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1171 result(s) for 'immunology' within BMC Immunology

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  1. Human peripheral blood mononuclear cells (PBMCs) originate from hematopoietic stem cells in the bone marrow, which mainly includes lymphocytes (T cells, B cells, and natural killer cells) and monocytes. Cryopr...

    Authors: Bo Li, Chunmei Yang, Gui Jia, Yansheng Liu, Na Wang, Fangfang Yang, Rui Su, Yulong Shang and Ying Han
    Citation: BMC Immunology 2022 23:30
    Content type: Research Published on:

  2. Differential polarization of macrophage into M1 and M2 mediates atherosclerotic plaque clearance through efferocytosis. Higher expression of Mer proto-oncogene tyrosine kinase (MerTK) on M2 macrophage helps in...

    Authors: Fatin Najiah Mohd Idrus, Nurul Shuhadah Ahmad, Chee Hock Hoe, Maryam Azlan, Farisha Alia Norfuad, Zurkurnai Yusof, Wan Yus Haniff Wan Isa, Akbar Ali Mohamed Ali and Get Bee Yvonne-Tee
    Citation: BMC Immunology 2021 22:21
    Content type: Research article Published on:

  3. Primary Sjogren’s Syndrome (pSS) is a lymphoproliferative disease with autoimmune characteristics, which is characterized by lymphocyte infiltration of exocrine glands and involvement and dysfunction of extrag...

    Authors: Liyun Cheng, Lu Liu, Ronghui Su, Huanhuan Yan, Xiaoyu Zi, Chong Gao, Xiaofeng Li and Caihong Wang
    Citation: BMC Immunology 2023 24:17
    Content type: Research Published on:

  4. The statistical analysis of immunological data may be complicated because precise quantitative levels cannot always be determined. Values below a given detection limit may not be observed (nondetects), and data w...

    Authors: Hae-Won Uh, Franca C Hartgers, Maria Yazdanbakhsh and Jeanine J Houwing-Duistermaat
    Citation: BMC Immunology 2008 9:59
    Content type: Methodology article Published on:

  5. The presence of the human leukocyte antigen HLA-B*57:01 is associated with the development of a hypersensitivity reaction to abacavir (ABC). Limited data exist on HLA-B*57:01 prevalence in individuals with HIV...

    Authors: Malewe Kolou, Armel Poda, Zelica Diallo, Esther Konou, Tatiana Dokpomiwa, Jacques Zoungrana, Mounerou Salou, Lionèle Mba-Tchounga, André Bigot, Abdoul-Salam Ouedraogo, Marielle Bouyout-Akoutet, Didier K. Ekouevi and Serge P. Eholie
    Citation: BMC Immunology 2021 22:48
    Content type: Research Published on:

  6. Vaccine literature indexing is poorly performed in PubMed due to limited hierarchy of Medical Subject Headings (MeSH) annotation in the vaccine field. Vaccine Ontology (VO) is a community-based biomedical onto...

    Authors: Junguk Hur, Zuoshuang Xiang, Eva L Feldman and Yongqun He
    Citation: BMC Immunology 2011 12:49
    Content type: Research article Published on:

  7. Mammals are essentially born germ-free but the epithelial surfaces are promptly colonized by astounding numbers of bacteria soon after birth. The most extensive microbial community is harbored by the distal in...

    Authors: Tomas Hrncir, Renata Stepankova, Hana Kozakova, Tomas Hudcovic and Helena Tlaskalova-Hogenova
    Citation: BMC Immunology 2008 9:65
    Content type: Research article Published on:

  8. Identifying immunogens which can elicit effective T cell responses against human immunodeficiency virus type 1 (HIV-1) is important for developing a T-cell based vaccine. It has been reported that human leukoc...

    Authors: Hui Zhang, Chuan He, Fanming Jiang, Shuang Cao, Bin Zhao, Haibo Ding, Tao Dong, Xiaoxu Han and Hong Shang
    Citation: BMC Immunology 2022 23:15
    Content type: Research Published on:

  10. In this work we present evidence that the p53 tumor suppressor protein and NF-κB transcription factors could be related through common descent from a family of ancestral transcription factors regulating cellul...

    Authors: David H Dreyfus, Masayuki Nagasawa, Erwin W Gelfand and Lucy Y Ghoda
    Citation: BMC Immunology 2005 6:12
    Content type: Research article Published on:

  11. Cryopreservation of peripheral blood mononuclear cells has been used to preserve and standardize immunologic measurements for multicenter studies, however, effects of cryopreservation on cytokine responses are...

    Authors: Wayne G Shreffler, Cynthia M Visness, Melissa Burger, William W Cruikshank, Howard M Lederman, Maite de la Morena, Kristine Grindle, Agustin Calatroni, Hugh A Sampson and James E Gern
    Citation: BMC Immunology 2006 7:29
    Content type: Methodology article Published on:

  12. Larvae of several common species of parasitic nematodes obligately migrate through, and often damage, host lungs. The larvae induce strong pulmonary Type 2 immune responses, including T-helper (Th)2 cells as w...

    Authors: Marieke A Hoeve, Katie J Mylonas, Karen J Fairlie-Clarke, Simmi M Mahajan, Judith E Allen and Andrea L Graham
    Citation: BMC Immunology 2009 10:60
    Content type: Research article Published on:

  13. Previous studies have indicated that the programmed death molecule 1 (PD-1) signaling pathway may play a key role in rheumatoid arthritis (RA). However, the pathogenesis of rheumatoid arthritis-related interst...

    Authors: Li Xu, Lichun Jiang, Liuyan Nie, Songzhao Zhang, Lei Liu, Yan Du and Jing Xue
    Citation: BMC Immunology 2021 22:69
    Content type: Research Published on:

  14. Respiratory burst function resulting in the release of reactive oxygen species such as superoxide anion (O2-) from neutrophils is one of the key mechanisms of the innate immune system, and maladaptive control of ...

    Authors: John-Paul Tung, John F Fraser, Peter Wood and Yoke Lin Fung
    Citation: BMC Immunology 2009 10:25
    Content type: Research article Published on:

  15. Patients with Sjögren’s syndrome, like other patients with autoimmune disorders, display dysregulation in the function of their immune system. Fas and Fas Ligand (FasL) are among the dysregulated proteins.

    Authors: Irena Lindrova, Martina Kolackova, Tereza Svadlakova, Radka Vankova, Marcela Chmelarova, Michaela Rosecka, Eva Jozifkova, Martin Sembera, Jan Krejsek and Radovan Slezak
    Citation: BMC Immunology 2023 24:12
    Content type: Research article Published on:

  16. Symptomatic Primary Humoral Immunodeficiency Diseases (PHID) constitute a highly heterogeneous group of diseases characterized by a shared hypogammaglobulinemia, resulting in increased risk of recurrent or sev...

    Authors: Marie-Quitterie Picat, Rodolphe Thiébaut, François Lifermann, Xavier Delbrel, Daniel Adoue, Linda Wittkop, Anne-Laure Fauchais, Patrick Rispal, Jean-François Moreau and Jean-François Viallard
    Citation: BMC Immunology 2014 15:13
    Content type: Research article Published on:

  17. There is strong evidence implicating eosinophils in host defence against parasites as well as allergic disease pathologies. However, a lack of reagents such as monoclonal antibodies (mAbs) specific for eosinop...

    Authors: Georgina M Sansome, Anna R Young, Els NT Meeusen and Robert J Bischof
    Citation: BMC Immunology 2007 8:23
    Content type: Research article Published on:

  18. The differentiation of naive T and B cells into memory lymphocytes is essential for immunity to pathogens. Therapeutic manipulation of this cellular differentiation program could improve vaccine efficacy and t...

    Authors: W Nicholas Haining, Jill Angelosanto, Kathleen Brosnahan, Kenneth Ross, Cynthia Hahn, Kate Russell, Linda Drury, Stephanie Norton, Lee Nadler and Kimberly Stegmaier
    Citation: BMC Immunology 2008 9:44
    Content type: Methodology article Published on:

  19. Common variable immunodeficiency (CVID) is an inborn errors of immunity, that leads to recurrent chronic infections and autoimmune/ inflammatory diseases and neoplasms. It is considered that these condition is...

    Authors: Itana Gomes Alves Andrade, Fabíola Isabel Suano de Souza, Fernando Luiz Affonso Fonseca, Carolina Sanchez Aranda and Roseli Oselka Saccardo Sarni
    Citation: BMC Immunology 2021 22:31
    Content type: Research Published on:

  20. The mechanisms of immune response are structured within a highly complex regulatory system. Genetic associations with variation in the immune response to rubella vaccine have typically been assessed one locus ...

    Authors: V Shane Pankratz, Robert A Vierkant, Megan M O'Byrne, Inna G Ovsyannikova and Gregory A Poland
    Citation: BMC Immunology 2010 11:48
    Content type: Research article Published on:

  21. Natural killer (NK) cells in the cow have been elusive due to the lack of specific NK cell markers, and various criteria including a CD3-/CD2+ phenotype have been used to identify such cells. The recent character...

    Authors: Preben Boysen, Ingrid Olsen, Ingvild Berg, Siri Kulberg, Grethe M Johansen and Anne K Storset
    Citation: BMC Immunology 2006 7:10
    Content type: Research article Published on:

  22. The number of subjects that can be recruited in immunological studies and the number of immunological parameters that can be measured has increased rapidly over the past decade and is likely to continue to exp...

    Authors: Bernd Genser, Philip J Cooper, Maria Yazdanbakhsh, Mauricio L Barreto and Laura C Rodrigues
    Citation: BMC Immunology 2007 8:27
    Content type: Commentary Published on:

  23. Primary immunodeficiency diseases (PIDs) comprise a heterogeneous group of disorders mainly characterized by increased susceptibility to infections. The aims of this study were to estimate the occurrence rate ...

    Authors: Nicholas Brodszki, Göran Jönsson, Lillemor Skattum and Lennart Truedsson
    Citation: BMC Immunology 2014 15:31
    Content type: Research article Published on:

  24. Fishing communities surrounding Lake Victoria in Uganda have HIV prevalence of 28% and incidence rates of 5 per 100 person years. More than 50% of the local fishermen are infected with Schistosoma mansoni (S. man...

    Authors: Andrew Ekii Obuku, Jacqueline Kyosiimire Lugemwa, Andrew Abaasa, Moses Joloba, Song Ding, Justin Pollara, Guido Ferrari, Alexandre Harari, Giuseppe Pantaleo and Pontiano Kaleebu
    Citation: BMC Immunology 2023 24:25
    Content type: Research Published on:

  25. Although plasmid DNA encoding an antigen from pathogens or tumor cells has been widely studied as vaccine, the use of plasmid vector (without insert) as therapeutic agent requires further investigation.

    Authors: Thiago Malardo, Marcelo E Batalhão, Ademilson Panunto-Castelo, Luciana P Almeida, Everton Padilha, Isabela C Fontoura, Célio L Silva, Evelin C Carnio and Arlete AM Coelho-Castelo
    Citation: BMC Immunology 2012 13:59
    Content type: Research article Published on:

  26. Iloprost has been suggested to possess anti-inflammatory and immunomodulating actions and it is widely use as a vasodilatator in systemic sclerosis (SSc). In this study we evaluate the effect of iloprost on im...

    Authors: Patrizia D'Amelio, Maria A Cristofaro, Lucia D'Amico, Luciana Veneziano, Ilaria Roato, Francesca Sassi, Giuseppina Bisignano, Marta Saracco, Raffaele Pellerito, Salvatore Patanè, Riccardo Ferracini, Gian P Pescarmona and Giovanni C Isaia
    Citation: BMC Immunology 2010 11:62
    Content type: Research article Published on:

  27. Antinuclear antibodies are useful diagnostic tools in several autoimmune diseases. However, the routine detection of nuclear envelope autoantibodies using immunofluorescence (IF) is not always easy to perform ...

    Authors: Vagia Tsiakalou, Elena Tsangaridou, Hara Polioudaki, Artemissia-Phoebe Nifli, Meri Koulentaki, Tonia Akoumianaki, Elias Kouroumalis, Elias Castanas and Panayiotis A Theodoropoulos
    Citation: BMC Immunology 2006 7:20
    Content type: Methodology article Published on:

  28. RelB, a member of the NF-κB family, plays a critical role in the development of T cells. However, the role of RelB in Foxp3+ regulatory T cells (Tregs) remains controversial.

    Authors: Shuping Zhou, Weiwei Wu, Zhaoxia Wang, Zhaopeng Wang, Qinghong Su, Xiaofan Li, Yong Yu, Weidong Zhang, Mingzhao Zhu and Wei Lin
    Citation: BMC Immunology 2020 21:37
    Content type: Research article Published on:

  29. Pregnancy-specific β1-glycoproteins are capable of regulating innate and adaptive immunity, exerting predominantly suppressive effects. In this regard, they are of interest in terms of their pharmacological po...

    Authors: Valeria P. Timganova, Svetlana A. Zamorina, Larisa S. Litvinova, Natalia M. Todosenko, Maria S. Bochkova, Pavel V. Khramtsov and Mikhail B. Rayev
    Citation: BMC Immunology 2020 21:56
    Content type: Research article Published on:

  30. Ehrlichia chaffeens is is a bacterial pathogen that causes fatal human monocytic ehrlichiosis (HME) that mimic toxic shock-like syndrome. Murine studies indicate that over activation of cellular immunity followed...

    Authors: Nahed Ismail, David H Walker, Purnima Ghose and Yi-Wei Tang
    Citation: BMC Immunology 2012 13:26
    Content type: Research article Published on:

  31. T cell lymphopenia was a significant characteristic of severe influenza infection and it was associated with the functional changes of T cells. It is necessary to clarify the T cells characteristics of kinetic...

    Authors: Shuai Liu, Zhisheng Huang, Ruyue Fan, Ju Jia, Xiaoyan Deng, Xiaohui Zou, Hui Li and Bin Cao
    Citation: BMC Immunology 2022 23:40
    Content type: Research Published on:

  32. Regulatory T cells (Tregs) are required for proper maintenance of immunological self-tolerance and immune homeostasis. Folate receptor 4 (FR4) is expressed at high levels in transforming growth factor-beta (TG...

    Authors: Yi Tian, Guoqiang Wu, Jun-Chao Xing, Jun Tang, Yi Zhang, Ze-Min Huang, Zheng-Cai Jia, Ren Zhao, Zhi-Qiang Tian, Shu-Feng Wang, Xiao-Ling Chen, Li Wang, Yu-Zhang Wu and Bing Ni
    Citation: BMC Immunology 2012 13:30
    Content type: Research article Published on:

  33. There is a global focus on illness diagnosis in smear-negative and latent tuberculosis infectious populations (SN-TB and LTBI). CD27 has been suggested to play a direct role in active TB. Little is known about...

    Authors: Feifan Xu, Haiyun Zhang, Xiaoyan Si, Junlin Chen, Yuhao Chen, Xiaopeng Cui and Yongwei Qin
    Citation: BMC Immunology 2021 22:41
    Content type: Research article Published on:

  34. Natural Killer (NK) cells are a crucial component of the host innate immune system with anti-viral and anti-cancer properties. However, the role of NK cells in West Nile virus (WNV) infection is controversial,...

    Authors: Mingjie Zhang, Sylvester Daniel, Yong Huang, Caren Chancey, Qingsheng Huang, Ying F Lei, Andriyan Grinev, Howard Mostowski, Maria Rios and Andrew Dayton
    Citation: BMC Immunology 2010 11:3
    Content type: Research article Published on:

  35. Deer mice (Peromyscus maniculatus) are the most common mammals in North America and are reservoirs for several zoonotic agents, including Sin Nombre virus (SNV), the principal etiologic agent of hantavirus cardio...

    Authors: Lauren Oko, Bethany Aduddell-Swope, Derall Willis, Robyn Hamor, Teresa A Coons, Brian Hjelle and Tony Schountz
    Citation: BMC Immunology 2006 7:18
    Content type: Methodology article Published on:

  36. The successful ex vivo expansion of T-cells in great numbers is the cornerstone of adoptive cell therapy. We aimed to achieve the most optimal T-cell expansion condition by comparing the expansion of T-cells a...

    Authors: Sasan Ghaffari, Monireh Torabi-Rahvar, Sajjad Aghayan, Zahra Jabbarpour, Kobra Moradzadeh, Azadeh Omidkhoda and Naser Ahmadbeigi
    Citation: BMC Immunology 2021 22:43
    Content type: Research Published on:

  39. Short dimeric or mulitmeric peptides derived from a highly conserved stretch of amino acids from gammaretroviral envelope proteins has been found to have immunosuppressive properties in vitro. Here we test the hy...

    Authors: Martin Tolstrup, Claus Johansen, Lars Toft, Finn S Pedersen, Anne Funding, Shervin Bahrami, Lars Iversen, Lars Østergaard and Mogens Duch
    Citation: BMC Immunology 2013 14:51
    Content type: Research article Published on:

  40. Transglutaminases (TGases) form a group of enzymes that have many different substrates and among the most well known are fibrin for Factor XIIIa and the clotting protein in crustaceans. We also found that TGas...

    Authors: Xionghui Lin, Kenneth Söderhäll and Irene Söderhäll
    Citation: BMC Immunology 2008 9:58
    Content type: Research article Published on:

  41. Deer mice (Peromyscus maniculatus) are among the most common mammals in North America and are important reservoirs of several human pathogens, including Sin Nombre hantavirus (SNV). SNV can establish a life-long ...

    Authors: Tiffany Richens, Aparna D~N Palmer, Joseph Prescott and Tony Schountz
    Citation: BMC Immunology 2008 9:62
    Content type: Research article Published on:

  42. Kawasaki disease is an autoimmune disease characterized by systemic vasculitis of unknown aetiology and most commonly occurs in children under 5 years old. Previous studies have found that the over-activation ...

    Authors: Qian Wu, Ruohang Weng, Yongbin Xu, Linlin Wang, Yanyan Huang and Jun Yang
    Citation: BMC Immunology 2021 22:17
    Content type: Research article Published on:

  43. Decoy receptor 3 (DcR3), a member of the tumor necrosis factor receptor (TNFR) superfamily, is associated with anti-tumor immunity suppression. It is highly expressed in many tumors, and its expression can be ...

    Authors: Donghai Yang, Xin Fan, Ping Yin, Qiang Wen, Feng Yan, Sibo Yuan, Bin Liu, Guohong Zhuang and Zhongchen Liu
    Citation: BMC Immunology 2012 13:28
    Content type: Research article Published on:

  44. Insulin dependent (i.e., "type 1") diabetes mellitus (T1DM) is considered to be a T cell mediated disease in which TH1 and Tc autoreactive cells attack the pancreatic islets. Among the beta-cell antigens implicat...

    Authors: Rosetta Pedotti, Maija Sanna, Mindy Tsai, Jason DeVoss, Lawrence Steinman, Hugh McDevitt and Stephen J Galli
    Citation: BMC Immunology 2003 4:2
    Content type: Research article Published on:

  45. Lymphedema is an intractable disease that can be caused by injury to lymphatic vessels, such as by surgical treatments for cancer. It can lead to impaired joint mobility in the extremities and reduced quality ...

    Authors: Toshihiko Nishioka, Kei-ichi Katayama, Shinji Kumegawa, Kyoichi Isono, Takashi Baba, Hiroshi Tsujimoto, Gen Yamada, Norimitsu Inoue and Shinichi Asamura
    Citation: BMC Immunology 2023 24:42
    Content type: Research Published on:

  46. The aqueous extract of a Brazilian palm-tree fruit - the babassu - (BAE) exerts a clear immunostimulative activity in vivo. In the present work, the possibility that BAE can promote Th1 immune responses in mice o...

    Authors: Rosane NM Guerra, Virgínia MG Silva, Luciana S Aragão-França, Pablo R Oliveira, Rodrigo Feitosa, Flavia RF Nascimento and Lain C Pontes-de-Carvalho
    Citation: BMC Immunology 2011 12:13
    Content type: Research article Published on:

  47. Thymic stromal lymphopoietin (TSLP) is an interleukin-7 (IL-7) like cytokine, which plays an important role in the regulation of immune responses to allergens. TSLP binds to a heterodimeric receptor complex co...

    Authors: Jun Zhong and Akhilesh Pandey
    Citation: BMC Immunology 2010 11:5
    Content type: Research article Published on:

  48. Fms-like tyrosine kinase-3 ligand (Flt3L) is a hemopoietic cytokine and dendritic cell (DC) growth factor that promotes the proliferation and differentiation of progenitor cells into DCs. We have previously fo...

    Authors: Julia K Bohannon, Weihua Cui and Tracy Toliver-Kinsky
    Citation: BMC Immunology 2009 10:47
    Content type: Research article Published on:

  49. To understand the evolutionary origins of our own immune system, we need to characterise the immune system of our distant relatives, the marsupials and monotremes. The recent sequencing of the genomes of two m...

    Authors: Emily SW Wong, Anthony T Papenfuss and Katherine Belov
    Citation: BMC Immunology 2011 12:48
    Content type: Database Published on:

  50. CTLA-4 was initially described as a membrane-bound molecule that inhibited lymphocyte activation by interacting with B7.1 and B7.2 molecules on antigen presenting cells. Alternative splicing of mRNA encoding t...

    Authors: Matt Tector, Bhupendra O Khatri, Karen Kozinski, Kate Dennert and Martin K Oaks
    Citation: BMC Immunology 2009 10:51
    Content type: Research article Published on:

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