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1181 result(s) for 'immunology' within BMC Immunology

Page 13 of 24

  1. Rapid and accurate diagnosis of individuals with SARS-CoV-2 infection is an effective way to prevent and control the spread of COVID-19. Although the detection of SARS‐CoV‐2 viral RNA by RT‐qPCR is the gold st...

    Authors: Kengo Nishimura, Hiroaki Kitazawa, Takashi Kawahata, Kosuke Yuhara, Takahiro Masuya, Toshihiro Kuroita, Kentarou Waki, Seiichi Koike, Masaharu Isobe and Nobuyuki Kurosawa
    Citation: BMC Immunology 2023 24:34
    Content type: Research Published on:

  2. MHC class I proteins are partly responsible for shaping the magnitude and focus of the adaptive cellular immune response. In humans, conventional wisdom suggests that the HLA-A, -B, and -C alleles are equally ...

    Authors: Justin M Greene, Roger W Wiseman, Simon M Lank, Benjamin N Bimber, Julie A Karl, Benjamin J Burwitz, Jennifer J Lhost, Oriana E Hawkins, Kevin J Kunstman, Karl W Broman, Steven M Wolinsky, William H Hildebrand and David H O'Connor
    Citation: BMC Immunology 2011 12:39
    Content type: Research article Published on:

  3. Tumor-associated macrophages (TAMs) are the most abundant immune cells within the tumor stroma and play a crucial role in tumor development. Although clinical investigations indicate that high levels of macrop...

    Authors: Benfan Wang, Qinyan Li, Li Qin, Siting Zhao, Jinyan Wang and Xiaoping Chen
    Citation: BMC Immunology 2011 12:43
    Content type: Research article Published on:

  4. Current research suggests that the glial scar surrounding penetrating brain injuries is instrumental in preserving the surrounding uninjured tissue by limiting the inflammatory response to the injury site. We ...

    Authors: Kazadi Nadine Mutoji, Mingxia Sun, Amanda Nash, Sudan Puri, Vincent Hascall and Vivien J. Coulson-Thomas
    Citation: BMC Immunology 2021 22:52
    Content type: Research article Published on:

  5. In vitro studies have shown that the active form of vitamin D3, 1a,25-dihydroxyvitamin D3 (1,25(OH)2D3), can regulate differentiation of CD4+ T cells by inhibiting Th1 and Th17 cell differentiation and promoting ...

    Authors: Martin Kongsbak, Marina Rode von Essen, Trine Bøegh Levring, Peter Schjerling, Anders Woetmann, Niels Ødum, Charlotte Menné Bonefeld and Carsten Geisler
    Citation: BMC Immunology 2014 15:35
    Content type: Research article Published on:

  6. Cytokine mRNA quantification is widely used to investigate cytokine profiles, particularly in small samples. Real-time polymerase chain reaction is currently the most reliable method of quantifying low-level t...

    Authors: André Peinnequin, Catherine Mouret, Olivier Birot, Antonia Alonso, Jacques Mathieu, Didier Clarençon, Diane Agay, Yves Chancerelle and Eric Multon
    Citation: BMC Immunology 2004 5:3
    Content type: Methodology article Published on:

  7. Hypoxia is a potent molecular signal for cellular metabolism, mitochondrial function, and migration. Conditions of low oxygen tension trigger regulatory cascades mediated via the highly conserved HIF-1 α post-tra...

    Authors: Shannon P Hilchey, Mukta G Palshikar, Jason A Emo, Dongmei Li, Jessica Garigen, Jiong Wang, Eric S Mendelson, Valentina Cipolla, Juilee Thakar and Martin S Zand
    Citation: BMC Immunology 2020 21:13
    Content type: Research Article Published on:

  8. Type I hypersensitivity is characterized by the overreaction of the immune system against otherwise innocuous substances. It manifests as allergic rhinitis, allergic conjunctivitis, allergic asthma or atopic d...

    Authors: Ines Lindner, Christiane Meier, Angelika Url, Hermann Unger, Andreas Grassauer, Eva Prieschl-Grassauer and Petra Doerfler
    Citation: BMC Immunology 2010 11:24
    Content type: Research article Published on:

  9. Prosthetic joint infection (PJI) is an important failure mechanism of total joint arthroplasty (TJA). Here we examine whether the particular genetic variants can lead to increased susceptibility to PJI develop...

    Authors: Anna Stahelova, Frantisek Mrazek, Matej Smizansky, Martin Petrek and Jiri Gallo
    Citation: BMC Immunology 2012 13:25
    Content type: Research article Published on:

  10. West Nile virus (WNV) persists in humans and several animal models. We previously demonstrated that WNV persists in the central nervous system (CNS) of mice for up to 6 months post-inoculation. We hypothesized...

    Authors: Barbara S Stewart, Valerie L Demarest, Susan J Wong, Sharone Green and Kristen A Bernard
    Citation: BMC Immunology 2011 12:6
    Content type: Research article Published on:

  11. The natural antibody responses to B-cell epitopes from dengue structural proteins were assessed using immune sera from people having well-defined past dengue infections with one of the four serotypes.

    Authors: Mahesha N. Nadugala, Chandima Jeewandara, Ramesh S. Jadi, Gathsaurie N. Malavige, Aravinda M. de Silva, Prasad H. Premaratne and Charitha L. Goonasekara
    Citation: BMC Immunology 2021 22:71
    Content type: Research Published on:

  12. The reconstruction of clonal families (CFs) in B-cell receptor (BCR) repertoire analysis is a crucial step to understand the adaptive immune system and how it responds to antigens. The BCR repertoire of an ind...

    Authors: Daria Balashova, Barbera D. C. van Schaik, Maria Stratigopoulou, Jeroen E. J. Guikema, Tom G. Caniels, Mathieu Claireaux, Marit J. van Gils, Anne Musters, Dornatien C. Anang, Niek de Vries, Victor Greiff and Antoine H. C. van Kampen
    Citation: BMC Immunology 2024 25:13
    Content type: Research Published on:

  13. Food proteins differ in their allergenic potential. Currently, there is no predictive and validated bio-assay to evaluate the allergenicity of novel food proteins. The objective of this study was to investigat...

    Authors: Mark Smits, Marjolein Meijerink, Thuy-My Le, André Knulst, Aard de Jong, Martinus Petrus Maria Caspers, Everton Souto Lima, Lilia Babé, Gregory Ladics, Scott McClain, Geert Houben and Kitty Verhoeckx
    Citation: BMC Immunology 2021 22:27
    Content type: Research article Published on:

  14. Blomia tropicalis is a dust mite and an important source of allergens in tropical regions. Up to now, the assays to diagnose atopy to this mite use whole body extract as antigens. However, anti-B. tropicalis IgE ...

    Authors: Kellyanne dos Anjos Carvalho, Osvaldo Pompílio de Melo-Neto, Franklin Barbalho Magalhães, João Carlos Marques Ponte, Filipe Adriano Borba Felipe, Mariese Conceição Alves dos Santos, Givaneide dos Santos Lima, Álvaro Augusto Cruz, Carina Silva Pinheiro, Lain Carlos Pontes-de-Carvalho and Neuza Maria Alcantara-Neves
    Citation: BMC Immunology 2013 14:11
    Content type: Research article Published on:

  15. Antineutrophil Cytoplasmic Antibodies (ANCA) associated glomerulonephritis (AGN) is a group of autoimmune diseases and mono-macrophages are involved in its glomerular injuries. In this study, we aim to investi...

    Authors: Xiao-Ning An, Zhao-Nan Wei, Yin-Yin Xie, Jing Xu, Yan Shen, Li-Yan Ni, Hao Shi, Ping-Yan Shen, Wen Zhang and Yong-Xi Chen
    Citation: BMC Immunology 2022 23:55
    Content type: Research Published on:

  16. The first exposure to microorganisms at mucosal surfaces is critical for immune maturation and gut health. Facultative anaerobic bacteria are the first to colonise the infant gut, and the impact of these bacte...

    Authors: Louise H Zeuthen, Lisbeth N Fink, Stine B Metzdorff, Matilde B Kristensen, Tine R Licht, Christine Nellemann and Hanne Frøkiær
    Citation: BMC Immunology 2010 11:2
    Content type: Research article Published on:

  17. Macrophages, osteoclasts, dendritic cells, and microglia are highly specialized cells that belong to the mononuclear phagocyte system. Functional and phenotypic heterogeneity within the mononuclear phagocyte s...

    Authors: Christine Servet-Delprat, Sylvie Arnaud, Pierre Jurdic, Serge Nataf, Marie-France Grasset, Caroline Soulas, Chantal Domenget, Olivier Destaing, Aymeric Rivollier, Magali Perret, Christiane Dumontel, Daniel Hanau, Gary L Gilmore, Marie-Françoise Belin, Chantal Rabourdin-Combe and Guy Mouchiroud
    Citation: BMC Immunology 2002 3:15
    Content type: Research article Published on:

  18. Preeclampsia is a severe complication of pregnancy characterized by an excessive maternal systemic inflammatory response with activation of both the innate and adaptive arms of the immune system. Cytokines, ch...

    Authors: András Szarka, János Rigó Jr, Levente Lázár, Gabriella Bekő and Attila Molvarec
    Citation: BMC Immunology 2010 11:59
    Content type: Research article Published on:

  19. Bone morphogenetic proteins (BMPs) belong to the TGF-β superfamily and are secreted proteins with pleiotropic roles in many different cell types. A potential role of BMP-6 in the immune system has been implied...

    Authors: Christian Kersten, Einar A Sivertsen, Marit E Hystad, Lise Forfang, Erlend B Smeland and June H Myklebust
    Citation: BMC Immunology 2005 6:9
    Content type: Research article Published on:

  20. There are three major B-cell compartments in peripheral lymphoid organs: the germinal center (GC), the mantle zone (MNZ) and the marginal zone (MGZ). Unique sets of B-cells reside in these compartments, and th...

    Authors: Yulei Shen, Javeed Iqbal, Li Xiao, Ryan C Lynch, Andreas Rosenwald, Louis M Staudt, Simon Sherman, Karen Dybkaer, Guimei Zhou, James D Eudy, Jan Delabie, Timothy W McKeithan and Wing C Chan
    Citation: BMC Immunology 2004 5:20
    Content type: Research article Published on:

  21. In rural Gambia, birth season predicts infection-related adult mortality, providing evidence that seasonal factors in early life may programme immune development. This study tested whether lymphocyte subpopula...

    Authors: Andrew C Collinson, Pa Tamba Ngom, Sophie E Moore, Gareth Morgan and Andrew M Prentice
    Citation: BMC Immunology 2008 9:18
    Content type: Research article Published on:

  22. Recent outbreaks of Zika Virus (ZIKV) infection and associated microcephaly has raised multiple scientific questions. The close antigenic relatedness between flaviviruses makes diagnosis of specific infection ...

    Authors: Himanshu Garg, Rose Yeh, Douglas M. Watts, Tugba Mehmetoglu-Gurbuz, Robert Resendes, Bruce Parsons, Fernando Gonzales and Anjali Joshi
    Citation: BMC Immunology 2021 22:5
    Content type: Research article Published on:

  23. To investigate the association of human leukocyte antigen (HLA)-DRB1 alleles and the variations of polymorphic amino acid changes in DRβ1 chain in Shaanxi Han population with Occult hepatitis B infection (OBI).

    Authors: Tianju Wang, Chunmei Shen, Hengxin Li, Liping Chen, Sheng Liu and Jun Qi
    Citation: BMC Immunology 2022 23:22
    Content type: Research Published on:

  24. The milk-derived protein human Casein alpha s1 (CSN1S1) has recently been detected in blood cells and was shown to possess proinflammatory properties. In the present study, we investigated the effect of CSN1S1...

    Authors: Stefan Vordenbäumen, Achim Braukmann, Irina Altendorfer, Ellen Bleck, Joachim Jose and Matthias Schneider
    Citation: BMC Immunology 2013 14:46
    Content type: Research article Published on:

  25. Chlamydia trachomatis infection results in reproductive damage in some women. The process and factors involved in this immunopathology are not well understood. This study aimed to investigate the role of primary ...

    Authors: Kelly Cunningham, Scott H Stansfield, Pooja Patel, Shruti Menon, Vivian Kienzle, John A Allan and Wilhelmina M Huston
    Citation: BMC Immunology 2013 14:50
    Content type: Research article Published on:

  26. The progression of acute-to-chronic atopic dermatitis is accompanied by multiple helper T-cell cytokine responses, but the mechanisms and relative importance of these changes remain unclear. There is no animal...

    Authors: Pengju Jiang, Yaguang Wu, Lu Liu, Lian Zhang and Zhiqiang Song
    Citation: BMC Immunology 2022 23:60
    Content type: Research Published on:

  29. Elevated levels of extracellular adenosine triphosphate (ATP) modulate immunologic pathways and are considered to be a danger signal in inflammation, lung fibrosis and cancer. Macrophages can be classified int...

    Authors: Benedikt F. Scherr, Martin F. Reiner, Flavia Baumann, Kerstin Höhne, Tobias Müller, Korcan Ayata, Joachim Müller-Quernheim, Marco Idzko and Gernot Zissel
    Citation: BMC Immunology 2023 24:11
    Content type: Research Published on:

  30. CIGB-247 is a cancer therapeutic vaccine that uses as antigen a variant of human vascular endothelial growth factor (VEGF) mixed with the bacterially-derived adjuvant VSSP. CIGB-247 has been already evaluated ...

    Authors: Javier Sánchez Ramírez, Yanelys Morera Díaz, Mónica Bequet-Romero, Francisco Hernández-Bernal, Yenima Martín Bauta, Katty-Hind Selman-Housein Bernal, Ana Victoria de la Torre Santos, Mariela Pérez de la Iglesia, Lian Trimiño Lorenzo and Marta Ayala Avila
    Citation: BMC Immunology 2020 21:12
    Content type: Research article Published on:

  31. Recent experimental approaches have unraveled essential migratory and functional differences of monocyte subpopulations in mice. In order to possibly translate these findings into human physiology and pathophy...

    Authors: Sebastian Seidler, Henning W Zimmermann, Matthias Bartneck, Christian Trautwein and Frank Tacke
    Citation: BMC Immunology 2010 11:30
    Content type: Research article Published on:

  32. Upon stimulation with different cytokines, macrophages can undergo classical or alternative activation to become M1 or M2 macrophages. Alternatively activated (or M2) macrophages are defined by their expressio...

    Authors: Dapeng Gong, Wei Shi, Sun-ju Yi, Hui Chen, John Groffen and Nora Heisterkamp
    Citation: BMC Immunology 2012 13:31
    Content type: Research article Published on:

  34. Leptospirosis is a zoonotic disease caused by Leptospira species. Variations in lipopolysaccharide (LPS) structure in Leptospira are known to be associated with the serovar diversity and antigenicity. Development...

    Authors: Dakshika Gangani, Wathsala Dissanayake, Rajiva de Silva, Kaushalya Anuradha, Lilani Karunanayake, Narmada Fernando, Senaka Rajapakse, Sunil Premawansa and Shiroma Handunnetti
    Citation: BMC Immunology 2023 24:39
    Content type: Research Published on:

  35. Although immunoglobulin A nephropathy (IgAN) is one of the foremost primary glomerular disease, treatment of IgAN is still in infancy. Non-invasive biomarkers are urgently needed for IgAN diagnosis. We investi...

    Authors: Na Guo, Qin Zhou, Xiang Huang, Jianwen Yu, Qianqian Han, Baoting Nong, Yuanyan Xiong, Peifen Liang, Jiajia Li, Min Feng, Jun Lv and Qiongqiong Yang
    Citation: BMC Immunology 2020 21:16
    Content type: Research article Published on:

  36. Innate lymphoid cells (ILC) are lymphoid lineage innate immune cells that do not mount antigen-specific responses due to their lack of B and T-cell receptors. ILCs are predominantly found at mucosal surfaces, ...

    Authors: Rose Nabatanzi, Lois Bayigga, Stephen Cose, Glenda Canderan, Sarah Rowland Jones, Moses Joloba and Damalie Nakanjako
    Citation: BMC Immunology 2021 22:59
    Content type: Research Published on:

  37. Tumor necrosis factor (TNFA) is the canonical member of the TNF superfamily, which plays a major role in both inflammation and apoptosis. To evaluate the role of TNFs in otitis media (OM), the most common dise...

    Authors: Joerg Ebmeyer, Anke Leichtle, Michelle Hernandez, Umay Ebmeyer, Jacob Husseman, Kwang Pak, Holger Sudhoff, David Broide, Stephen I Wasserman and Allen F Ryan
    Citation: BMC Immunology 2011 12:12
    Content type: Research article Published on:

  38. . Lack of exposure to the natural microbial diversity of the environment has been linked to dysregulation of the immune system and numerous noncommunicable diseases, such as allergies and autoimmune disorders....

    Authors: Laura Kummola, Martín I. González-Rodríguez, Pertti Marnila, Noora Nurminen, Tanja Salomaa, Lotta Hiihtola, Iida Mäkelä, Olli H. Laitinen, Heikki Hyöty, Aki Sinkkonen and Ilkka S. Junttila
    Citation: BMC Immunology 2023 24:29
    Content type: Research Published on:

  39. The immune response to trauma has traditionally been modeled to consist of the systemic inflammatory response syndrome (SIRS) followed by the compensatory anti-inflammatory response syndrome (CARS). We investi...

    Authors: Kevin R Kasten, Holly S Goetzman, Maria R Reid, Alison M Rasper, Samuel G Adediran, Chad T Robinson, Cindy M Cave, Joseph S Solomkin, Alex B Lentsch, Jay A Johannigman and Charles C Caldwell
    Citation: BMC Immunology 2010 11:4
    Content type: Research article Published on:

  41. Catecholamines, such as epinephrine, are elaborated in stress responses, and mediate vasoconstriction to cause elevation in systemic vascular resistance and blood pressure. Our previous study has shown that IL...

    Authors: David S Chi, S Matthew Fitzgerald, Shannon Pitts, Karen Cantor, Ellis King, Steven A Lee, Shau-Ku Huang and Guha Krishnaswamy
    Citation: BMC Immunology 2004 5:22
    Content type: Research article Published on:

  42. The local tissue microenvironment plays an important role in the induction, homing, maintenance and development of effector functions of T cells. Thus, site-specific differences in phenotypes of mucosal and sy...

    Authors: Joyce A Ibana, Leann Myers, Constance Porretta, Maria Lewis, Stephanie N Taylor, David H Martin and Alison J Quayle
    Citation: BMC Immunology 2012 13:66
    Content type: Research article Published on:

  43. The T cell attracting chemokine CCL18 is produced by antigen presenting cells and a role for CCL18 has been suggested in the pathogenesis of a variety of diseases. Rheumatoid arthritis (RA) is one of these con...

    Authors: Antoine WT van Lieshout, Robbert van der Voort, Linda MP le Blanc, Mieke F Roelofs, B Willem Schreurs, Piet LCM van Riel, Gosse J Adema and Timothy RDJ Radstake
    Citation: BMC Immunology 2006 7:23
    Content type: Research article Published on:

  44. Liver failure, which is predominantly caused by hepatitis B (HBV) can be improved by an artificial liver support system (ALSS). This study investigated the phenotypic heterogeneity of immunocytes in patients w...

    Authors: Tao Ju, Daixi Jiang, Chengli Zhong, Huafen Zhang, Yandi Huang, Chunxia Zhu, Shigui Yang and Dong Yan
    Citation: BMC Immunology 2023 24:47
    Content type: Research Published on:

  45. ATG has been employed to deplete T cells in several immune-mediated conditions. However, whether ATG administration affects naïve and memory T cell differently is largely unknown.

    Authors: Chang-Qing Xia, Anna V Chernatynskaya, Clive H Wasserfall, Suigui Wan, Benjamin M Looney, Scott Eisenbeis, John Williams, Michael J Clare-Salzler and Mark A Atkinson
    Citation: BMC Immunology 2012 13:70
    Content type: Research article Published on:

  46. Near universal administration of vaccines mandates intense pharmacovigilance for vaccine safety and a stringently low tolerance for adverse events. Reports of autoimmune diseases (AID) following vaccination ha...

    Authors: Peter B McGarvey, Baris E Suzek, James N Baraniuk, Shruti Rao, Brian Conkright, Samir Lababidi, Andrea Sutherland, Richard Forshee and Subha Madhavan
    Citation: BMC Immunology 2014 15:61
    Content type: Research article Published on:

  47. Umbilical cord blood (UCB) is enriched with transplantable CD34+ cells. In addition to CD34-expressing haematopoietic stem cells (HSC), human UCB contains a rare population of CD34-lineage- cells endowed with the...

    Authors: Giuseppina Bonanno, Andrea Mariotti, Annabella Procoli, Maria Corallo, Giovanni Scambia, Luca Pierelli and Sergio Rutella
    Citation: BMC Immunology 2009 10:46
    Content type: Research article Published on:

  48. T cell activation is associated with increase in glycolysis and glutaminolysis. T cell immunoglobulin and mucin domain containing protein-3 (TIM-3), a T cell surface molecule, downregulates T cell activation a...

    Authors: Mi Jin Lee, Su Jin Yun, Bokyoung Lee, Eun Jeong, Gyesoon Yoon, Kyongmin Kim and Sun Park
    Citation: BMC Immunology 2020 21:48
    Content type: Research article Published on:

  49. In lymphocyte subsets, expression of CD56 (neural cell adhesion molecule-1) correlates with cytotoxic effector activity. For cells bearing the Vγ2Vδ2 T cell receptor, isoprenoid pyrophosphate stimulation leads...

    Authors: Elizabeth M Urban, Haishan Li, Cheryl Armstrong, Chiara Focaccetti, Cristiana Cairo and C David Pauza
    Citation: BMC Immunology 2009 10:50
    Content type: Research article Published on:

  50. HIV eradication efforts have been unsuccessful partly due to virus persistence in immune sanctuary sites such as germinal centres within lymph node (LN) tissues. Recent evidence suggests that LNs harbour a nov...

    Authors: Bongiwe Mahlobo, Faatima Laher, Werner Smidt, Funsho Ogunshola, Trevor Khaba, Thandeka Nkosi, Anele Mbatha, Thandekile Ngubane, Krista Dong, Ismail Jajbhay, Johan Pansegrouw and Zaza M. Ndhlovu
    Citation: BMC Immunology 2022 23:34
    Content type: Research Published on:

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BMC Immunology

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