Pneumococcal vaccination responses in adults with subnormal IgG subclass concentrations

BMC Immunology

Table 3 Pneumococcal serotype-specific IgG responses and clinical variables in 59 adults with selective subnormal IgG3^a

S. pneumoniae Serotype	Variable	Frequency of dichotomous variables		P value
S. pneumoniae Serotype	Variable	Responders^b	Non-responders	P value
3	Atopy	0.4	1.3	0.009
4	Atopy	0	1.6	0.007
14	Atopy	0.1	1.3	0.005
56	Atopy	0	1.6	0.007
68	Atopy	0	1.6	0.007
1	Total variables	0.2	1.1	0.012
3	Total variables	0.1	1.6	0.003
14	Total variables	0.2	1.3	0.01

^aVariables were defined as: male; diabetes; autoimmune condition(s); atopy (allergic asthma, allergic rhinitis, or allergic dermatitis/eczema); and other allergy (urticaria, angioedema, or anaphylaxis). Frequency was calculated as the mean number of each variable or total variables per patient in polyvalent pneumococcal polysaccharide vaccination responders and non-responders
^bWe defined responders as patients who achieved protective levels of serotype-specific IgG post- polyvalent pneumococcal polysaccharide vaccination. We defined protective serotype-specific IgG levels as > 1.3 μg/mL

ISSN: 1471-2172