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  1. Immune response is prevalently related with major depressive disorder (MDD) pathophysiology. However, the study on the relationship between immune-related genes (IRGs) and immune infiltrates of MDD remains sca...

    Authors: Linna Ning, Zhou Yang, Jie Chen, Zhaopeng Hu, Wenrui Jiang, Lixia Guo, Yan Xu, Huiming Li, Fanghua Xu and Dandong Deng
    Citation: BMC Immunology 2022 23:6
    Content type: Research Published on:

  2. Determining T cell responses to naturally processed and presented antigens is a critical immune correlate to determine efficacy of an investigational immunotherapeutic in clinical trials. In most cases, minima...

    Authors: Jay Friedman, Sreenivasulu Gunti, Maxwell Lee, Ke Bai, Christian Hinrichs and Clint T. Allen
    Citation: BMC Immunology 2022 23:5
    Content type: Research Published on:

  3. Adult-onset Still's disease (AOSD) is a systemic inflammatory disease of unknown etiology, lacking specific diagnosis and disease activity evaluation indicators. This study will analyze the activity and clinic...

    Authors: Zhiye Xu, Linyu Geng, LiLi Guo, Hongyan Song, Jie Pan, Han Shen and Sen Wang
    Citation: BMC Immunology 2022 23:4
    Content type: Research Published on:

  4. This study was aimed to identify the biomarkers for diagnosis and reveal the immune microenvironment changes in ankylosing spondylitis (AS).

    Authors: Tuo Liang, Jiarui Chen, GuoYong Xu, Zide Zhang, Jiang Xue, Haopeng Zeng, Jie Jiang, Tianyou Chen, Zhaojie Qin, Hao Li, Zhen Ye, Yunfeng Nie, Xinli Zhan and Chong Liu
    Citation: BMC Immunology 2022 23:3
    Content type: Research Published on:

  5. Despite high rate of vaccination coverage with 2-doses of measles containing vaccine among Iranian children, outbreaks of measles occurred among different age groups and fully vaccinated subjects. Although the...

    Authors: Hana Saffar, Sayed Jaber Mousavi, Hiva Saffar, Mohammad-Reza Parsaei, Gholam-Reza Ghorbani and Mohammad Jafar Saffar
    Citation: BMC Immunology 2022 23:2
    Content type: Research Published on:

  6. Formin-binding protein 1/17 (FNBP1/FBP17), as a membrane-bound protein, is wildly expressed in eukaryotic cells and performs a critical role in tumor tumorigenesis and progression. However, the relationship betwe...

    Authors: Zixuan Wang, Zixin Tian, Xi Song and Jun Zhang
    Citation: BMC Immunology 2022 23:1
    Content type: Research Published on:

  7. The chemokine CXCL1, known as growth-related oncogene α (GRO-α), is a potent chemoattractant and regulator of neutrophils. The purpose of our study was to evaluate the regulatory response of CXCL1 in the serum...

    Authors: Yanli Zeng, Qiaoduan Lin, Liang Yu, Xuelian Wang, Yiqiang Lin, Yan Zhang, Shuidi Yan, Xinxin Lu, Yijing Li, Weibin Li and Yun Xiao
    Citation: BMC Immunology 2021 22:82
    Content type: Research Published on:

  8. ABP501 is a biosimilar to Reference Adalimumab (HUMIRA®) produced by AMGEN. Adalimumab (ADA) has a marketing authorization for Crohn's disease, ulcerative colitis and other inflammatory or autoimmune diseases....

    Authors: Fabien Francois, Loubna Naimi, Xavier Roblin, Anne-Emmanuelle Berger and Stephane Paul
    Citation: BMC Immunology 2021 22:81
    Content type: Research article Published on:

  9. Appropriate reference ranges of T lymphocyte subsets are essential for immune status evaluation of patients with immunological diseases. We aim to establish the age- and sex-related reference intervals of T ly...

    Authors: Bin Wei, Ying Guo, Liangjun Zhang, Huixiu Zhong, Qiang Miao, Lin Yan, Yangjuan Bai, Weihua Feng, Weiping Liu, Qian Niu and Yi Li
    Citation: BMC Immunology 2021 22:80
    Content type: Research Published on:

  10. Interleukin (IL)-15 is a proinflammatory T-cell growth factor overexpressed in several autoimmune diseases such as rheumatoid arthritis. Our initial strategy to neutralize the increased levels of IL-15 consist...

    Authors: Yunier Rodríguez-Álvarez, Lino Gerardo Batista-Roche, Alexey Llopiz-Arzuaga, Pedro Puente-Pérez, Rafael Martínez-Castillo, Jorge Castro-Velazco and Alicia Santos-Savio
    Citation: BMC Immunology 2021 22:79
    Content type: Research Published on:

  11. Phosphoinositide-3-kinase-delta (PI3Kδ) inhibition is a promising therapeutic approach for inflammatory conditions due to its role in leucocyte proliferation, migration and activation. However, the effect of P...

    Authors: Sorif Uddin, Augustin Amour, David J. Lewis, Chris D. Edwards, Matthew G. Williamson, Simon Hall, Lisa A. Lione and Edith M. Hessel
    Citation: BMC Immunology 2021 22:78
    Content type: Research Published on:

  12. Inflammatory arthritis including rheumatoid arthritis (RA) and spondyloarthritis (SpA) is characterized by inflammation and destruction of the joints. Approximately one third of patients do not respond to firs...

    Authors: A. L. Hansen, L. S. J. Rahbek, A. S. Sørensen, M. P. Hundahl, S. Lomholt, C. K. Holm and Tue W. Kragstrup
    Citation: BMC Immunology 2021 22:77
    Content type: Research Published on:

  13. To identify lymphocyte and CD4 + T cell subset characteristics, particularly regulatory T cells (Tregs), in active rheumatoid arthritis (RA) patients with coronary artery disease (CAD).

    Authors: Yanyan Wang, Rui Su, Baochen Li, Qiaoling Guo, Fangyuan Hu, Xiaopu Yu, Mingxia Ma, Lizhi Wang, Chong Gao, Xiaofeng Li and Caihong Wang
    Citation: BMC Immunology 2021 22:76
    Content type: Research Published on:

  15. Mitochondrial transcription factor A (TFAM) is associated with a number of neurodegenerative diseases and also with asthma. TFAM deficiency-induced mitochondrial DNA stress primes the antiviral innate immune r...

    Authors: Jinsong Luo, Hong Liu, Daniel K. Jun Li, Bin Song and Yi Zhang
    Citation: BMC Immunology 2021 22:74
    Content type: Research Published on:

  16. Immunoglobulin A nephropathy (IgAN) is one of the most common primary glomerulonephritis and a serious health concern worldwide; though still the underlying molecular mechanisms of IgAN are yet to be known and...

    Authors: Alieh Gholaminejad, Amir Roointan and Yousof Gheisari
    Citation: BMC Immunology 2021 22:73
    Content type: Research Published on:

  17. Macrophages are involved in the pathophysiology of many diseases as critical cells of the innate immune system. Pyroptosis is a form of macrophage death that induces cytokinesis of phagocytic substances in the...

    Authors: Shan-Shan Huang, Dong-Yang Guo, Bing-Bing Jia, Guo-Long Cai, Jing Yan, Yan Lu and Zhou-Xin Yang
    Citation: BMC Immunology 2021 22:72
    Content type: Research Published on:

  18. The natural antibody responses to B-cell epitopes from dengue structural proteins were assessed using immune sera from people having well-defined past dengue infections with one of the four serotypes.

    Authors: Mahesha N. Nadugala, Chandima Jeewandara, Ramesh S. Jadi, Gathsaurie N. Malavige, Aravinda M. de Silva, Prasad H. Premaratne and Charitha L. Goonasekara
    Citation: BMC Immunology 2021 22:71
    Content type: Research Published on:

  19. Hemodialysis (HD) patients have an increased risk of acquiring infections due to many health care contacts and may, in addition, have a suboptimal response to vaccination and a high mortality from Covid-19 inf...

    Authors: Jan Melin, Maria K. Svensson, Bo Albinsson, Ola Winqvist and Karlis Pauksens
    Citation: BMC Immunology 2021 22:70
    Content type: Research article Published on:

  20. Previous studies have indicated that the programmed death molecule 1 (PD-1) signaling pathway may play a key role in rheumatoid arthritis (RA). However, the pathogenesis of rheumatoid arthritis-related interst...

    Authors: Li Xu, Lichun Jiang, Liuyan Nie, Songzhao Zhang, Lei Liu, Yan Du and Jing Xue
    Citation: BMC Immunology 2021 22:69
    Content type: Research Published on:

  21. The necessity of the tetanus-reduced dose diphtheria-acellular pertussis (Tdap) vaccine in adolescence and adults has been emphasized since the resurgence of small-scale pertussis in Korea and worldwide due to...

    Authors: Kyu Ri Kang, Dong Ho Huh, Ji Ahn Kim and Jin Han Kang
    Citation: BMC Immunology 2021 22:68
    Content type: Research article Published on:

  22. Toll-like receptors (TLRs) play central roles in the initiation of innate immune response, and also control adaptive immunity activation. Thus, the aim of the study was to investigate the regulation of TLR act...

    Authors: Junli Xu, Rongya Guo, Jing Jia, Yun He and Shuixiang He
    Citation: BMC Immunology 2021 22:67
    Content type: Research Published on:

  23. Currently, research on the quantitative distribution of ABO antigens in different organs and tissues remains limited. We aimed to examine the individual characteristics of blood group glycoprotein A and B anti...

    Authors: Xianding Wang, Fan Zhang, Yamei Jiang, Zilin Xu, Xiaobing Feng, Linde Li, Yu Fan, Turun Song, Yunying Shi, Zhongli Huang and Tao Lin
    Citation: BMC Immunology 2021 22:66
    Content type: Research Published on:

  24. Adoptive transfer of T cells genetically engineered with a T cell receptor (TCR) is a promising cancer treatment modality that requires the identification of TCRs with good characteristics. Most T cell cloning...

    Authors: Lei Chen, Lianhua Dong, Yipeng Ma, Juntao Wang, Dongjuan Qiao, Geng Tian and Mingjun Wang
    Citation: BMC Immunology 2021 22:65
    Content type: Research Published on:

  26. Immuno-epidemiologists are often faced with multivariate outcomes, measured repeatedly over time. Such data are characterised by complex inter- and intra-outcome relationships which must be accounted for durin...

    Authors: Lawrence Lubyayi, Patrice A. Mawa, Stephen Cose, Alison M. Elliott, Jonathan Levin and Emily L. Webb
    Citation: BMC Immunology 2021 22:63
    Content type: Methodology article Published on:

  27. Mendelian Susceptibility to Mycobacterial Disease (MSMD) is a primary immunodeficiency (PID) characterised by a predisposition to infection by weakly-pathogenic mycobacteria. In countries with a high prevalenc...

    Authors: Ansia van Coller, Brigitte Glanzmann, Helena Cornelissen, Marlo Möller, Craig Kinnear, Monika Esser and Richard Glashoff
    Citation: BMC Immunology 2021 22:62
    Content type: Research Published on:

  28. Although the onset of inflammatory cascades may profoundly influence the nature of antibody responses, the interplay between inflammatory and humoral (antibody) immune markers remains unclear. Thus, we explore...

    Authors: Aida Santaolalla, Sam Sollie, Ali Rislan, Debra H. Josephs, Niklas Hammar, Goran Walldius, Hans Garmo, Sophia N. Karagiannis and Mieke Van Hemelrijck
    Citation: BMC Immunology 2021 22:61
    Content type: Research article Published on:

  29. Immune checkpoint inhibitors have aroused great expectation of tumor eradication. However, the effect of anti-PD-L1 treatment for cervical cancer is unsatisfactory and the underlying antagonist to anti-PD-L1 e...

    Authors: Fengying Xu, Fengying Zhang, Qian Wang, Ying Xu, Shuifang Xu, Caihong Zhang and Lihua Wang
    Citation: BMC Immunology 2021 22:60
    Content type: Research Published on:

  30. Innate lymphoid cells (ILC) are lymphoid lineage innate immune cells that do not mount antigen-specific responses due to their lack of B and T-cell receptors. ILCs are predominantly found at mucosal surfaces, ...

    Authors: Rose Nabatanzi, Lois Bayigga, Stephen Cose, Glenda Canderan, Sarah Rowland Jones, Moses Joloba and Damalie Nakanjako
    Citation: BMC Immunology 2021 22:59
    Content type: Research Published on:

  31. Intratumoral regulatory T cells (Treg) in colon cancer are a heterogeneous cell population, with potential impact on patient outcome. Generally, a high Treg infiltration has been correlated to a worse patient ...

    Authors: Louis Szeponik, Filip Ahlmanner, Patrik Sundström, William Rodin, Bengt Gustavsson, Elinor Bexe Lindskog, Yvonne Wettergren and Marianne Quiding-Järbrink
    Citation: BMC Immunology 2021 22:58
    Content type: Research Published on:

  32. Circadian rhythm is an important player for reproduction. Rev-erbα, a significant clock gene, is involved in regulating cell differentiation, inflammation and metabolism. Macrophage polarization plays crucial ...

    Authors: Liyuan Cui, Feng Xu, Songcun Wang, Xinyi Li, Haiyan Lin, Yan Ding and Meirong Du
    Citation: BMC Immunology 2021 22:57
    Content type: Research Published on:

  33. Invariant chain (CD74, Ii) is a multifunctional protein expressed in antigen presenting cells. It assists the ER exit of various cargos and serves as a receptor for the macrophage migration inhibitory factor. ...

    Authors: Maryse Cloutier, Jean-Simon Fortin and Jacques Thibodeau
    Citation: BMC Immunology 2021 22:56
    Content type: Research article Published on:

  34. Cancer immunotherapy has gained increasing popularity as a novel approach to treat cancer. A member of the B7 family, V-domain immunoglobulin suppressor of T-cell activation (VISTA) is a novel immune checkpoin...

    Authors: Ting-ting Li, Jing-wei Jiang, Chen-xin Qie, Chun-xiao Xuan, Xin-lei Hu, Wan-mei Liu, Wen-ting Chen and Jun Liu
    Citation: BMC Immunology 2021 22:55
    Content type: Research article Published on:

  35. Both hepatitis C virus (HCV) infection and adiponectin are critically involved in metabolism. The reversal and associations of altering adiponectin levels after sustained virological responses (SVRs) following...

    Authors: Ming-Ling Chang, Jing-Hong Hu, Li-Heng Pao, Ming-Shyan Lin, Chia-Jung Kuo, Shiang-Chi Chen, Chun-Ming Fan, Ming-Yu Chang and Rong-Nan Chien
    Citation: BMC Immunology 2021 22:54
    Content type: Research article Published on:

  37. Current research suggests that the glial scar surrounding penetrating brain injuries is instrumental in preserving the surrounding uninjured tissue by limiting the inflammatory response to the injury site. We ...

    Authors: Kazadi Nadine Mutoji, Mingxia Sun, Amanda Nash, Sudan Puri, Vincent Hascall and Vivien J. Coulson-Thomas
    Citation: BMC Immunology 2021 22:52
    Content type: Research article Published on:

  38. Neutrophils induce the synthesis and release of angiopoietin 1 (Ang1), a cytosolic growth factor involved in angiogenesis and capable of inducing several pro-inflammatory activities in neutrophils. Neutrophils...

    Authors: Elcha Charles, Benjamin L. Dumont, Steven Bonneau, Paul-Eduard Neagoe, Louis Villeneuve, Agnès Räkel, Michel White and Martin G. Sirois
    Citation: BMC Immunology 2021 22:51
    Content type: Research Published on:

  39. Good's syndrome (GS) is a rare secondary immunodeficiency disease presenting as thymoma and hypogammaglobulinemia. Due to its rarity, the diagnosis of GS is often missed.

    Authors: Jinyao Ni, Junwu Zhang, Yanxia Chen, Weizhong Wang and Jinlin Liu
    Citation: BMC Immunology 2021 22:50
    Content type: Research Published on:

  40. Targeted immunotherapy is mostly associated with cancer treatment wherein designed molecules engage signaling pathways and mutant proteins critical to the survival of the cell. One of several genetic approache...

    Authors: Daniel A. Achinko, Anton Dormer, Mahesh Narayanan and Elton F. Norman
    Citation: BMC Immunology 2021 22:49
    Content type: Research Published on:

  41. The presence of the human leukocyte antigen HLA-B*57:01 is associated with the development of a hypersensitivity reaction to abacavir (ABC). Limited data exist on HLA-B*57:01 prevalence in individuals with HIV...

    Authors: Malewe Kolou, Armel Poda, Zelica Diallo, Esther Konou, Tatiana Dokpomiwa, Jacques Zoungrana, Mounerou Salou, Lionèle Mba-Tchounga, André Bigot, Abdoul-Salam Ouedraogo, Marielle Bouyout-Akoutet, Didier K. Ekouevi and Serge P. Eholie
    Citation: BMC Immunology 2021 22:48
    Content type: Research Published on:

  43. Acute graft-versus-host disease (aGVHD) is one of the most common causes of morbidity for patients undergoing allogeneic stem cell transplantation. There is preliminary evidence that activated Group 2 innate l...

    Authors: Anand Srinivasan, Sandra Bajana, Aneta Pankow, Carrie Yuen, Rikin K. Shah and Xiao-Hong Sun
    Citation: BMC Immunology 2021 22:46
    Content type: Research Published on:

  45. Transforming growth factor beta (TGF-β) is a typical immuno-inhibitory cytokine and highly secreted by lung cancer cells. It was supposed that its immunosuppressive effects to NK cell might be related with the...

    Authors: Young Shin Lee, Hojung Choi, Hae-Ryung Cho, Woo-Chang Son, You-Soo Park, Chi-Dug Kang and Jaeho Bae
    Citation: BMC Immunology 2021 22:44
    Content type: Research Published on:

  46. The successful ex vivo expansion of T-cells in great numbers is the cornerstone of adoptive cell therapy. We aimed to achieve the most optimal T-cell expansion condition by comparing the expansion of T-cells a...

    Authors: Sasan Ghaffari, Monireh Torabi-Rahvar, Sajjad Aghayan, Zahra Jabbarpour, Kobra Moradzadeh, Azadeh Omidkhoda and Naser Ahmadbeigi
    Citation: BMC Immunology 2021 22:43
    Content type: Research Published on:

  47. Obesity is correlated with worse drug responses and high disease activity in patients with rheumatoid arthritis (RA). Interleukin (IL)-35 is a novel anti-inflammatory cytokine that mainly produced by regulator...

    Authors: Yuxuan Li, Yang Jie, Xiaofei Wang and Jing Lu
    Citation: BMC Immunology 2021 22:42
    Content type: Research article Published on:

  48. There is a global focus on illness diagnosis in smear-negative and latent tuberculosis infectious populations (SN-TB and LTBI). CD27 has been suggested to play a direct role in active TB. Little is known about...

    Authors: Feifan Xu, Haiyun Zhang, Xiaoyan Si, Junlin Chen, Yuhao Chen, Xiaopeng Cui and Yongwei Qin
    Citation: BMC Immunology 2021 22:41
    Content type: Research article Published on:

  50. Health care workers (HCWs) are at risk for occupationally acquired Mycobacterium tuberculosis infection and tuberculosis (TB) disease due to repeated exposure to workplace tubercle bacilli. To determine whether c...

    Authors: Cui-lin Shi, Jian-ping Zhang, Ping Xu, Jin Li, Jie Shen, Mei-ying Wu, Zhi-jian Ye, Xin Yu, Hua-feng Song, Hui Chen, Jun-chi Xu, Yu Pang and Jian-an Huang
    Citation: BMC Immunology 2021 22:39
    Content type: Research Published on:

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BMC Immunology

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