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Table 2 Summary of significant differences in parameters found between groups

From: Characterisation of cell functions and receptors in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME)

 

Significant Parameters

Group

Potential Result of Changes

NK cell

↓ CD56dimCD16 CD2+

M v S

Impaired ability to adhere to target cells [24].

↓ CD56dimCD16 CD18+CD2+

M v S

Reduced NK cells in an active state hence lessened NK cell activation and cytotoxic activity [24, 55].

↑ CD56dimCD16 CD18+CD11c

S v C

Decreased adhesive abilities or lower number of activated cells [55].

↓ CD56brightCD16dim NKp46

S v C, S v M

Reduced recognition and lysis of target cells [41].

↓ Total SLAM

S v M

Lessened ability of NK cells to undergo cytotoxic activity [40].

CD4+ T cell

↑ Total KIR2DL5

M v S

Inhibition of T cell functions [51].

↓ Naïve KLRG1

M v C, M v S

Enhanced T cell activation [46].

↑ Central Memory BTLA4

M v C

Greater inhibitory signalling and modulation of immune responses [52].

CD8+ T cell

↑ CD45RA Effector Memory

M v C

Heightened capacity for cytotoxic activities [43].

↓ Central Memory LFA-1

M v C

Lack of LFA-1 adhesion required for optimal cytotoxic activity [53].

↓ Total KLRG1

M v C

Enhanced T cell activation [46].

  1. ↓ represents significant reductions and ↑ represents significant increases in the group listed first in the ‘Group’ column compared with the group listed second in the ‘Group’ column. S Severe CFS/ME patients; M Moderate CFS/ME patients; C Controls