Gene expression trees in lymphoid development

BMC Immunology

Table 1 List of LympMIR enriched in the clusters from MixDTrees on data sets TCell and BCell

Cluster ID	MicroRNA	Target Genes
TCell 3	miR-222	Elovl6, Nme1, Rcn1, Rps3
TCell 5	miR-15a¹, miR-181a², miR-221³,	2410015N17Rik⁴, Alad^1,4, Atpif1^1,5, *Aurkb², Cdc25a¹, Chek1*¹
	miR-24⁴, miR-26a⁵	*Cks1b^2,4, Cks2⁵, Eed², H2afx⁴, Kpnb1³, Mcm5³, Nasp^3,5, Pex7², Psmd12², Ranbp5², Rars¹, Tk1³, Trip13¹, Uchl5*⁵
TCell 10	miR-142-3p⁶, miR-150⁷	Gfi1⁶, Marcks⁶, Msh6⁶, Pp11r⁷, Psmc1^6,7
TCell 11	miR-146⁸, miR-16⁹, miR-181b¹⁰	Atp1b3¹⁰, Ipo4⁹, Klhdc2¹⁰, Mrpl30⁸, Orc5l⁸, Tuba4⁹
BCell 3	miR-181b¹, miR-181c², miR-26a³	Atpif1³, *Aurkb^1,2, Cbx1³, Cdc45l², Cks1b^1,2, Cks2³, Cox5a³, Hmgb2^1,2, Melk^1,2, Ttk^1,2, Uchl5*³
BCell 5	miR-15a⁴, miR-15b⁵, miR-221⁶,	*Cdca4^4,5, Chek1^4,5, Mcm4⁷, Nasp⁶, Nfyb⁶, Smc4l1*⁷
	miR-223⁷	Tuba2 ^4,5,7
BCell 6	miR-155⁸, miR-191⁹	*Ctps⁹, Ddx1⁸, Hint1⁹, Mcm2⁸, Phf17⁸, Prdx4⁹, SNrpd1*⁹
BCell 19	miR-142-3p¹⁴, miR-342¹⁵	2410002F23Rik¹⁴, H2-Eb1¹⁴, Ltb¹⁵, Tap2^14,15

We display the cluster and data set id, the list of microRNA and list of target genes, with p-values < 0.05 and at least four target genes per cluster. Genes involved in cell proliferation or DNA repair are depicted in bold. The indices indicates to which microRNA a gene is related, when there is more than one enriched microRNA in a cluster.

ISSN: 1471-2172