system® (http://​www.​imgt.​org), was created in 1989 in Montpellier, France (CNRS and Montpellier Uni...

    Authors: Véronique Giudicelli, Patrice Duroux, Sofia Kossida and Marie-Paule Lefranc
    Citation: BMC Immunology 2017 18:35
    Content type: Methodology article Published on:

  14. Ulcerative colitis, an inflammatory bowel disease, is associated with the massive infiltration of neutrophils. Although the initial infiltration of neutrophils is beneficial for killing bacteria, it is presume...

    Authors: Sumika Tokieda, Marie Komori, Toshifumi Ishiguro, Yoichiro Iwakura, Kazuhiko Takahara and Kayo Inaba
    Citation: BMC Immunology 2015 16:64
    Content type: Research article Published on:

  15. Melioidosis is endemic in Southeast Asia and Northern Australia and is caused by the Gram-negative, facultative intracellular pathogen Burkholderia pseudomallei. Diagnosis of melioidosis is often difficult becaus...

    Authors: Kei Amemiya, Jennifer L. Dankmeyer, Jeremy J. Bearss, Xiankun Zeng, Spencer W. Stonier, Carl Soffler, Christopher K. Cote, Susan L. Welkos, David P. Fetterer, Taylor B. Chance, Sylvia R. Trevino, Patricia L. Worsham and David M. Waag
    Citation: BMC Immunology 2020 21:5
    Content type: Research article Published on:

  16. IFNγ-producing CD4+CD25+Foxp3+CD127- Treg represent the first line of Treg during an immune response. In the present study we determined whether IFNγ+ Treg in-vivo and in-vitro are Helios-positive representing...

    Authors: Volker Daniel, Karina Trojan, Martina Adamek and Gerhard Opelz
    Citation: BMC Immunology 2015 16:45
    Content type: Research article Published on:

  18. Adoptive transfer of genetically engineered autologous T-cells is becoming a successful therapy for cancer. The avidity of the engineered T-cells is of crucial importance for therapy success. We have in the pa...

    Authors: Victoria Hillerdal, Vanessa F. Boura, Hanna Björkelund, Karl Andersson and Magnus Essand
    Citation: BMC Immunology 2016 17:23
    Content type: Research article Published on:

  19. Homeostatic B Cell-Attracting chemokine 1 (BCA-1) otherwise known as CXCL13 is constitutively expressed in secondary lymphoid organs by follicular dendritic cells (FDC) and macrophages. It is the only known li...

    Authors: Ekaterina Klimatcheva, Tracy Pandina, Christine Reilly, Sebold Torno, Holm Bussler, Maria Scrivens, Alan Jonason, Crystal Mallow, Michael Doherty, Mark Paris, Ernest S Smith and Maurice Zauderer
    Citation: BMC Immunology 2015 16:6
    Content type: Research article Published on:

  20. The use of immunodeficient mice transplanted with human hematopoietic stem cells is an accepted approach to study human-specific infectious diseases such as HIV-1 and to investigate multiple aspects of human i...

    Authors: Raghubendra Singh Dagur, Amanda Branch-Woods, Saumi Mathews, Poonam S. Joshi, Rolen M. Quadros, Donald W. Harms, Yan Cheng, Shana M. Miles, Samuel J. Pirruccello, Channabasavaiah B. Gurumurthy, Santhi Gorantla and Larisa Y. Poluektova
    Citation: BMC Immunology 2019 20:2
    Content type: Research article Published on:

  21. Down syndrome (DS) is the most common syndromic immunodeficiency with an increased risk of infection, mortality from sepsis, and autoinflammation. Innate immune function is altered in DS and therefore we exami...

    Authors: Dean Huggard, Fiona McGrane, Niamh Lagan, Edna Roche, Joanne Balfe, Timothy Ronan Leahy, Orla Franklin, Ana Moreno, Ashanty M. Melo, Derek G. Doherty and Eleanor J. Molloy
    Citation: BMC Immunology 2018 19:31
    Content type: Research article Published on:

  22. Phenotype of chronic rhinosinusitis (CRS) may be an important determining factor of the efficacy of anti-inflammatory treatments. Although both glucocorticoids and macrolide antibiotics have been recommended f...

    Authors: Ming Zeng, Zhi-Yong Li, Jin Ma, Ping-Ping Cao, Heng Wang, Yong-Hua Cui and Zheng Liu
    Citation: BMC Immunology 2015 16:37
    Content type: Research article Published on:

  23. Macrophages are tissue resident immune cells important for host defence and homeostasis. During diabetes, macrophages and other innate immune cells are known to have a pro-inflammatory phenotype, which is beli...

    Authors: Sofia Pavlou, Jaime Lindsay, Rebecca Ingram, Heping Xu and Mei Chen
    Citation: BMC Immunology 2018 19:24
    Content type: Research article Published on:

  24. Type 1 diabetes mellitus (T1D) is a chronic autoimmune disease caused by the selective destruction of pancreatic β cells, followed by hyperglycemia, oxidative stress and the subsequent extensive impairment of ...

    Authors: Ahmad A. Al Ghamdi, Gamal Badr, Wael N. Hozzein, Ahmed Allam, Noori S. Al-Waili, Mohammed A. Al-Wadaan and Olivier Garraud
    Citation: BMC Immunology 2015 16:54
    Content type: Research article Published on:

  25. We previously reported that JAK–STAT-pathway mediated regulation of IFN-regulatory factor genes could play an important role in SLE pathogenesis. Here, we evaluated the efficacy of the JAK inhibitor tofacitini...

    Authors: Keigo Ikeda, Kunihiro Hayakawa, Maki Fujishiro, Mikiko Kawasaki, Takuya Hirai, Hiroshi Tsushima, Tomoko Miyashita, Satoshi Suzuki, Shinji Morimoto, Naoto Tamura, Kenji Takamori, Hideoki Ogawa and Iwao Sekigawa
    Citation: BMC Immunology 2017 18:41
    Content type: Research article Published on:

  26. Despite effective antiretroviral therapy (ART), HIV-infected patients exhibit systemic inflammation, early onset of age-related diseases, and features of immunosenescence. The role of inflammation in the devel...

    Authors: Juliette Tavenier, Anne Langkilde, Thomas Huneck Haupt, Jens Henrik Henriksen, Frank Krieger Jensen, Janne Petersen and Ove Andersen
    Citation: BMC Immunology 2015 16:72
    Content type: Research article Published on:

  27. Cancer therapeutic vaccine induced cytotoxic T cell (CTL) responses are pivotal for the killing of tumour cells. Blocking interleukin 10 (IL-10) signalling at the time of immunization increases vaccine induced...

    Authors: Guoying Ni, Zaowen Liao, Shu Chen, Tianfang Wang, Jianwei Yuan, Xuan Pan, Kate Mounsey, Shelley Cavezza, Xiaosong Liu and Ming Q. Wei
    Citation: BMC Immunology 2017 18:40
    Content type: Research article Published on:

  28. Autoimmune diseases result from aberrant immune attacks by the body itself. It is mysterious how autoantigens, a large cohort of seemingly unconnected molecules expressed in different parts of the body, can in...

    Authors: Wei Zhang, Jung-hyun Rho, Michael H. Roehrl and Julia Y. Wang
    Citation: BMC Immunology 2019 20:21
    Content type: Research article Published on:

  29. Besides their prominent role in the elimination of infected or malignantly transformed cells, natural killer (NK) cells serve as modulators of adaptive immune responses. Enhancing bidirectional crosstalk betwe...

    Authors: Tammy Oth, Thomas H. P. M. Habets, Wilfred T. V. Germeraad, Marijke I. Zonneveld, Gerard M. J. Bos and Joris Vanderlocht
    Citation: BMC Immunology 2018 19:8
    Content type: Research article Published on:

  30. Vaccination generating a robust memory population of CD8+ T cells may provide protection against cancer. However, immune therapies for cancer are influenced by the local tumour immune microenvironment. An infiltr...

    Authors: Andrew J. Highton, Adam Girardin, Georgia M. Bell, Sarah M. Hook and Roslyn A. Kemp
    Citation: BMC Immunology 2016 17:39
    Content type: Research article Published on:

  31. The chronic course of pulmonary sarcoidosis can lead to lung dysfunction due to fibrosis, in which the signalling pathways TGF-β/Smad and VEGF-A may play a key role.

    Authors: Wojciech J. Piotrowski, Justyna Kiszałkiewicz, Paweł Górski, Adam Antczak, Witold Górski, Dorota Pastuszak-Lewandoska, Monika Migdalska-Sęk, Daria Domańska-Senderowska, Ewa Nawrot, Karolina H. Czarnecka, Zofia Kurmanowska and Ewa Brzeziańska-Lasota
    Citation: BMC Immunology 2015 16:58
    Content type: Research article Published on:

  32. Yersinia pestis, the etiological pathogen of plague, is capable of repressing the immune response of white blood cells to evade phagocytosis. The V-antigen (LcrV) was found to be involved in this process by bindi...

    Authors: Tiandi Wei, Jing Gong, Guojing Qu, Mingyu Wang and Hai Xu
    Citation: BMC Immunology 2019 20:48
    Content type: Research article Published on:

  33. Activation of inflammasome contributes to the clearance of intracellular bacteria. C-terminus of E. coli EscI protein can activate NLRC4 (NLR family, CARD domain containing-4) inflammasome in macrophages. The pur...

    Authors: Maozhi Hu, Weixin Zhao, Wei Gao, Wenhua Li, Chuang Meng, Qiuxiang Yan, Yuyang Wang, Xiaohui Zhou, Shizhong Geng, Zhiming Pan, Guiyou Cui and Xinan Jiao
    Citation: BMC Immunology 2017 18:21
    Content type: Research article Published on:

  34. The purpose of this study was to characterize specific cytotoxic T-cell (CTL) responses in men who have sex with men (MSM) subjects infected with the human immunodeficiency virus type 1 (HIV-1) CRF01_AE subtyp...

    Authors: Fanming Jiang, Xiaoxu Han, Hui Zhang, Bin Zhao, Minghui An, Junjie Xu, Zhenxing Chu, Tao Dong and Hong Shang
    Citation: BMC Immunology 2016 17:28
    Content type: Research article Published on:

  35. Immunoglobulin A nephropathy (IgAN), membranous nephropathy (MN) and minimal-change disease (MCD) are three common types of glomerulonephritis in China. Pathological diagnosis based on renal biopsy is the crit...

    Authors: Jin Dong, Tianhao Peng, Jing Gao, Xingwang Jia, Guangtao Yan and Yong Wang
    Citation: BMC Immunology 2018 19:18
    Content type: Research article Published on:

  36. Hyperactive secretion and pathogenic effects of interleukin (IL)-17 and IgA have been detected in different arthropathies. Recent evidence has revealed that TH17 cytokines regulate mucosal IgA secretion. However,...

    Authors: Ricardo Javier Eliçabe, Juan Eduardo Silva, Mabel Noemí Dave, María Gabriela Lacoste, Héctor Tamashiro, Rodrigo Blas, Alicia Munarriz, Gabriel Adrián Rabinovich and María Silvia Di Genaro
    Citation: BMC Immunology 2017 18:8
    Content type: Research article Published on:

  37. The need for rapid and accurate comparison of panels of adjuvanted vaccine formulations and subsequent rational down selection, presents several challenges for modern vaccine development. Here we describe a me...

    Authors: Sumera Y. Younis, Christophe Barnier-Quer, Simon Heuking, Vinod Sommandas, Livia Brunner, Nicole vd.Werff, Patrice Dubois, Martin Friede, Clemens Kocken, Nicolas Collin and Ed Remarque
    Citation: BMC Immunology 2018 19:6
    Content type: Research article Published on:

  39. The aim of the current study was to investigate the long non-coding RNA (lncRNA) expression profiles in psoriatic arthritis (PSA) patients by RNA sequencing, and to further explore potential biomarkers that we...

    Authors: Tao Yue, Mei Ji, Huanru Qu, Mengru Guo, Fengmin Bai, Zhanming Zhang, Weifeng Wang, Xuming Gong and Zhenghua Zhang
    Citation: BMC Immunology 2019 20:28
    Content type: Research article Published on:

  40. All-trans retinoid acid (ATRA) has been proven to skew Regulatory T cell-T helper 17 cell (Treg-Th17) balance toward Treg in vitro, favoring graft acceptance. However, its in vivo effect after solid organ transpl...

    Authors: Xin Wang, Wentao Wang, Jianjiang Xu, Suqian Wu and Qihua Le
    Citation: BMC Immunology 2015 16:17
    Content type: Research article Published on:

  41. Humanized mice (hu mice) are based on the transplantation of hematopoietic stem and progenitor cells into immunodeficient mice and have become important pre-clinical models for biomedical research. However, da...

    Authors: Annette Audigé, Mary-Aude Rochat, Duo Li, Sandra Ivic, Audrey Fahrny, Christina K. S. Muller, Gustavo Gers-Huber, Renier Myburgh, Simon Bredl, Erika Schlaepfer, Alexandra U. Scherrer, Stefan P. Kuster and Roberto F. Speck
    Citation: BMC Immunology 2017 18:28
    Content type: Research article Published on:

  42. In this work, we develop a theoretical model of an auto immune response. This is based on modifications of standard second messenger trigger models using both signalling pathways and diffusion and a macro leve...

    Authors: James K. Peterson, Alison M. Kesson and Nicholas J. C. King
    Citation: BMC Immunology 2017 18(Suppl 1):24
    Content type: Research Published on:

    This article is part of a Supplement: Volume 18 Supplement 1

  43. The role of pathogen specific cellular immune responses against the eliciting pathogen in development of post-infectious chronic fatigue syndrome (PI-CFS) is not known and such studies are difficult to perform...

    Authors: Kurt Hanevik, Einar Kristoffersen, Kristine Mørch, Kristin Paulsen Rye, Steinar Sørnes, Staffan Svärd, Øystein Bruserud and Nina Langeland
    Citation: BMC Immunology 2017 18:5
    Content type: Research article Published on:

  44. HIV-infected individuals with latent TB infection are at increased risk of developing active TB. HAART greatly reduces the incidence rate of TB in HIV-infected patients and reconstitutes Mycobacterium tuberculosi...

    Authors: Girmay Desalegn, Aster Tsegaye, Dawit Gebreegziabiher, Abraham Aseffa and Rawleigh Howe
    Citation: BMC Immunology 2019 20:35
    Content type: Research article Published on:

  45. Streptococcus pneumoniae, a major causative bacterial pathogen of community-acquired pneumonia, possesses a thick polysaccharide capsule. Host defense against this bacterium is mediate...

    Authors: Yukiko Akahori, Tomomitsu Miyasaka, Masahiko Toyama, Ikumi Matsumoto, Anna Miyahara, Tong Zong, Keiko Ishii, Yuki Kinjo, Yoshitsugu Miyazaki, Shinobu Saijo, Yoichiro Iwakura and Kazuyoshi Kawakami
    Citation: BMC Immunology 2016 17:1
    Content type: Research article Published on:

  46. CD1d is a widely expressed lipid antigen presenting molecule required for CD1d-restricted invariant natural killer T (iNKT) cell development. Elevated CD1d expression is detected in CD5+ IL10-producing B cells, c...

    Authors: Victoria L. Palmer, Vincent K. Nganga, Mary E. Rothermund, Greg A. Perry and Patrick C. Swanson
    Citation: BMC Immunology 2015 16:66
    Content type: Research article Published on:

  47. T-helper cell type 1 (Th1) polarization in chronic immune thrombocytopenia (cITP) has been reported at the protein and mRNA levels. We evaluated the impact of Th1/Th2 cytokine and cytokine receptor functional ...

    Authors: Noriyuki Takahashi, Takayuki Saitoh, Nanami Gotoh, Yasuhiro Nitta, Lobna Alkebsi, Tetsuhiro Kasamatsu, Yusuke Minato, Akihiko Yokohama, Norifumi Tsukamoto, Hiroshi Handa and Hirokazu Murakami
    Citation: BMC Immunology 2017 18:26
    Content type: Research article Published on:

  48. Invariant Natural Killer T (iNKT) cells have been implicated in lung inflammation in humans and also shown to be a key cell type in inducing allergic lung inflammation in mouse models. iNKT cells differentiate...

    Authors: Rosa Berga-Bolaños, Archna Sharma, Farrah C. Steinke, Kalyani Pyaram, Yeung-Hyen Kim, Dil A. Sultana, Jessie X. Fang, Cheong-Hee Chang, Hai-Hui Xue, Nicola M. Heller and Jyoti Misra Sen
    Citation: BMC Immunology 2015 16:62
    Content type: Research article Published on:

  49. Cryopreservation of peripheral blood mononuclear cells (PBMCs) is a common and essential practice in conducting research. There are different reports in the literature as to whether cryopreserved PBMCs need to...

    Authors: Jun Yang, Norma Diaz, Joseph Adelsberger, Xueyuan Zhou, Randy Stevens, Adam Rupert, Julia A. Metcalf, Mike Baseler, Christine Barbon, Tomozumi Imamichi, Richard Lempicki and Louis M. Cosentino
    Citation: BMC Immunology 2016 17:6
    Content type: Research article Published on:

  50. Recent studies indicate a central role for the IL-23/IL-17 axis in the pathogenesis of lupus nephritis (LN) but the importance in the context of treatment outcome is unknown. We studied various cytokines, incl...

    Authors: Agneta Zickert, Petra Amoudruz, Yvonne Sundström, Johan Rönnelid, Vivianne Malmström and Iva Gunnarsson
    Citation: BMC Immunology 2015 16:7
    Content type: Research article Published on:

Featured videos

View featured videos from across the BMC-series journals

Submit manuscript

Annual Journal Metrics

  • 2022 Citation Impact
    3.0 - 2-year Impact Factor
    3.6 - 5-year Impact Factor
    0.808 - SNIP (Source Normalized Impact per Paper)
    0.783 - SJR (SCImago Journal Rank)

    2023 Speed
    26 days submission to first editorial decision for all manuscripts (Median)
    188 days submission to accept (Median)

    2023 Usage 
    671,800 downloads
    176 Altmetric mentions

Follow

Sign up for article alerts and news from this journal

BMC Immunology

ISSN: 1471-2172

Contact us