Kao CC, Huang JL, Ou LS, See LC: The prevalence, severity and seasonal variations of asthma, rhinitis and eczema in Taiwanese schoolchildren. Pediatr Allergy Immunol. 2005, 16: 408-415. 10.1111/j.1399-3038.2005.00268.x.
Article
PubMed
Google Scholar
Larche M, Robinson DSD, Kay AB: The role of the T lymphocytes in the pathogenesis of asthma. J Allergy Clin Immunol. 2003, 111: 450-63. 10.1067/mai.2003.169.
Article
PubMed
CAS
Google Scholar
Miyazaki T, Nishijima M: Studies on fungal polysaccharides, XXVII. Structural examination of a water-soluble, anti-tumor polysaccharide of Ganoderma lucidum. Chem Pharm Bull. 1981, 29: 3611-3616.
Article
PubMed
CAS
Google Scholar
Wang SY, Hsu ML, Hsu HC, Tzeng CH, Lee SS, Shiao MS, Ho CK: The anti-tumor effect of Ganoderma lucidum is mediated by cytokines released from activated macrophages and T lymphocytes. Int J Cancer. 1997, 70: 699-705. 10.1002/(SICI)1097-0215(19970317)70:6<699::AID-IJC12>3.0.CO;2-5.
Article
PubMed
CAS
Google Scholar
Furusawa E, Chou SC, Furusawa S, Hirazami A, Dang Y: Anti-tumor activity of Ganoderma lucidum, an edible mushroom, on intra-peritoneally implanted Lewis lung carcinoma in synergetic mice. Phytother Res. 1992, 6: 300-304. 10.1002/ptr.2650060604.
Article
Google Scholar
Zhang Q, Andoh T, Konno M, Lee JB, Hattori M, Kuraishi Y: Inhibitory effect of methanol extract of Ganoderma lucidum on acute itch-associated responses in mice. Biol Pharm Bull. 2010, 33: 909-11. 10.1248/bpb.33.909.
Article
PubMed
CAS
Google Scholar
Liu YH, Tsai CF, Kao MC, Lai YL, Tsai JJ: Effectiveness of Dp2 nasal therapy for Dp2-induced airway inflammation in mice: using oral Ganoderma lucidum as an immuno-modulator. J Microbiol Immunol Infect. 2003, 36: 236-42.
PubMed
Google Scholar
Kelly-Pieper K, Patil SP, Busse P, Yang N, Sampson H, Li XM, Wisnivesky JP, Kattan M: Safety and tolerability of an anti-asthma herbal formula (ASHMI) in adult subjects with asthma: A randomized, double-blinded, placebo-controlled, dose-escalation phase I study. J Alternat Complement Med. 2009, 15: 735-743. 10.1089/acm.2008.0543.
Article
Google Scholar
Bao XF, Wang XS, Dong Q, Fang JN, Li XY: Structural features of immunologically active polysaccharides from Ganoderma lucidum. Phytochemistry. 2002, 59: 175-181. 10.1016/S0031-9422(01)00450-2.
Article
PubMed
CAS
Google Scholar
Lee SS, Wei YH, Chen CF, Wang SY, Chen KY: Anti-tumor effects of Ganoderma lucidum. J Clin Med. 1995, 6: 1-12.
Google Scholar
Won SJ, Lee SS, Ke YH, Lin MT: Enhancement of splenic NK cytotoxic activity by extracts of Ganoderma lucidum mycelium in mice. J Biomed Lab Sci. 1989, 2: 201-213.
Google Scholar
Hsu MJ, Lee SS, Lin WW: Polysaccharide purified from Ganoderma lucidum inhibits spontaneous and Fas-mediated apoptosis in human neutrophils through activation of the phosphatidylinositol 3 kinase/Akt signaling pathway. J Leukoc Biol. 2002, 72: 207-216.
PubMed
CAS
Google Scholar
Lin YL, Liang YC, Lee SS, Chiang BL: Polysaccharide purified from Ganoderma lucidum induced activation and maturation of human monocyte-derived dendritic cells by the NF-kB and p38 mitogen-activated protein kinase pathways. J Leukoc Biol. 2005, 78: 533-543. 10.1189/jlb.0804481.
Article
PubMed
CAS
Google Scholar
Lin YL, Lee SS, Hou SM, Chiang BL: Polysaccharide purified from Ganoderma lucidum induces gene expression changes in human dendritic cells and promotes T helper 1 immune response in BALB/c mice. Mol Pharmacol. 2006, 70: 637-44. 10.1124/mol.106.022327.
Article
PubMed
CAS
Google Scholar
Banchereau J, Steinman RM: Dendritic cells and the control of immunity. Nature. 1998, 392: 245-252. 10.1038/32588.
Article
PubMed
CAS
Google Scholar
Pulendran B, Tang H, Denning TL: Division of labor, plasticity, and crosstalk between dendritic cell subsets. Curr Opin Immunol. 2008, 20: 61-67. 10.1016/j.coi.2007.10.009.
Article
PubMed
CAS
PubMed Central
Google Scholar
Cella M, Pinet Engering A, Pieters J, Lanzavecchia A: Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells. Nature. 1997, 388: 782-787. 10.1038/42030.
Article
PubMed
CAS
Google Scholar
Moore KW, Malefyt R, De W, Coffman RL, O'Garra A: Interleukin-10 and Interleukin-10 receptor. Annu Rev Immunol. 2001, 19: 683-765. 10.1146/annurev.immunol.19.1.683.
Article
PubMed
CAS
Google Scholar
Oppmann B, Lesley R, Blom B, et al: Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity. 2000, 13: 715-25. 10.1016/S1074-7613(00)00070-4.
Article
PubMed
CAS
Google Scholar
Aggarwal S, Ghilardi N, Xie MH, de Sauvage FJ, Gurney AL: Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17. J Biol Chem. 2003, 278: 1910-4. 10.1074/jbc.M207577200.
Article
PubMed
CAS
Google Scholar
Toda M, Leung DY, Molet S, Boguniewicz M, Taha R, Christodoulopoulos P, Fukuda T, Elias JA, Hamid QA: Polarized in vivo expression of IL-11 and IL-17 between acute and chronic skin lesions. J Allergy Clin Immunol. 2003, 111: 875-81. 10.1067/mai.2003.1414.
Article
PubMed
CAS
Google Scholar
Albanesi C, Cavani A, Girolomoni G: IL-17 is produced by nickel specific T lymphocytes and regulates ICAM-1 expression and chemokine production in human keratinocytes: synergistic or antagonist effects with IFN-gamma and TNF-alpha. J Immunol. 1999, 162: 494-502.
PubMed
CAS
Google Scholar
Gerosa F, Baldani-Guerra B, Lyakh LA, Batoni G, Esin S, Winkler-Pickett RT, Consolaro MR, De Marchi M, Giachino D, Robbiano A, et al: Differential regulation of interleukin 12 and interleukin 23 production in human dendritic cells 2. J Exp Med. 2008, 205: 1447-1461. 10.1084/jem.20071450.
Article
PubMed
CAS
PubMed Central
Google Scholar
Onari Y, Yokoyama A, Haruta Y, Nakashima T, Iwamoto H, Hattori N, Kohno N: IL-12p40 is essential for the down-regulation of airway hyperresponsiveness in a mouse model of bronchial asthma with prolonged antigen exposure. Clinical and Experimental Allergy. 2009, 39: 290-8. 10.1111/j.1365-2222.2008.03131.x.
Article
PubMed
CAS
Google Scholar
Huang D, Cancilla MR, Morahan G: Complete primary structure, chromosomal localisation, and definition of polymorphisms of the gene encoding the human interleukin-12 p40 subunit. Genes Immun. 2000, 1: 515-20. 10.1038/sj.gene.6363720.
Article
PubMed
CAS
Google Scholar
Morahan G, Huang D, Wu M, Holt BJ, White GP, Kendall GE, Sly PD, Holt PG: Association of IL12B promoter polymorphism with severity of atopic and non-atopic asthma in children. Lancet. 2002, 360: 455-9. 10.1016/S0140-6736(02)09676-9.
Article
PubMed
CAS
Google Scholar
Kastelein RA, Hunter CA, Cua DJ: Discovery and biology of IL-23 and IL-27: related but functionally distinct regulators of inflammation. Annu Rev Immunol. 2007, 25: 221-42. 10.1146/annurev.immunol.22.012703.104758.
Article
PubMed
CAS
Google Scholar
Filipe-Santos O, Bustamante J, Chapgier A, Vogt G, de Beaucoudrey L, Feinberg J, Jouanguy E, Boisson-Dupuis S, Fieschi C, Picard C, Casanova JL: Inborn errors of IL-12/23- and IFN-gamma-mediated immunity: molecular, cellular, and clinical features. Semin Immunol. 2006, 18: 347-361. 10.1016/j.smim.2006.07.010.
Article
PubMed
CAS
Google Scholar
Coombes JL, Siddiqui KR, Arancibia-Carcamo CV, Hall J, Sun CM, Belkaid Y, Powrie F: A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-{beta}- and retinoic acid-dependent mechanism. J Exp Med. 2007, 204: 1757-1764. 10.1084/jem.20070590.
Article
PubMed
CAS
PubMed Central
Google Scholar
Bilsborough TC, Norment GA, Viney JL: Mucosal CD8alpha+ DC, with a plasmacytoid phenotype, induce differentiation and support function of T cells with regulatory properties. Immunology. 2003, 108: 481-492. 10.1046/j.1365-2567.2003.01606.x.
Article
PubMed
CAS
PubMed Central
Google Scholar
Kalinski P, Hilkens CM, Wierenga EA, Kapsenberg ML: T-cell priming by type-1 and type-2 polarized dendritic cells: the concept of a third signal. Immunol Today. 1999, 20: 561-7. 10.1016/S0167-5699(99)01547-9.
Article
PubMed
CAS
Google Scholar
Di Cesare A, Di Meglio P, Nestle FO: The IL-23/Th17 axis in the immunopathogenesis of psoriasis. J Invest Dermatol. 2009, 129: 1339-50. 10.1038/jid.2009.59.
Article
PubMed
CAS
Google Scholar
Albanesi C, Scarponi C, Cavani A, Federici M, Nasorri F, Girolomoni G: Interleukin-17 is produced by both Th1 and Th2 lymphocytes, and modulates interferongamma-and interleukin-4-induced activation of human keratinocytes. J Invest Dermatol. 2000, 115: 81-7. 10.1046/j.1523-1747.2000.00041.x.
Article
PubMed
CAS
Google Scholar
Barczyk A, Pierzchala W, Sozanska E: Interleukin-17 in sputum correlates with airway hyperresponsiveness to methacholine. Respir Med. 2003, 97: 726-33. 10.1053/rmed.2003.1507.
Article
PubMed
CAS
Google Scholar
Kolls JK, Kanaly ST, Ramsay AJ: Interleukin-17: an emerging role in lung inflammation. Am J Respir Cell Mol Biol. 2003, 28: 9-11. 10.1165/rcmb.2002-0255PS.
Article
PubMed
CAS
Google Scholar
Louten J, Boniface K, de Waal Malefyt R: Development and function of TH17 cells in health and disease. J Allergy Clin Immunol. 2009, 123: 1004-11. 10.1016/j.jaci.2009.04.003.
Article
PubMed
CAS
Google Scholar
Huang SQ, Ninga ZX: Extraction of polysaccharide from Ganoderma lucidum and its immune enhancement activity. Intern J Biological Macromol. 2010, 47: 336-341. 10.1016/j.ijbiomac.2010.03.019.
Article
CAS
Google Scholar
Lai CY, Hung JT, Lin HH, Yu AL, Chen SH, Tsai YC, Shao LE, Yang WB, Yu J: Immuno-modulatory and adjuvant activities of a polysaccharide extract of Ganoderma lucidum in vivo and in vitro. Vaccine. 2010, 28: 4945-4954. 10.1016/j.vaccine.2010.05.037.
Article
PubMed
CAS
Google Scholar
Trinchieri G: Pro-inflammatory and immuno-regulatory functions of interleukin-12. Int Rev Immunol. 1998, 16: 365-96. 10.3109/08830189809043002.
Article
PubMed
CAS
Google Scholar
Linsley PS, Brady W, Urnes M, Grosmaire LS, Damle NK, Ledbetter JA: CTLA-4 is a second receptor for the B cell activation antigen B7. J Exp Med. 1991, 174: 561-9. 10.1084/jem.174.3.561.
Article
PubMed
CAS
Google Scholar
Linsley PS, Ledbetter JA: The role of the CD28 receptor during T cell responses to antigen. Annu Rev Immunol. 1993, 11: 191-212. 10.1146/annurev.iy.11.040193.001203.
Article
PubMed
CAS
Google Scholar
Pochard P, Hammad H, Ratajczak C, Charbonnier-Hatzfeld AS, Just N, Tonnel AB, Pestel J: Direct regulatory immune activity of lactic acid bacteria on Der p 1-pulsed dendritic cells from allergic patients. J Allergy Clin Immunol. 2005, 116: 198-204. 10.1016/j.jaci.2005.02.037.
Article
PubMed
CAS
Google Scholar
Sallusto F, Lanzavecchia A: Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulation factor plus interleukin 4 and down-regulated by tumor necrosis factor α. J Exp Med. 1994, 179: 1109-1118. 10.1084/jem.179.4.1109.
Article
PubMed
CAS
Google Scholar
Zhou LJ, Tedder TF: CD14+ blood monocytes can differentiate into functionally mature CD83+ dendritic cells. Proc Natl Acad Sci USA. 1996, 93: 2588-2592. 10.1073/pnas.93.6.2588.
Article
PubMed
CAS
PubMed Central
Google Scholar