Skip to main content

Table 4 Frequencies of variables that differed significantly between different IgG subclass deficiency subgroupsa

From: Pneumococcal vaccination responses in adults with subnormal IgG subclass concentrations

S. pneumoniae Serotype Dichotomous variableb Frequency of variable P value
IgG1 IgG3 IgG1 + IgG3
Respondersb
 1 Male 0.8 0 0.7 0.006
 3 Male 0.8 0 0.7 0.006
 14 Male 0 0 0.5 0.01
 51 Male 0.8 0 0.7 0.006
Non-responders
 4 Atopy 0.06 1.6 0 0.02
 14 Atopy 0.17 1.3 0.2 0.04
 56 Atopy 0.06 1.6 0 0.02
 68 Atopy 0.06 1.6 0 0.02
 3 Autoimmune condition(s) 0 1.6 0.2 0.02
 51 Autoimmune condition(s) 0 1.6 0.2 0.02
 19 Male 0.8 0.06 1 0.03
 23 Male 0.8 0.06 1 0.03
 3 Other allergy 0.4 1.3 0.4 0.04
 51 Other allergy 0.4 1.3 0.4 0.04
 14 Total variables 0.4 1.3 0.4 0.03
  1. aVariables were defined as: male; diabetes; autoimmune condition(s); atopy (allergic asthma, allergic rhinitis, or allergic dermatitis/eczema); and other allergy (urticaria, angioedema, or anaphylaxis). Frequency was calculated as the mean number of each variable or total variables per patient in polyvalent pneumococcal polysaccharide vaccination responders and non-responders. bWe defined responders as patients who achieved protective levels of serotype-specific IgG post-polyvalent pneumococcal polysaccharide vaccination. We defined protective serotype-specific IgG levels as >1.3 µg/mL