Storek J, Gooley T, Witherspoon RP, Sullivan KM, Storb R: Infectious morbidity in long-term survivors of allogeneic marrow transplantation is associated with low CD4 T cell counts. Am J Hematol. 1997, 54: 131-138. 10.1002/(SICI)1096-8652(199702)54:2<131::AID-AJH6>3.0.CO;2-Y.
Article
PubMed
CAS
Google Scholar
Douek DC, Vescio RA, Betts MR, Brenchley JM, Hill BJ, Zhang L, Berenson JR, Collins RH, Koup RA: Assessment of thymic output in adults after haematopoietic stemcell transplantation and prediction of T-cell reconstitution. Lancet. 2000, 355: 1875-1881. 10.1016/S0140-6736(00)02293-5.
Article
PubMed
CAS
Google Scholar
van den Brink MRM, Alpdogan O, Boyd RL: Strategies to enhance T-cell reconstitution in immunocompromised patients. Nat Rev Immunol. 2004, 4: 856-867. 10.1038/nri1484.
Article
PubMed
CAS
Google Scholar
Heng TSP, Chidgey AP, Boyd RL: Getting back at nature: understanding thymic development and overcoming its atrophy. Curr Opin Pharmacol. 2010, 10: 425-433. 10.1016/j.coph.2010.04.006.
Article
PubMed
CAS
Google Scholar
Schmitt TM, Zuniga-Pflucker JC: T-cell development, doing it in a dish. Immunol Rev. 2006, 209: 95-102. 10.1111/j.0105-2896.2006.00353.x.
Article
PubMed
Google Scholar
Van Coppernolle S, Verstichel G, Timmermans F, Velghe I, Vermijlen D, De Smedt M, Leclercq G, Plum J, Taghon T, Vandekerckhove B: Functionally mature CD4 and CD8 TCRαβ cells are generated in OP9-DL1 cultures from human CD34+ hematopoietic cells. J Immunol. 2009, 183: 4859-4870. 10.4049/jimmunol.0900714.
Article
PubMed
CAS
Google Scholar
Awong G, Herer E, La Motte-Mohs R, Zuniga-Pflucker J: Human CD8 T cells generated in vitro from hematopoietic stem cells are functionally mature. BMC Immunol. 2011, 12: 22-10.1186/1471-2172-12-22.
Article
PubMed
CAS
PubMed Central
Google Scholar
Sioud M: Does our current understanding of immune tolerance, autoimmunity, and immunosuppressive mechanisms facilitate the design of efficient cancer vaccines?. Scand J Immunol. 2009, 70: 516-525. 10.1111/j.1365-3083.2009.02326.x.
Article
PubMed
CAS
Google Scholar
Stanevsky A, Shimoni A, Yerushalmi R, Nagler A: Cord blood stem cells for hematopoietic transplantation. Stem Cell Rev Rep. 2011, 7: 425-433. 10.1007/s12015-010-9183-9.
Article
Google Scholar
Patel E, Wang B, Lien L, Yang L-J, Moreb JS, Chang L-J: Diverse T cell differentiation potentials of human fetal thymus, fetal liver, cord blood and adult bone marrow CD34 cells on lentiviral Delta-like 1-modified mouse stromal cells. Immunology. 2009, 128: e497-e505. 10.1111/j.1365-2567.2008.03013.x.
Article
PubMed
PubMed Central
Google Scholar
De Smedt M, Leclercq G, Vandekerckhove B, Kerre T, Taghon T, Plum J: T-lymphoid differentiation potential measured in vitro is higher in CD34+CD38−/lo hematopoietic stem cells from umbilical cord blood than from bone marrow and is an intrinsic property of the cells. Haematologica. 2011, 96: 646-654. 10.3324/haematol.2010.036343.
Article
PubMed
CAS
PubMed Central
Google Scholar
Offner F, Kerre T, De Smedt M, Plum J: Bone marrow CD34+ cells generate fewer T cells in vitro with increasing age and following chemotherapy. Br J Haematol. 1999, 104: 801-808. 10.1046/j.1365-2141.1999.01265.x.
Article
PubMed
CAS
Google Scholar
De Smedt M, Hoebeke I, Plum J: Human bone marrow CD34+ progenitor cells mature to T cells on OP9-DL1 stromal cell line without thymus microenvironment. Blood Cells Mol Dis. 2004, 33: 227-232. 10.1016/j.bcmd.2004.08.007.
Article
PubMed
CAS
Google Scholar
Han S, Wang Y, Wang B, Patel E, Okada S, Yang L-J, Moreb J, Chang L-J: Ex vivo development, expansion and in vivo analysis of a novel lineage of dendritic cells from hematopoietic stem cells. J Immune Based Ther Vaccin. 2010, 8: 8-10.1186/1476-8518-8-8.
Article
CAS
Google Scholar
Ramiro AR, Trigueros C, Márquez C, San Millán JL, Toribio ML: Regulation of pre-T cell receptor (pT alpha-TCR beta) gene expression during human thymic development. J Exp Med. 1996, 184: 519-530. 10.1084/jem.184.2.519.
Article
PubMed
CAS
Google Scholar
Spits H: Development of αβ T cells in the human thymus. Nat Rev Immunol. 2002, 2: 760-772. 10.1038/nri913.
Article
PubMed
CAS
Google Scholar
Blom B, Verschuren MCM, Heemskerk MHM, Bakker AQ, van Gastel-Mol EJ, Wolvers-Tettero ILM, van Dongen JJM, Spits H: TCR gene rearrangements and expression of the pre-T cell receptor complex during human T-Cell differentiation. Blood. 1999, 93: 3033-3043.
PubMed
CAS
Google Scholar
Plum J, De Smedt M, Leclercq G: Exogenous IL-7 promotes the growth of CD3-CD4-CD8-CD44+CD25+/− precursor cells and blocks the differentiation pathway of TCR-alpha beta cells in fetal thymus organ culture. J Immunol. 1993, 150: 2706-2716.
PubMed
CAS
Google Scholar
Yasuda Y, Kaneko A, Nishijima I, Miyatake S, Arai K: Interleukin-7 inhibits pre-T-cell differentiation induced by the pre-T-cell receptor signal and the effect is mimicked by hGM-CSF in hGM-CSF receptor transgenic mice. Immunology. 2002, 106: 212-221. 10.1046/j.1365-2567.2002.01402.x.
Article
PubMed
CAS
PubMed Central
Google Scholar
Napolitano LA, Stoddart CA, Hanley MB, Wieder E, McCune JM: Effects of IL-7 on early human thymocyte progenitor cells in vitro and in SCID-hu Thy/Liv mice. J Immunol. 2003, 171: 645-654.
Article
PubMed
CAS
Google Scholar
El Kassar N, Lucas PJ, Klug DB, Zamisch M, Merchant M, Bare CV, Choudhury B, Sharrow SO, Richie E, Mackall CL: A dose effect of IL-7 on thymocyte development. Blood. 2004, 104: 1419-1427. 10.1182/blood-2004-01-0201.
Article
PubMed
CAS
Google Scholar
Yu Q, Erman B, Park JH, Feigenbaum L, Singer A: IL-7 receptor signals inhibit expression of transcription factors TCF-1, LEF-1, and RORgammat: impact on thymocyte development. J Exp Med. 2004, 200: 797-803. 10.1084/jem.20032183.
Article
PubMed
CAS
PubMed Central
Google Scholar
Brodeur J-F, Li S, Martins MS, Larose L, Dave VP: Critical and multiple roles for the CD3ε intracytoplasmic tail in double negative to double positive thymocyte differentiation. J Immunol. 2009, 182: 4844-4853. 10.4049/jimmunol.0803679.
Article
PubMed
CAS
Google Scholar
Jacobs H, Vandeputte D, Tolkamp L, De Vries E, Borst J, Berns A: CD3 components at the surface of pro-T cells can mediate pre-T cell development in vivo. Eur J Immunol. 1994, 24: 934-939. 10.1002/eji.1830240423.
Article
PubMed
CAS
Google Scholar
Shinkai Y, Alt FW: CD3ε-mediated signals rescue the development of CD4+CD8+ thymocytes in RAG-2−/− mice in the absence of TCR β chain expression. Int Immunol. 1994, 6: 995-1001. 10.1093/intimm/6.7.995.
Article
PubMed
CAS
Google Scholar
Fehling HJ, Krotkova A, Saint-Ruf C, von Boehmer H: Crucial role of the pre-T-cell receptor alpha gene in development of alpha beta but not gamma delta T cells. Nature. 1995, 375: 795-798. 10.1038/375795a0.
Article
PubMed
CAS
Google Scholar
Michie AM, Zúñiga-Pflücker JC: Regulation of thymocyte differentiation: pre-TCR signals and β-selection. Semin Immunol. 2002, 14: 311-323. 10.1016/S1044-5323(02)00064-7.
Article
PubMed
CAS
Google Scholar
Takeshita S TM, Yamagishi H: Excision products of the T cell receptor gene support a progressive rearrangement model of the alpha/delta locus. EMBO J. 1989, 8: 3261-3270.
PubMed
PubMed Central
Google Scholar
Ponchel F, Toomes C, Bransfield K, Leong F, Douglas S, Field S, Bell S, Combaret V, Puisieux A, Mighell A: Real-time PCR based on SYBR-Green I fluorescence: An alternative to the TaqMan assay for a relative quantification of gene rearrangements, gene amplifications and micro gene deletions. BMC Biotechnol. 2003, 3: 18-10.1186/1472-6750-3-18.
Article
PubMed
PubMed Central
Google Scholar
von Boehmer H: Unique features of the pre-T-cell receptor alpha-chain: not just a surrogate. Nat Rev Immunol. 2005, 5: 571-577. 10.1038/nri1636.
Article
PubMed
CAS
Google Scholar
Panigada M, Porcellini S, Barbier E, Hoeflinger S, Cazenave P-A, Gu H, Band H, von Boehmer H, Grassi F: Constitutive endocytosis and degradation of the pre-T cell receptor. J Exp Med. 2002, 195: 1585-1597. 10.1084/jem.20020047.
Article
PubMed
CAS
PubMed Central
Google Scholar
Yamasaki S, Ishikawa E, Sakuma M, Ogata K, Sakata-Sogawa K, Hiroshima M, Wiest DL, Tokunaga M, Saito T: Mechanistic basis of pre-T cell receptor-mediated autonomous signaling critical for thymocyte development. Nat Immunol. 2006, 7: 67-75.
Article
PubMed
CAS
Google Scholar
Fehling HJ, Iritani BM, Krotkova A, Forbush KA, Laplace C, Perlmutter RM, von Boehmer H: Restoration of thymopoiesis in pT alpha−/− mice by anti-CD3epsilon antibody treatment or with transgenes encoding activated Lck or tailless pT alpha. Immunity. 1997, 6: 703-714. 10.1016/S1074-7613(00)80446-X.
Article
PubMed
CAS
Google Scholar
Schmitt TM, Zuniga-Pflucker JC: Induction of T cell development from hematopoietic progenitor cells by delta-like-1 in vitro. Immunity. 2002, 17: 749-756. 10.1016/S1074-7613(02)00474-0.
Article
PubMed
CAS
Google Scholar
La Motte-Mohs R, Herer E, Zuniga-Pflucker J: Induction of T-cell development from human cord blood hematopoietic stem cells by Delta-like 1 in vitro. Blood. 2005, 105: 1431-1439. 10.1182/blood-2004-04-1293.
Article
PubMed
CAS
Google Scholar
Alsheikhly A-R, Zweiri J, Walmesley AJ, Watson AJM, Christmas SE: Both soluble and membrane-bound forms of Flt3 ligand enhance tumor immunity following “suicide” gene therapy in a murine colon carcinoma model. Cancer Immunol Immunother. 2004, 53: 946-954.
PubMed
CAS
Google Scholar
Opdenakker G, Rudd P, Wormald M, Dwek R, Van Damme J: Cells regulate the activities of cytokines by glycosylation. FASEB J. 1995, 9: 453-457.
PubMed
CAS
Google Scholar
Levy Y, Lacabaratz C, Weiss L, Viard J-P, Goujard C, Lelièvre J-D, Boué F, Molina J-M, Rouzioux C, Avettand-Fénoêl V: Enhanced T cell recovery in HIV-1–infected adults through IL-7 treatment. J Clin Invest. 2009, 119: 997-1007.
PubMed
CAS
PubMed Central
Google Scholar
García-Peydró M, de Yébenes VG, Toribio ML: Notch1 and IL-7 receptor interplay maintains proliferation of human thymic progenitors while suppressing non-T cell fates. J Immunol. 2006, 177: 3711-3720.
Article
PubMed
Google Scholar
Xiong J, Armato MA, Yankee TM: Immature single-positive CD8+ thymocytes represent the transition from Notch-dependent to Notch-independent T-cell development. Int Immunol. 2011, 23: 55-64. 10.1093/intimm/dxq457.
Article
PubMed
CAS
PubMed Central
Google Scholar
von Freeden-Jeffry U, Vieira P, Lucian LA, McNeil T, Burdach SE, Murray R: Lymphopenia in interleukin IL-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine. J Exp Med. 1995, 181: 1519-1526. 10.1084/jem.181.4.1519.
Article
PubMed
CAS
Google Scholar
Pellegrini M, Calzascia T, Elford AR, Shahinian A, Lin AE, Dissanayake D, Dhanji S, Nguyen LT, Gronski MA, Morre M: Adjuvant IL-7 antagonizes multiple cellular and molecular inhibitory networks to enhance immunotherapies. Nat Med. 2009, 15: 528-536. 10.1038/nm.1953.
Article
PubMed
CAS
Google Scholar
Plum J, De Smedt M, Leclercq G, Verhasselt B, Vandekerckhove B: Interleukin-7 is a critical growth factor in early human T-cell development. Blood. 1996, 88: 4239-4245.
PubMed
CAS
Google Scholar
Godfrey DI, Kennedy J, Mombaerts P, Tonegawa S, Zlotnik A: Onset of TCR-beta gene rearrangement and role of TCR-beta expression during CD3-CD4-CD8- thymocyte differentiation. J Immunol. 1994, 152: 4783-4792.
PubMed
CAS
Google Scholar
Maki K, Sunaga S, Komagata Y, Kodaira Y, Mabuchi A, Karasuyama H, Yokomuro K, Miyazaki JI, Ikuta K: Interleukin 7 receptor-deficient mice lack gammadelta T cells. Proc Natl Acad Sci U S A. 1996, 93: 7172-7177. 10.1073/pnas.93.14.7172.
Article
PubMed
CAS
PubMed Central
Google Scholar
Moore T, von Freeden-Jeffry U, Murray R, Zlotnik A: Inhibition of gamma delta T cell development and early thymocyte maturation in IL-7 −/− mice. J Immunol. 1996, 157: 2366-2373.
PubMed
CAS
Google Scholar
Marino JH, Tan C, Taylor AA, Bentley C, Van De Wiele CJ, Ranne R, Paliotta M, Broughan TA, Teague TK: Differential IL-7 responses in developing human thymocytes. Hum Immunol. 2010, 71: 329-333. 10.1016/j.humimm.2010.01.009.
Article
PubMed
CAS
PubMed Central
Google Scholar
Suda T, Zlotnik A: In vitro induction of CD8 expression on thymic pre-T cells. I. Transforming growth factor-beta and tumor necrosis factor-alpha induce CD8 expression on CD8- thymic subsets including the CD25+CD3-CD4-CD8- pre-T cell subset. J Immunol. 1992, 148: 1737-1745.
PubMed
CAS
Google Scholar
Germain RN: T-cell development and the CD4-CD8 lineage decision. Nat Rev Immunol. 2002, 2: 309-322. 10.1038/nri798.
Article
PubMed
CAS
Google Scholar
Yarilin AA, Belyakov IM: Cytokines in the thymus: production and biological effects. Curr Med Chem. 2004, 11: 447-464. 10.2174/0929867043455972.
Article
PubMed
CAS
Google Scholar
Takahama Y: Journey through the thymus: stromal guides for T-cell development and selection. Nat Rev Immunol. 2006, 6: 127-135. 10.1038/nri1781.
Article
PubMed
CAS
Google Scholar
Carpenter AC, Bosselut R: Decision checkpoints in the thymus. Nat Immunol. 2010, 11: 666-673. 10.1038/ni.1887.
Article
PubMed
CAS
PubMed Central
Google Scholar
Li W, Kim MG, Gourley TS, McCarthy BP, Sant'Angelo DB, Chang CH: An alternate pathway for CD4 T cell development: thymocyte-expressed MHC class II selects a distinct T cell population. Immunity. 2005, 23: 375-386. 10.1016/j.immuni.2005.09.002.
Article
PubMed
CAS
Google Scholar
Bell E: T-cell development: thymocyte-selected CD4+ T cells. Nat Rev Immunol. 2007, 7: 748-749.
Article
CAS
Google Scholar
Saito Y, Kametani Y, Hozumi K, Mochida N, Ando K, Ito M, Nomura T, Tokuda Y, Makuuchi H, Tajima T: The in vivo development of human T cells from CD34+ cells in the murine thymic environment. Int Immunol. 2002, 14: 1113-1124. 10.1093/intimm/dxf087.
Article
PubMed
CAS
Google Scholar
Yahata T, Ando K, Nakamura Y, Ueyama Y, Shimamura K, Tamaoki N, Kato S, Hotta T: Functional human T lymphocyte development from cord blood CD34+ cells in nonobese diabetic/Shi-scid, IL-2 receptor gamma null mice. J Immunol. 2002, 169: 204-209.
Article
PubMed
CAS
Google Scholar
Hiramatsu H, Nishikomori R, Heike T, Ito M, Kobayashi K, Katamura K, Nakahata T: Complete reconstitution of human lymphocytes from cord blood CD34+ cells using the NOD/SCID/gammaC null mice model. Blood. 2003, 102: 873-880. 10.1182/blood-2002-09-2755.
Article
PubMed
CAS
Google Scholar
Traggiai E, Chicha L, Mazzucchelli L, Bronz L, Piffaretti JC, Lanzavecchia A, Manz MG: Development of a human adaptive immune system in cord blood cell-transplanted mice. Science. 2004, 304: 104-107. 10.1126/science.1093933.
Article
PubMed
CAS
Google Scholar