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Table 3 Pneumococcal serotype-specific IgG responses and clinical variables in 59 adults with selective subnormal IgG3a

From: Pneumococcal vaccination responses in adults with subnormal IgG subclass concentrations

S. pneumoniae Serotype Variable Frequency of dichotomous variables P value
Respondersb Non-responders
3 Atopy 0.4 1.3 0.009
4 Atopy 0 1.6 0.007
14 Atopy 0.1 1.3 0.005
56 Atopy 0 1.6 0.007
68 Atopy 0 1.6 0.007
1 Total variables 0.2 1.1 0.012
3 Total variables 0.1 1.6 0.003
14 Total variables 0.2 1.3 0.01
  1. aVariables were defined as: male; diabetes; autoimmune condition(s); atopy (allergic asthma, allergic rhinitis, or allergic dermatitis/eczema); and other allergy (urticaria, angioedema, or anaphylaxis). Frequency was calculated as the mean number of each variable or total variables per patient in polyvalent pneumococcal polysaccharide vaccination responders and non-responders
  2. bWe defined responders as patients who achieved protective levels of serotype-specific IgG post- polyvalent pneumococcal polysaccharide vaccination. We defined protective serotype-specific IgG levels as > 1.3 μg/mL