Maes M, Twisk FN, Kubera M, Ringel K. Evidence for inflammation and activation of cell-mediated immunity in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): increased interleukin-1, tumor necrosis factor-α, PMN-elastase, lysozyme and neopterin. J Affect Disord. 2012;136(3):933–9.
Article
CAS
PubMed
Google Scholar
Seide A, Arolt V, Hunstiger M, Rink L, Behnisch A, Kirchner H. Increased CD56 < sup > +</sup > natural killer cells and related cytokines in major depression. Clin Immunol Immunopathol. 1996;78(1):83–5.
Article
Google Scholar
Blanca IR, Bere EW, Young HA, Ortaldo JR. Human B cell activation by autologous NK cells is regulated by CD40-CD40 ligand interaction: role of memory B cells and CD5+ B cells. J Immunol. 2001;167(11):6132–9.
Article
CAS
PubMed
Google Scholar
Schepis D, Gunnarsson I, Eloranta ML, Lampa J, Jacobson SH, Kärre K, et al. Increased proportion of CD56bright natural killer cells in active and inactive systemic lupus erythematosus. Immunology. 2009;126(1):140–6.
Article
PubMed Central
CAS
PubMed
Google Scholar
Hardcastle S, Brenu E, Johnston S, Nguyen T, Huth T, Kaur M. Analysis of the relationship between immune dysfunction and symptom severity in patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME). J Clin Cell Immunol. 2014;5(190):2.
Google Scholar
Landay A, Lennette E, Jessop C, Levy J. Chronic fatigue syndrome: clinical condition associated with immune activation. Lancet. 1991;338(8769):707–12.
Article
CAS
PubMed
Google Scholar
Brenu, Hardcastle, Atkinson G, van Driel M, Kreijkamp-Kaspers S, Ashton K, et al.: Natural killer cells in patients with severe chronic fatigue syndrome. Autoimmunity Highlights 2013;4(3):1–12.
Brenu EW, Staines DR, Baskurt OK, Ashton KJ, Ramos SB, Christy RM, et al. Immune and hemorheological changes in chronic fatigue syndrome. J Transl Med. 2010;8(1):1.
Article
PubMed Central
PubMed
Google Scholar
Brenu EW, van Driel ML, Staines DR, Ashton KJ, Hardcastle SL, Keane J, et al. Longitudinal investigation of natural killer cells and cytokines in chronic fatigue syndrome/myalgic encephalomyelitis. J Transl Med. 2012;10:88.
Article
PubMed Central
CAS
PubMed
Google Scholar
Brenu EW, van Driel ML, Staines DR, Ashton KJ, Ramos SB, Keane J, et al. Immunological abnormalities as potential biomarkers in chronic fatigue syndrome/myalgic encephalomyelitis. J Transl Med. 2011;9:81.
Article
PubMed Central
CAS
PubMed
Google Scholar
Klimas NG, Salvato FR, Morgan R, Fletcher MA. Immunologic abnormalities in chronic fatigue syndrome. J Clin Microbiol. 1990;28(6):1403–10.
PubMed Central
CAS
PubMed
Google Scholar
Levine PH, Whiteside TL, Friberg D, Bryant J, Colclough G, Herberman RB. Dysfunction of natural killer activity in a family with chronic fatigue syndrome. Clin Immunol Immunopathol. 1998;88(1):96–104.
Article
CAS
PubMed
Google Scholar
Ojo-Amaize EA, Conley EJ, Peter JB. Decreased natural killer cell activity is associated with severity of chronic fatigue immune dysfunction syndrome. Clin Infect Dis. 1994;18(Supplement 1):S157–9.
Article
PubMed
Google Scholar
Patarca-Montero R, Antoni M, Fletcher MA, Klimas NG. Cytokine and other immunologic markers in chronic fatigue syndrome and their relation to neuropsychological factors. Appl Neuropsychol. 2001;8(1):51–64.
Article
CAS
PubMed
Google Scholar
Barker E, Fujimura SF, Fadem MB, Landay AL, Levy JA. Immunologic abnormalities associated with chronic fatigue syndrome. Clin Infect Dis. 1994;18(Supplement 1):S136–41.
Article
PubMed
Google Scholar
Brenu E, Johnston S, Hardcastle S, Huth T, Fuller K, Ramos S, et al. Immune abnormalities in patients meeting new diagnostic criteria for chronic fatigue syndrome/Myalgic Encephalomyelitis. J Mol Biomark Diagn. 2013;4(152.10):4172.
Google Scholar
Brenu EW, Huth TK, Hardcastle SL, Fuller K, Kaur M, Johnston S, et al. Role of adaptive and innate immune cells in chronic fatigue syndrome/myalgic encephalomyelitis. Int Immunol. 2013;26:dxt068.
Google Scholar
Brenu EW, van Driel M, Staines DR, Kreijkamp-Kaspers S, Hardcastle SL, Marshall-Gradisnik SM. The effects of influenza vaccination on immune function in patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis. International J Clinical Med. 2012;3:544.
Article
Google Scholar
Caligiuri M, Murray C, Buchwald D, Levine H, Cheney P, Peterson D, et al. Phenotypic and functional deficiency of natural killer cells in patients with chronic fatigue syndrome. J Immunol. 1987;139(10):3306–13.
CAS
PubMed
Google Scholar
Maher KJ, Klimas NG, Fletcher MA. Chronic fatigue syndrome is associated with diminished intracellular perforin. Clin Exp Immunol. 2005;142(3):505–11.
PubMed Central
CAS
PubMed
Google Scholar
Patarca R, Klimas NG, Garcia MN, Walters MJ, Dombroski D, Pons H, et al. Dysregulated expression of soluble immune mediator receptors in a subset of patients with chronic fatigue syndrome: cross-sectional categorization of patients by immune status. J Chronic Fatigue Syndrome. 1995;1(1):81–96.
Article
Google Scholar
Tirelli U, Marotta G, Improta S, Pinto A. Immunological abnormalities in patients with chronic fatigue syndrome. Scand J Immunol. 1994;40(6):601–8.
Article
CAS
PubMed
Google Scholar
Aoki T, Miyakoshi H, Usuda Y, Herberman RB. Low NK syndrome and its relationship to chronic fatigue syndrome. Clin Immunol Immunopathol. 1993;69(3):253–65.
Article
CAS
PubMed
Google Scholar
Huth T, Brenu E, Nguyen T, Hardcastle S, Johnston S. Characterization of natural killer cell phenotypes in chronic fatigue Syndrome/Myalgic Encephalomyelitis. J Clin Cell Immunol. 2014;5(223):2.
Google Scholar
Brenu EW, Ashton KJ, van Driel M, Staines DR, Peterson D, Atkinson GM, et al. Cytotoxic lymphocyte microRNAs as prospective biomarkers for chronic fatigue syndrome/myalgic encephalomyelitis. J Affect Disord. 2012;141(2):261–9.
Article
CAS
PubMed
Google Scholar
Saiki T, Kawai T, Morita K, Ohta M, Saito T, Rokutan K, et al. Identification of marker genes for differential diagnosis of chronic fatigue syndrome. Mol Med. 2008;14(9–10):599.
PubMed Central
CAS
PubMed
Google Scholar
Baraniuk JN, Adewuyi O, Merck SJ, Ali M, Ravindran MK, Timbol CR, et al. A Chronic Fatigue Syndrome (CFS) severity score based on case designation criteria. Am J Transl Res. 2013;5(1):53–68.
PubMed Central
PubMed
Google Scholar
Carruthers BM, van de Sande MI, De Meirleir KL, Klimas NG, Broderick G, Mitchell T, et al. Myalgic encephalomyelitis: international consensus criteria. J Intern Med. 2011;270(4):327–38.
Article
PubMed Central
CAS
PubMed
Google Scholar
Fukuda K, Straus SE, Hickie I, Sharpe MC, Dobbins JG, Komaroff A. The chronic fatigue syndrome: a comprehensive approach to its definition and study. Ann Intern Med. 1994;121(12):953–9.
Article
CAS
PubMed
Google Scholar
Zaturenskaya M, Jason LA, Torres-Harding S, Tryon WW. Subgrouping in chronic fatigue syndrome based on actigraphy and illness severity. Open Biology J. 2009;2:20–6.
Article
Google Scholar
Jason LA, Corradi K, Torres-Harding S, Taylor RR, King C. Chronic fatigue syndrome: the need for subtypes. Neuropsychol Rev. 2005;15(1):29–58.
Article
PubMed
Google Scholar
Wiborg JF, van der Werf S, Prins JB, Bleijenberg G. Being homebound with chronic fatigue syndrome: a multidimensional comparison with outpatients. Psychiatry Res. 2010;177(1):246–9.
Article
PubMed
Google Scholar
Lloyd AR, Wakefield D, Boughton C, Dwyer J. Immunological abnormalities in the chronic fatigue syndrome. Med J Aust. 1989;151(3):122.
CAS
PubMed
Google Scholar
Bansal A, Bradley A, Bishop K, Kiani-Alikhan S, Ford B. Chronic fatigue syndrome, the immune system and viral infection. Brain Behav Immun. 2012;26(1):24–31.
Article
CAS
PubMed
Google Scholar
Fluge Ø, Bruland O, Risa K, Storstein A, Kristoffersen EK, Sapkota D, et al. Benefit from B-lymphocyte depletion using the anti-CD20 antibody rituximab in chronic fatigue syndrome. A double-blind and placebo-controlled study. PLoS One. 2011;6(10):e26358.
Article
PubMed Central
CAS
PubMed
Google Scholar
Klimas NG, Broderick G, Fletcher MA. Biomarkers for chronic fatigue. Brain Behav Immun. 2012;26(8):1202–10.
Article
CAS
PubMed
Google Scholar
Sidorenko SP, Clark EA. The dual-function CD150 receptor subfamily: the viral attraction. Nat Immunol. 2003;4(1):19–24.
Article
CAS
PubMed
Google Scholar
Lanier LL. On guard—activating NK cell receptors. Nat Immunol. 2001;2(1):23–7.
Article
CAS
PubMed
Google Scholar
Wang N, Morra M, Wu C, Gullo C, Howie D, Coyle T, et al. CD150 is a member of a family of genes that encode glycoproteins on the surface of hematopoietic cells. Immunogenetics. 2001;53(5):382–94.
Article
CAS
PubMed
Google Scholar
Veillette A. NK cell regulation by SLAM family receptors and SAP‐related adapters. Immunol Rev. 2006;214(1):22–34.
Article
CAS
PubMed
Google Scholar
Biassoni R, Cantoni C, Pende D, Sivori S, Parolini S, Vitale M, et al. Human natural killer cell receptors and co‐receptors. Immunol Rev. 2001;181(1):203–14.
Article
CAS
PubMed
Google Scholar
Poli A, Michel T, Thérésine M, Andrès E, Hentges F, Zimmer J. CD56bright natural killer (NK) cells: an important NK cell subset. Immunology. 2009;126(4):458–65.
Article
PubMed Central
CAS
PubMed
Google Scholar
Anane LH, Edwards KM, Burns VE, Zanten JJ, Drayson MT, Bosch JA. Phenotypic characterization of γδ T cells mobilized in response to acute psychological stress. Brain Behav Immun. 2010;24(4):608–14.
Article
CAS
PubMed
Google Scholar
Sallusto F, Geginat J, Lanzavecchia A. Central memory and effector memory T cell subsets: function, generation, and maintenance. Annu Rev Immunol. 2004;22:745–63.
Article
CAS
PubMed
Google Scholar
Farber DL, Yudanin NA, Restifo NP. Human memory T cells: generation, compartmentalization and homeostasis. Nat Rev Immunol. 2014;14(1):24–35.
Article
PubMed Central
CAS
PubMed
Google Scholar
Henson SM, Akbar AN. KLRG1—more than a marker for T cell senescence. Age. 2009;31(4):285–91.
Article
PubMed Central
CAS
PubMed
Google Scholar
Blackburn SD, Shin H, Haining WN, Zou T, Workman CJ, Polley A, et al. Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection. Nat Immunol. 2008;10(1):29–37.
Article
PubMed Central
PubMed
Google Scholar
Curriu M, Carrillo J, Massanella M, Rigau J, Alegre J, Puig J, et al. Screening NK-B-and T-cell phenotype and function in patients suffering from Chronic Fatigue Syndrome. J Transl Med. 2013;11:68.
Article
PubMed Central
CAS
PubMed
Google Scholar
Estefanía E, Flores R, Gómez-Lozano N, Aguilar H, López-Botet M, Vilches C. Human KIR2DL5 is an inhibitory receptor expressed on the surface of NK and T lymphocyte subsets. J Immunol. 2007;178(7):4402–10.
Article
PubMed
Google Scholar
Cisneros E, Moraru M, Gómez-Lozano N, López-Botet M, Vilches C. KIR2DL5: an orphan inhibitory receptor displaying complex patterns of polymorphism and expression. Front Immunol. 2012;3.
Vilches C, Rajalingam R, Uhrberg M, Gardiner CM, Young NT, Parham P. KIR2DL5, a novel killer-cell receptor with a D0-D2 configuration of Ig-like domains. J Immunol. 2000;164(11):5797–804.
Article
CAS
PubMed
Google Scholar
Hurchla MA, Sedy JR, Murphy KM. Unexpected role of B and T lymphocyte attenuator in sustaining cell survival during chronic allostimulation. J Immunol. 2007;178(10):6073–82.
Article
CAS
PubMed
Google Scholar
Nielsen N, Ødum N, Ursø B, Lanier LL, Spee P. Cytotoxicity of CD56bright NK cells towards autologous activated CD4+ T cells is mediated through NKG2D, LFA-1 and TRAIL and dampened via CD94/NKG2A. PLoS One. 2012;7(2), e31959.
Article
PubMed Central
CAS
PubMed
Google Scholar
Bryceson YT, March ME, Ljunggren HG, Long EO. Activation, coactivation, and costimulation of resting human natural killer cells. Immunol Rev. 2006;214(1):73–91.
Article
CAS
PubMed
Google Scholar
Lima M, Almeida J, dos Anjos TM, Queirós ML, Justiça B, Orfão A. The “< i > ex Vivo</i>” Patterns of CD2/CD7, CD57/CD11c, CD38/CD11b, CD45RA/CD45RO, and CD11a/HLA-DR Expression Identify Acute/Early and Chronic/Late NK-Cell Activation States. Blood Cell Mol Dis. 2002;28(2):181–90.
Article
Google Scholar
Glaser R, Kiecolt-Glaser JK. Stress-induced immune dysfunction: implications for health. Nat Rev Immunol. 2005;5(3):243–51.
Article
CAS
PubMed
Google Scholar
Bryant PA, Trinder J, Curtis N. Sick and tired: does sleep have a vital role in the immune system? Nat Rev Immunol. 2004;4(6):457–67.
Article
CAS
PubMed
Google Scholar
Üstün TB. Measuring health and disability: Manual for WHO disability assessment schedule WHODAS 2.0. In: World Health Organization. 2010.
Google Scholar
Ware Jr JE, Sherbourne CD. The MOS 36-item short-form health survey (SF-36): I. Conceptual framework and item selection. In: Medical care. 1992. p. 473–83.
Google Scholar
Montoya CJ, Pollard D, Martinson J, Kumari K, Wasserfall C, Mulder CB, et al. Characterization of human invariant natural killer T subsets in health and disease using a novel invariant natural killer T cell‐clonotypic monoclonal antibody, 6B11. Immunology. 2007;122(1):1–14.
Article
PubMed Central
CAS
PubMed
Google Scholar
Aguinis H, Gottfredson RK, Joo H. Best-practice recommendations for defining, identifying, and handling outliers. Organ Res Methods. 2013;16(2):270–301.
Article
Google Scholar