Pneumococcal vaccination responses in adults with subnormal IgG subclass concentrations

BMC Immunology

Table 4 Frequencies of variables that differed significantly between different IgG subclass deficiency subgroups^a

S. pneumoniae Serotype	Dichotomous variable^b	Frequency of variable			P value
S. pneumoniae Serotype	Dichotomous variable^b	IgG1	IgG3	IgG1 + IgG3	P value
Responders^b
1	Male	0.8	0	0.7	0.006
3	Male	0.8	0	0.7	0.006
14	Male	0	0	0.5	0.01
51	Male	0.8	0	0.7	0.006
Non-responders
4	Atopy	0.06	1.6	0	0.02
14	Atopy	0.17	1.3	0.2	0.04
56	Atopy	0.06	1.6	0	0.02
68	Atopy	0.06	1.6	0	0.02
3	Autoimmune condition(s)	0	1.6	0.2	0.02
51	Autoimmune condition(s)	0	1.6	0.2	0.02
19	Male	0.8	0.06	1	0.03
23	Male	0.8	0.06	1	0.03
3	Other allergy	0.4	1.3	0.4	0.04
51	Other allergy	0.4	1.3	0.4	0.04
14	Total variables	0.4	1.3	0.4	0.03

^aVariables were defined as: male; diabetes; autoimmune condition(s); atopy (allergic asthma, allergic rhinitis, or allergic dermatitis/eczema); and other allergy (urticaria, angioedema, or anaphylaxis). Frequency was calculated as the mean number of each variable or total variables per patient in polyvalent pneumococcal polysaccharide vaccination responders and non-responders. ^bWe defined responders as patients who achieved protective levels of serotype-specific IgG post-polyvalent pneumococcal polysaccharide vaccination. We defined protective serotype-specific IgG levels as >1.3 µg/mL

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