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  1. Humanized mice (hu mice) are based on the transplantation of hematopoietic stem and progenitor cells into immunodeficient mice and have become important pre-clinical models for biomedical research. However, da...

    Authors: Annette Audigé, Mary-Aude Rochat, Duo Li, Sandra Ivic, Audrey Fahrny, Christina K. S. Muller, Gustavo Gers-Huber, Renier Myburgh, Simon Bredl, Erika Schlaepfer, Alexandra U. Scherrer, Stefan P. Kuster and Roberto F. Speck

    Citation: BMC Immunology 2017 18:28

    Content type: Research article

    Published on:

  2. We have previously reported that interleukin-10 (IL-10) deficient dendritic cells (DCs) are potent antigen presenting cells that induced elevated protective immunity against Chlamydia. To further investigate the ...

    Authors: Khamia Ryans, Yusuf Omosun, Danielle N. McKeithen, Tankya Simoneaux, Camilla C. Mills, Nathan Bowen, Francis O. Eko, Carolyn M. Black, Joseph U. Igietseme and Qing He

    Citation: BMC Immunology 2017 18:27

    Content type: Research article

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  3. T-helper cell type 1 (Th1) polarization in chronic immune thrombocytopenia (cITP) has been reported at the protein and mRNA levels. We evaluated the impact of Th1/Th2 cytokine and cytokine receptor functional ...

    Authors: Noriyuki Takahashi, Takayuki Saitoh, Nanami Gotoh, Yasuhiro Nitta, Lobna Alkebsi, Tetsuhiro Kasamatsu, Yusuke Minato, Akihiko Yokohama, Norifumi Tsukamoto, Hiroshi Handa and Hirokazu Murakami

    Citation: BMC Immunology 2017 18:26

    Content type: Research article

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  4. Porcine circovirus 2 (PCV2) is a small, non-enveloped DNA virus causing swine lymphocyte depletion and severe impact on the swine industry. The aim of this study was to evaluate the antigenicity and immunogeni...

    Authors: Ling-Chu Hung, Cheng-Yao Yang and Ivan-Chen Cheng

    Citation: BMC Immunology 2017 18:25

    Content type: Research article

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  5. Activation of inflammasome contributes to the clearance of intracellular bacteria. C-terminus of E. coli EscI protein can activate NLRC4 (NLR family, CARD domain containing-4) inflammasome in macrophages. The pur...

    Authors: Maozhi Hu, Weixin Zhao, Wei Gao, Wenhua Li, Chuang Meng, Qiuxiang Yan, Yuyang Wang, Xiaohui Zhou, Shizhong Geng, Zhiming Pan, Guiyou Cui and Xinan Jiao

    Citation: BMC Immunology 2017 18:21

    Content type: Research article

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  6. Delayed wound healing reduces the quality of life (QOL) of patients. Thus, understanding the mechanism of wound healing is indispensable for better management. However, the role of innate immunity in wound hea...

    Authors: Kazuhide Takada, Shihoko Komine-Aizawa, Naoko Hirohata, Quang Duy Trinh, Atsuyoshi Nishina, Hirokazu Kimura and Satoshi Hayakawa

    Citation: BMC Immunology 2017 18:19

    Content type: Research article

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  7. Type 1 diabetes is an autoimmune disease caused by T cell-mediated destruction of the insulin-producing β-cells in the pancreas. Therefore, approaches that effectively halt the pathogenic T cell response are p...

    Authors: Cristina Vazquez-Mateo, Justin Collins, Michelle Fleury and Hans Dooms

    Citation: BMC Immunology 2017 18:18

    Content type: Research article

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  8. To assess the impact of disease activity on health-related quality of life (HRQoL) in systemic lupus erythematosus (SLE).

    Authors: Benjamin Chaigne, Carlo Chizzolini, Thomas Perneger, Marten Trendelenburg, Uyen Huynh-Do, Eric Dayer, Thomas Stoll, Johannes von Kempis and Camillo Ribi

    Citation: BMC Immunology 2017 18:17

    Content type: Research article

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  9. Uncontrolled cytomegalovirus (CMV) replication in immunocompromised solid-organ transplant recipients is a clinically relevant issue and an indication of impaired CMV-specific cell-mediated immunity (CMI). Pri...

    Authors: Bernhard Banas, Carsten A. Böger, Gerhard Lückhoff, Bernd Krüger, Sascha Barabas, Julia Batzilla, Mathias Schemmerer, Josef Köstler, Hanna Bendfeldt, Anne Rascle, Ralf Wagner, Ludwig Deml, Joachim Leicht and Bernhard K. Krämer

    Citation: BMC Immunology 2017 18:15

    Content type: Research article

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  10. In healthy individuals, Cytomegalovirus (CMV) infection is efficiently controlled by CMV-specific cell-mediated immunity (CMI). Functional impairment of CMI in immunocompromized individuals however can lead to...

    Authors: Sascha Barabas, Theresa Spindler, Richard Kiener, Charlotte Tonar, Tamara Lugner, Julia Batzilla, Hanna Bendfeldt, Anne Rascle, Benedikt Asbach, Ralf Wagner and Ludwig Deml

    Citation: BMC Immunology 2017 18:14

    Content type: Methodology article

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  11. Japanese encephalitis virus (JEV) is a mosquito-borne flavivirus that causes Japanese Encephalitis (JE) and Acute Encephalitis Syndrome (AES) in humans. Genotype-I (as co-circulating cases with Genotype-III) w...

    Authors: Shyamashree Banerjee, Parth Sarthi Sen Gupta and Amal Kumar Bandyopadhyay

    Citation: BMC Immunology 2017 18:13

    Content type: Research article

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  12. Lipopolysaccharide (LPS) induces acute liver injury and the complex mechanisms include the activation of toll like receptor 4 (TLR4) signaling pathway in many species. However, immuno-pathological changes duri...

    Authors: Xi-Yao Huang, Abdur Rahman Ansari, Hai-Bo Huang, Xing Zhao, Ning-Ya Li, Zhi-Jian Sun, Ke-Mei Peng, Juming Zhong and Hua-Zhen Liu

    Citation: BMC Immunology 2017 18:12

    Content type: Research article

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  13. Tuberculosis (TB) is a major global public health problem. New treatment methods on TB are urgently demanded. In this study, Mycobacterium tuberculosis (MTB) rv2190c DNA vaccine was prepared and its immunogenicit...

    Authors: Yan Liang, Xiaoyan Zhang, Xuejuan Bai, Li Xiao, Xiaomei Wang, Junxian Zhang, Yourong Yang, Jinying Song, Lan Wang and Xueqiong Wu

    Citation: BMC Immunology 2017 18:11

    Content type: Research article

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  14. Allergy to cat epithelia is highly prevalent, being the major recommendation for allergy sufferers its avoidance. However, this is not always feasible. Allergen specific immunotherapy is therefore recommended ...

    Authors: María Morales, Mayte Gallego, Victor Iraola, Marta Taulés, Eliandre de Oliveira, Raquel Moya and Jerónimo Carnés

    Citation: BMC Immunology 2017 18:10

    Content type: Research article

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  15. Patients experiencing large thermal injuries are susceptible to opportunistic infections that can delay recovery and lead to sepsis. Dendritic cells (DC) are important for the detection of pathogens and activa...

    Authors: Leon Bae, Julia K. Bohannon, Weihua Cui, Monika Vinish and Tracy Toliver-Kinsky

    Citation: BMC Immunology 2017 18:9

    Content type: Research article

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  16. Hyperactive secretion and pathogenic effects of interleukin (IL)-17 and IgA have been detected in different arthropathies. Recent evidence has revealed that TH17 cytokines regulate mucosal IgA secretion. However,...

    Authors: Ricardo Javier Eliçabe, Juan Eduardo Silva, Mabel Noemí Dave, María Gabriela Lacoste, Héctor Tamashiro, Rodrigo Blas, Alicia Munarriz, Gabriel Adrián Rabinovich and María Silvia Di Genaro

    Citation: BMC Immunology 2017 18:8

    Content type: Research article

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  17. While tumor necrosis factor alpha (TNF-α) inhibitors (TNFi) and other biologics are very effective against autoimmune diseases, they can also cause infectious diseases. Therefore, it is important to clarify wh...

    Authors: Shoichi Fukui, Hideki Nakamura, Yoshiko Takahashi, Naoki Iwamoto, Hiroo Hasegawa, Katsunori Yanagihara, Tatsufumi Nakamura, Akihiko Okayama and Atsushi Kawakami

    Citation: BMC Immunology 2017 18:7

    Content type: Research article

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  18. Comprehensive understanding of cellular immune subsets involved in regulation of tumor progression is central to the development of cancer immunotherapies. Single cell immunophenotyping has historically been a...

    Authors: Elma Kadić, Raymond J. Moniz, Ying Huo, An Chi and Ilona Kariv

    Citation: BMC Immunology 2017 18:6

    Content type: Research article

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  19. The role of pathogen specific cellular immune responses against the eliciting pathogen in development of post-infectious chronic fatigue syndrome (PI-CFS) is not known and such studies are difficult to perform...

    Authors: Kurt Hanevik, Einar Kristoffersen, Kristine Mørch, Kristin Paulsen Rye, Steinar Sørnes, Staffan Svärd, Øystein Bruserud and Nina Langeland

    Citation: BMC Immunology 2017 18:5

    Content type: Research article

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  20. The spleen is an important site for hematopoiesis. It supports development of myeloid cells from bone marrow-derived precursors entering from blood. Myeloid subsets in spleen are not well characterised althoug...

    Authors: Ying-Ying Hey, Benjamin Quah and Helen C. O’Neill

    Citation: BMC Immunology 2017 18:4

    Content type: Research article

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  21. Oxidative damage present in obese/overweight mothers may lead to further oxidative stress conditions or inflammation in maternal and cord blood samples. Thirty-four pregnant women/newborn pairs were included i...

    Authors: María Hernández-Trejo, Araceli Montoya-Estrada, Yessica Torres-Ramos, Aurora Espejel-Núñez, Alberto Guzmán-Grenfell, Rosa Morales-Hernández, Maricruz Tolentino-Dolores and Estibalitz Laresgoiti-Servitje

    Citation: BMC Immunology 2017 18:3

    Content type: Research Article

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  22. CD4+CD25+ regulatory T (Treg) cells suppress tumor immunity by inhibiting immune cells. Manipulation of Treg cells represents a new strategy for cancer treatment. Zoledronic acid (ZA), a nitrogen-containing bisph...

    Authors: Hsien Liu, Shih-Han Wang, Shin-Cheh Chen, Ching-Ying Chen, Jo-Lin Lo and Tsun-Mei Lin

    Citation: BMC Immunology 2016 17:45

    Content type: Research article

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  23. The Luminex bead-based multiplex assay is useful for quantifying immune mediators such as cytokines and chemokines. Cross-comparisons of reagents for this technique from different suppliers have already been p...

    Authors: Mathieu Surenaud, Céline Manier, Laura Richert, Rodolphe Thiébaut, Yves Levy, Sophie Hue and Christine Lacabaratz

    Citation: BMC Immunology 2016 17:44

    Content type: Methodology article

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  24. The Major Histocompatibility Complex (MHC) class I family of genes encode for molecules that have well-conserved structures, but have evolved to perform diverse functions. The availability of the gray, short-t...

    Authors: Katina V. Krasnec, Anthony T. Papenfuss and Robert D. Miller

    Citation: BMC Immunology 2016 17:43

    Content type: Research article

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  25. The small intestine is a specialized compartment were close interactions take place between host, microbes, food antigens and dietary fatty acids. Dietary fats get absorbed by epithelial cells and processed in...

    Authors: Jeroen van Bergenhenegouwen, Aletta D. Kraneveld, Lieke Rutten, Johan Garssen, Arjan P. Vos and Anita Hartog

    Citation: BMC Immunology 2016 17:42

    Content type: Research article

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  26. Although histone methyltransferases EZH2 has been proved to have significant regulatory effect on the immune rejection after hematopoietic stem cell transplantation, its role in solid-organ transplantation rem...

    Authors: Long Li, Yi Zhang, Ming Xu, Ruiming Rong, Jina Wang and Tongyu Zhu

    Citation: BMC Immunology 2016 17:41

    Content type: Research article

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  27. Circulating follicular helper T (Tfh) cells are a heterogeneous population of CD4+ helper T cells that promotes pathogenic immune responses in autoimmune diseases. In this study, we examined the status of differe...

    Authors: Deying Liu, Jinxiang Liu, Jinghua Wang, Congcong Liu, Sirui Yang and Yanfang Jiang

    Citation: BMC Immunology 2016 17:40

    Content type: Research article

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  28. Vaccination generating a robust memory population of CD8+ T cells may provide protection against cancer. However, immune therapies for cancer are influenced by the local tumour immune microenvironment. An infiltr...

    Authors: Andrew J. Highton, Adam Girardin, Georgia M. Bell, Sarah M. Hook and Roslyn A. Kemp

    Citation: BMC Immunology 2016 17:39

    Content type: Research article

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  29. High-throughput sequencing of T cell receptor (TCR) genes is a powerful tool for analyses of antigen specificity, clonality and diversity of T lymphocytes. Here, we developed a new TCR repertoire analysis meth...

    Authors: Kazutaka Kitaura, Tadasu Shini, Takaji Matsutani and Ryuji Suzuki

    Citation: BMC Immunology 2016 17:38

    Content type: Research article

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  30. Toxoplasma gondii is an opportunistic protozoan closely associated with AIDS and vertical transmission. T. gondii actin depolymerizing factor (TgADF) plays an important role in actin c...

    Authors: Zhuanzhuan Liu, Litian Yin, Yaqing Li, Fei Yuan, Xiaofan Zhang, Jiazhi Ma, Hongmei Liu, Yanjuan Wang, Kuiyang Zheng and Jianping Cao

    Citation: BMC Immunology 2016 17:37

    Content type: Research article

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  31. Bladder cancer, cystitis and bladder polyp are the most common urinary system diseases all over the world. Our former research results show that IL-17A and IL-17 F contribute to the pathogenesis of benign pros...

    Authors: Yanbo Liu, Wanguo Yang, Lijing Zhao, Zuowen Liang, Weigao Shen, Qinlong Hou, Zhenjiang Wang, Jing Jiang and Sun Ying

    Citation: BMC Immunology 2016 17:36

    Content type: Research article

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  32. Cytomegalovirus seropositivity is an independent risk factor for atherosclerosis in patients with ESRD. Donor CMV seropositivity is associated with higher graft loss. Dendritic cells, macrophages and Th17 lymp...

    Authors: Mahmoud Sadeghi, Imad Lahdou, Gerhard Opelz, Arianeb Mehrabi, Martin Zeier, Paul Schnitzler and Volker Daniel

    Citation: BMC Immunology 2016 17:35

    Content type: Research article

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  33. Although Hizentra is indicated for immunoglobulin replacement therapy in patients with primary and secondary immunodeficiencies, phase III trials have focused on patients with primary immunodeficiencies. In th...

    Authors: J. F. Viallard, P. Agape, V. Barlogis, G. Cozon, C. Faure, F. Fouyssac, C. Gaud, M. P. Gourin, M. Hamidou, C. Hoarau, F. Husseini, M. Ojeda-Uribe, M. Pavic, I. Pellier, A. Perlat, N. Schleinitz…

    Citation: BMC Immunology 2016 17:34

    Content type: Research article

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  34. Fetuin-A/AHSH is a novel hepatokine that acts as a vascular calcification inhibitor and as an endogenous TLR-4 ligand. Fetuin-A may act as a positive or negative acute phase protein (APP) in disease conditions...

    Authors: Sardar Sindhu, Nadeem Akhter, Steve Shenouda, Ajit Wilson and Rasheed Ahmad

    Citation: BMC Immunology 2016 17:33

    Content type: Research article

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  35. In the context of tumor immunology, tumor cells have been shown to overexpress CD47, an anti-phagocytic signal directed to macrophages to escape from phagocytosis by interacting with Signal Regulatory Protein ...

    Authors: Gizem Bener, Alex J. Félix, Cristina Sánchez de Diego, Isabel Pascual Fabregat, Carlos J. Ciudad and Véronique Noé

    Citation: BMC Immunology 2016 17:32

    Content type: Research article

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  36. Despite recent advances in early detection and improvements in chemotherapy for colon cancer, the patients still face poor prognosis of postoperative recurrence and metastasis, the median survival for patients...

    Authors: Huanyu Ju, Wenjing Xing, Jinfeng Yang, Yang Zheng, Xiuzhi Jia, Benning Zhang and Huan Ren

    Citation: BMC Immunology 2016 17:31

    Content type: Research article

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  37. Interleukin-15 is an immunostimulatory cytokine overexpressed in several autoimmune and inflammatory diseases such as Rheumatoid Arthritis, psoriasis and ulcerative colitis; thus, inhibition of IL-15-induced s...

    Authors: Yunier Rodríguez-Álvarez, Yanelys Morera-Díaz, Haydee Gerónimo-Pérez, Jorge Castro-Velazco, Rafael Martínez-Castillo, Pedro Puente-Pérez, Vladimir Besada-Pérez, Eugenio Hardy-Rando, Araceli Chico-Capote, Klaudia Martínez-Cordovez and Alicia Santos-Savio

    Citation: BMC Immunology 2016 17:30

    Content type: Research article

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  38. Recently, the immunostimulatory roles of chemotherapeutics have been increasingly revealed, although bone marrow suppression is still a common toxicity of chemotherapy. While the numbers and ratios of differen...

    Authors: Yanhong Wu, Zhenling Deng, Huiru Wang, Wenbo Ma, Chunxia Zhou and Shuren Zhang

    Citation: BMC Immunology 2016 17:29

    Content type: Research article

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  39. The purpose of this study was to characterize specific cytotoxic T-cell (CTL) responses in men who have sex with men (MSM) subjects infected with the human immunodeficiency virus type 1 (HIV-1) CRF01_AE subtyp...

    Authors: Fanming Jiang, Xiaoxu Han, Hui Zhang, Bin Zhao, Minghui An, Junjie Xu, Zhenxing Chu, Tao Dong and Hong Shang

    Citation: BMC Immunology 2016 17:28

    Content type: Research article

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  40. The lung is exposed to airborne fungal spores, and fungi that colonize the oral cavity such as Candida albicans, but does not develop disease to opportunistic fungal pathogens unless the immune system is compromi...

    Authors: Sabarirajan Jayaraja, Azzeddine Dakhama, Bogeon Yun, Moumita Ghosh, HeeJung Lee, Elizabeth F. Redente, Charis L. Uhlson, Robert C. Murphy and Christina C. Leslie

    Citation: BMC Immunology 2016 17:27

    Content type: Research article

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  41. Capparis Spinosa L. is an aromatic plant growing wild in dry regions around the Mediterranean basin. Capparis Spinosa was shown to possess several properties such as antioxidant, antif...

    Authors: Mouna Moutia, Khadija El Azhary, Anass Elouaddari, Abdellah Al Jahid, Jamal Jamal Eddine, Fouad Seghrouchni, Norddine Habti and Abdallah Badou

    Citation: BMC Immunology 2016 17:26

    Content type: Research article

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  42. The mouse strain BALB/c deficient in IL-1 receptor antagonist protein (Il-1ra) develops spontaneous arthritis disease (SAD) while the strain DBA/1 IL1rn -/- with the same deficiency doe...

    Authors: Xiaoyun Liu, Yan Jiao, Yanhong Cao, Nan Deng, Yonghui Ma, Karen A. Hasty, Andrew Kang, Hong Chen, John M. Stuart and Weikuan Gu

    Citation: BMC Immunology 2016 17:25

    Content type: Research article

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  43. Major histocompatibility complex class I (MHCI) proteins present antigenic peptides for immune surveillance and play critical roles in nervous system development and plasticity. Most MHCI are transmembrane pro...

    Authors: Karla K. Frietze, Adlai L. Pappy II, Jack W. Melson, Emily E. O’Driscoll, Carolyn M. Tyler, David H. Perlman and Lisa M. Boulanger

    Citation: BMC Immunology 2016 17:24

    Content type: Research article

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  44. Adoptive transfer of genetically engineered autologous T-cells is becoming a successful therapy for cancer. The avidity of the engineered T-cells is of crucial importance for therapy success. We have in the pa...

    Authors: Victoria Hillerdal, Vanessa F. Boura, Hanna Björkelund, Karl Andersson and Magnus Essand

    Citation: BMC Immunology 2016 17:23

    Content type: Research article

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  45. Mast cells are hematopoietically derived cells that play a role in inflammatory processes such as allergy, as well as in the immune response against pathogens by the selective and rapid release of preformed an...

    Authors: Valéria Cintra Barbosa-Lorenzi, Nerry Tatiana Cecilio, Patricia Andressa de Almeida Buranello, Maria Cristina Pranchevicius, Maria Helena S. Goldman, Gabriela Pereira-da-Silva, Maria Cristina Roque-Barreira, Maria Célia Jamur and Constance Oliver

    Citation: BMC Immunology 2016 17:22

    Content type: Research article

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  46. Immunobiotic Lactobacillus jensenii TL2937 modulates porcine mononuclear phagocytes from Peyer’s patches (PPMPs) and induces a differential production of pro- and anti-inflammatory cytokines in response to Toll-l...

    Authors: Kohichiro Tsukida, Takuya Takahashi, Hikaru Iida, Paulraj Kanmani, Yoshihito Suda, Tomonori Nochi, Shuichi Ohwada, Hisashi Aso, Sou Ohkawara, Seiya Makino, Hiroshi Kano, Tadao Saito, Julio Villena and Haruki Kitazawa

    Citation: BMC Immunology 2016 17:21

    Content type: Research article

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  47. Children are prone to get infections, especially in the respiratory system and the gut mainly because their immune system is immature. T cells significantly contribute to the prevention of infections, and diff...

    Authors: Erxia Shen, Mengjie Wang, Hairui Xie, Ruqiong Zou, Qiwen Lin, Lili lai, Fujun Li, Zhimei Liang, Yanran Xu and Maohua Zhou

    Citation: BMC Immunology 2016 17:20

    Content type: Research article

    Published on:

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