Skip to main content

Articles

Page 11 of 24

  1. Regulatory CD4 T cells (Tregs) are critical in maintaining the homeostasis of the immune system. Quantitative or phenotypic alterations and functional impairment of Tregs have been associated with the developm...

    Authors: Raquel Matavele Chissumba, Suse Dayse Silva-Barbosa, Ângelo Augusto, Cremildo Maueia, Nédio Mabunda, Eduardo Samo Gudo Jr, Nilesh Bhatt, Ilesh Jani and Wilson Savino
    Citation: BMC Immunology 2015 16:52
    Content type: Research article Published on:

  2. Endometriosis is defined as the presence of endometrial glands and stroma at ectopic locations. Although the prevalence of endometriosis is as high as 35 %–50 %, its pathogenesis remains controversial. An incr...

    Authors: Mary Lourdes Montenegro, Rui Alberto Ferriani and Per H. Basse
    Citation: BMC Immunology 2015 16:51
    Content type: Research article Published on:

  3. As a result of successful PMTCT programs, children born from HIV-infected mothers are now effectively protected from contracting the infection. However, it is not well known whether in utero exposure to the virus...

    Authors: Herbert Longwe, Kamija S. Phiri, Nyanyiwe M. Mbeye, Thandile Gondwe, Kondwani C. Jambo and Wilson L. Mandala
    Citation: BMC Immunology 2015 16:50
    Content type: Research article Published on:

  4. The changes in T-cell morphology during immunological synapse (IS) formation are essential for T-cell activation. Previous researches have shown that T cell changed from spherical to elongated and/or flattened...

    Authors: Wei Lin, Yuanzhen Suo, Yuting Deng, Zhichao Fan, Yijie Zheng, Xunbin Wei and Yiwei Chu
    Citation: BMC Immunology 2015 16:49
    Content type: Research article Published on:

  5. High quality genetic material is an essential pre-requisite when analyzing gene expression using microarray technology. Peripheral blood mononuclear cells (PBMC) are frequently used for genomic analyses, but s...

    Authors: Christopher P. Corkum, Danielle P. Ings, Christopher Burgess, Sylwia Karwowska, Werner Kroll and Tomasz I. Michalak
    Citation: BMC Immunology 2015 16:48
    Content type: Methodology Published on:

  6. Macrophage migration inhibitory factor (MIF) is a cytokine that shares many activities with other pro-inflammatory cytokines in primary glomerulonephritis (GN). This study assesses the influence of immunosuppr...

    Authors: Rafał Zwiech
    Citation: BMC Immunology 2015 16:47
    Content type: Research article Published on:

  7. Comparative analysis of genome-wide expression profiles are increasingly being used to study virus-specific host interactions. In order to gain mechanistic insights, gene expression profiles can be combined wi...

    Authors: Juilee Thakar, Boris M. Hartmann, Nada Marjanovic, Stuart C. Sealfon and Steven H. Kleinstein
    Citation: BMC Immunology 2015 16:46
    Content type: Research article Published on:

  8. IFNγ-producing CD4+CD25+Foxp3+CD127- Treg represent the first line of Treg during an immune response. In the present study we determined whether IFNγ+ Treg in-vivo and in-vitro are Helios-positive representing...

    Authors: Volker Daniel, Karina Trojan, Martina Adamek and Gerhard Opelz
    Citation: BMC Immunology 2015 16:45
    Content type: Research article Published on:

  9. Cystic echinococcosis, caused by infection with Echinococcus granulosus, is one of the most widespread zoonotic helminth diseases. Modulation of host responses is an important strategy used by helminth parasites ...

    Authors: Ying Wang, Hejun Zhou, Yujuan Shen, Yanjuan Wang, Weiping Wu, Haipeng Liu, Zhongying Yuan, Yuxin Xu, Yuan Hu and Jianping Cao
    Citation: BMC Immunology 2015 16:44
    Content type: Research article Published on:

  10. Systemic immune activation (inflammation) and immunosenescence develop in some people with advancing age. This process, known as “inflamm-aging,” is associated with physical frailty and sarcopenia. Meanwhile, ...

    Authors: Mark A. Wallet, Thomas W. Buford, Anna-Maria Joseph, Madhuri Sankuratri, Christiaan Leeuwenburgh, Marco Pahor, Todd Manini, John W. Sleasman and Maureen M. Goodenow
    Citation: BMC Immunology 2015 16:43
    Content type: Research article Published on:

  11. TLR8 assists in antiviral approach by producing Type 1 INF via MyD88 dependent IRF7 pathway. However, over expression of INFα/β molecule poses threat by developing tolerance in chronic infection cases and enhanci...

    Authors: Anurag Adhikari, Birendra Prasad Gupta, Krishna Das Manandhar, Shravan Kumar Mishra, Hari Krishna Saiju, Rajendra Maan Shrestha, Nawneet Mishra and Shishir Sharma
    Citation: BMC Immunology 2015 16:42
    Content type: Research article Published on:

  12. Pepsin-trypsin resistant gliadin (PT-gliadin) promotes intestinal tissue inflammation and increases paracellular permeability of immunogenic gliadin peptides into the lamina propria. This leads to the complica...

    Authors: Naiyana Gujral, Ju Won Suh and Hoon H. Sunwoo
    Citation: BMC Immunology 2015 16:41
    Content type: Research article Published on:

  13. Pertussis (whooping cough) remains a public health problem despite extensive vaccination strategies. Better understanding of the host-pathogen interaction and the detailed B. pertussis (Bp) target recognition pat...

    Authors: Davide Valentini, Giovanni Ferrara, Reza Advani, Hans O Hallander and Markus J Maeurer
    Citation: BMC Immunology 2015 16:40
    Content type: Methodology article Published on:

  14. Programmed cell death 1 (PD-1) is a key cell-surface receptor of CD28 superfamily that triggers inhibitory pathways to attenuate T-cell responses and promote T-cell tolerance. As a crucial role in tumor immuni...

    Authors: Kailin Xing, Bingxin Gu, Ping Zhang and Xianghua Wu
    Citation: BMC Immunology 2015 16:39
    Content type: Research article Published on:

  15. Tuberculosis (TB) remains a serious human health problem that affects millions of people in the world. Understanding the biology of Mycobacterium tuberculosis (Mtb) is essential for tackling this devastating dise...

    Authors: Patricia Espinosa-Cueto, Marina Escalera-Zamudio, Alejandro Magallanes-Puebla, Luz María López-Marín, Erika Segura-Salinas and Raúl Mancilla
    Citation: BMC Immunology 2015 16:38
    Content type: Research article Published on:

  16. Phenotype of chronic rhinosinusitis (CRS) may be an important determining factor of the efficacy of anti-inflammatory treatments. Although both glucocorticoids and macrolide antibiotics have been recommended f...

    Authors: Ming Zeng, Zhi-Yong Li, Jin Ma, Ping-Ping Cao, Heng Wang, Yong-Hua Cui and Zheng Liu
    Citation: BMC Immunology 2015 16:37
    Content type: Research article Published on:

  17. Lung inflammation is a major consequence of the systemic inflammatory response caused by severe sepsis. Increased migration of γδ T lymphocytes into the lungs has been previously demonstrated during experiment...

    Authors: Maria Fernanda de Souza Costa, Catarina Bastos Trigo de Negreiros, Victor Ugarte Bornstein, Richard Hemmi Valente, José Mengel, Maria das Graças Henriques, Claudia Farias Benjamim and Carmen Penido
    Citation: BMC Immunology 2015 16:36
    Content type: Research article Published on:

  18. Abnormal immune function is often an underlying component of illness pathophysiology and symptom presentation. Functional and phenotypic immune-related alterations may play a role in the obscure pathomechanism...

    Authors: Sharni Lee Hardcastle, Ekua Weba Brenu, Samantha Johnston, Thao Nguyen, Teilah Huth, Naomi Wong, Sandra Ramos, Donald Staines and Sonya Marshall-Gradisnik
    Citation: BMC Immunology 2015 16:35
    Content type: Research article Published on:

  20. Technical feasibility of RNA quantification by real time RT-PCR has led to enormous utilization of this method. However, real time PCR results need to be normalized due to the high sensitivity of the method an...

    Authors: Mehdi Emam, Kathleen Thompson-Crispi and Bonnie Mallard
    Citation: BMC Immunology 2015 16:33
    Content type: Research article Published on:

  22. The concept of the immunogenicity of an antigen is frequently encountered in the context of vaccine development, an area of intense interest currently due to the emergence or re-emergence of infectious pathoge...

    Authors: Siddhartha Mahanty, Antoine Prigent and Olivier Garraud
    Citation: BMC Immunology 2015 16:31
    Content type: Review Published on:

  23. Neuromyelitis optica (NMO) is an autoimmune disorder of the central nervous system, which is characterized by autoantibodies directed against the water channel aquaporin-4 (AQP4). As one of the main water regu...

    Authors: Martin Juenemann, Tobias Braun, Simone Doenges, Max Nedelmann, Clemens Mueller, Georg Bachmann, Pratibha Singh, Franz Blaes, Tibo Gerriets and Marlene Tschernatsch
    Citation: BMC Immunology 2015 16:30
    Content type: Research article Published on:

  24. Scavenger receptor A (SRA) is expressed predominantly in phagocytic cells playing an essential role in the host immune defense against invading microorganisms. Our previous study reported the presence of SRA i...

    Authors: Ying Chen, Zuxiong Huang, Di Ma, Liqian Chen, Qintao Lai, Xuan Huang, Jia Zhou, Xiaoyong Zhang, Qiang Ma, Zhengliang Chen and Daming Zuo
    Citation: BMC Immunology 2015 16:29
    Content type: Research article Published on:

  25. Multiple sclerosis (MS) is an autoimmune disease in which dysregulated immune cells attack myelin in the central nervous system (CNS), leading to irreversible neuronal degeneration. Our previous studies have d...

    Authors: Enyu Rao, Puja Singh, Yan Li, Yuwen Zhang, Young-In Chi, Jill Suttles and Bing Li
    Citation: BMC Immunology 2015 16:28
    Content type: Research article Published on:

  27. Blood platelets are first aimed at ensuring primary hemostasis. Beyond this role, they have been acknowledged as having functions in the maintenance of the vascular arborescence and, more recently, as being al...

    Authors: Adrien Chabert, Hind Hamzeh-Cognasse, Bruno Pozzetto, Fabrice Cognasse, Mirta Schattner, Ricardo M Gomez and Olivier Garraud
    Citation: BMC Immunology 2015 16:26
    Content type: Review Published on:

  28. HIV-infected long-term non-progressor (LTNP) subjects can prevent viral replication and may harbor useful information for the development of both antibody and active vaccination treatments. In this study we us...

    Authors: Yuxia Hao, Ge Bai, Junping Wang, Longfeng Zhao, Kyle Sutherland, Jianfeng Cai and Chuanhai Cao
    Citation: BMC Immunology 2015 16:25
    Content type: Research article Published on:

  29. Experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis, is induced by immunization of mice with myelin oligodendrocytic glycoprotein (MOG35-55) injections, and after 9 days, mice d...

    Authors: Patricia J McLaughlin, Daniel P McHugh, Marcus J Magister and Ian S Zagon
    Citation: BMC Immunology 2015 16:24
    Content type: Research article Published on:

  31. Monocytes and macrophages produce interleukin (IL)-10, an immunoregulatory cytokine and a potent therapeutic tool for immune disorders. Augmentation of IL-10 production with a concomitant reduction of proinfla...

    Authors: Masanori Inui, Kino Tazawa, Yoshiro Kishi and Toshiyuki Takai
    Citation: BMC Immunology 2015 16:20
    Content type: Research article Published on:

  32. Hantaviruses are emerging zoonotic pathogens which cause hemorrhagic fever with renal syndrome, an immune-mediated pathogenesis is discussed. The aim of the present study was to investigate the role of TGF-β e...

    Authors: Mahmoud Sadeghi, Imad Lahdou, Jakob Ettinger, Mojdeh Heidary Navid, Volker Daniel, Martin Zeier, Jörg Hofmann, Gerhard Opelz and Paul Schnitzler
    Citation: BMC Immunology 2015 16:19
    Content type: Research article Published on:

  35. Vaccination has been a major advance for health care, allowing eradication or reduction of incidence and mortality of various infectious diseases. However, there are major pathogens, such as Human Immunodefici...

    Authors: Mireille Centlivre and Béhazine Combadière
    Citation: BMC Immunology 2015 16:18
    Content type: Review Published on:

  37. Malaria remains a major worldwide public health problem with ~207 million cases and ~627,000 deaths per year, mainly affecting children under five years of age in Africa. Recent efforts at elaborating a geneti...

    Authors: Audrey V Grant, Christian Roussilhon, Richard Paul and Anavaj Sakuntabhai
    Citation: BMC Immunology 2015 16:14
    Content type: Review Published on:

  41. All-trans retinoid acid (ATRA) has been proven to skew Regulatory T cell-T helper 17 cell (Treg-Th17) balance toward Treg in vitro, favoring graft acceptance. However, its in vivo effect after solid organ transpl...

    Authors: Xin Wang, Wentao Wang, Jianjiang Xu, Suqian Wu and Qihua Le
    Citation: BMC Immunology 2015 16:17
    Content type: Research article Published on:

  42. Necrosis of alveolar macrophages following Mycobacterium tuberculosis infection has been demonstrated to play a vital role in the pathogenesis of tuberculosis. Our previous study demonstrated that Wnt/β-catenin s...

    Authors: Xiaoling Wu, Guangcun Deng, Min Li, Yong Li, Chunyan Ma, Yujiong Wang and Xiaoming Liu
    Citation: BMC Immunology 2015 16:16
    Content type: Research article Published on:

  43. C-reactive protein (CRP) exerts prothrombotic effects through dissociating from pentameric CRP (pCRP) into modified or monomeric CRP (mCRP). However, although the high prevalence of venous thromboembolism (VTE...

    Authors: Peng-cheng Xu, Shan Lin, Xiao-wei Yang, Dong-mei Gu, Tie-kun Yan, Li Wei and Bao-li Wang
    Citation: BMC Immunology 2015 16:10
    Content type: Research article Published on:

  45. Polymorphisms in cytokine genes are known to influence cytokine levels, which may influence susceptibility to tuberculosis (TB) infection and disease. Differences in cytokine expression probably determine whet...

    Authors: Yi Hu, Linlin Wu, Dange Li, Qi Zhao, Weili Jiang and Biao Xu
    Citation: BMC Immunology 2015 16:8
    Content type: Research article Published on:

  46. Recent studies indicate a central role for the IL-23/IL-17 axis in the pathogenesis of lupus nephritis (LN) but the importance in the context of treatment outcome is unknown. We studied various cytokines, incl...

    Authors: Agneta Zickert, Petra Amoudruz, Yvonne Sundström, Johan Rönnelid, Vivianne Malmström and Iva Gunnarsson
    Citation: BMC Immunology 2015 16:7
    Content type: Research article Published on:

  47. Homeostatic B Cell-Attracting chemokine 1 (BCA-1) otherwise known as CXCL13 is constitutively expressed in secondary lymphoid organs by follicular dendritic cells (FDC) and macrophages. It is the only known li...

    Authors: Ekaterina Klimatcheva, Tracy Pandina, Christine Reilly, Sebold Torno, Holm Bussler, Maria Scrivens, Alan Jonason, Crystal Mallow, Michael Doherty, Mark Paris, Ernest S Smith and Maurice Zauderer
    Citation: BMC Immunology 2015 16:6
    Content type: Research article Published on:

  48. Excessive and inappropriate immune responses are the hallmark of several autoimmune disorders, including the inflammatory bowel diseases (IBD): Crohn’s disease (CD) and ulcerative colitis (UC). A complex etiol...

    Authors: Jeremy S Schaefer, Taraq Attumi, Antone R Opekun, Bincy Abraham, Jason Hou, Harold Shelby, David Y Graham, Charles Streckfus and John R Klein
    Citation: BMC Immunology 2015 16:5
    Content type: Research article Published on:

  49. Para-phenylenediamine (PPD) is the main allergen causing adverse reactions to hair dyes and a frequent cause of occupational-related skin sensitization among hairdressers and beauticians. The immunologic mecha...

    Authors: Valentina Bordignon, Francesca Palamara, Giorgia Altomonte, Isabella Sperduti, Mario Pietravalle, Claudia Cavallotti, Paola Cordiali-Fei, Maria Pia Fuggetta, Antonio Cristaudo and Fabrizio Ensoli
    Citation: BMC Immunology 2015 16:4
    Content type: Methodology article Published on:

  50. Platelets are instrumental to primary haemostasis; in addition, as they are central to endothelium vascular repair, they play a role in physiological inflammation. Platelets have also been demonstrated to be k...

    Authors: Pauline Damien, Fabrice Cognasse, Marie-Ange Eyraud, Charles-Antoine Arthaud, Bruno Pozzetto, Olivier Garraud and Hind Hamzeh-Cognasse
    Citation: BMC Immunology 2015 16:3
    Content type: Research article Published on:

Featured videos

View featured videos from across the BMC-series journals

Submit manuscript

Annual Journal Metrics

  • 2022 Citation Impact
    3.0 - 2-year Impact Factor
    3.6 - 5-year Impact Factor
    0.808 - SNIP (Source Normalized Impact per Paper)
    0.783 - SJR (SCImago Journal Rank)

    2023 Speed
    26 days submission to first editorial decision for all manuscripts (Median)
    188 days submission to accept (Median)

    2023 Usage 
    671,800 downloads
    176 Altmetric mentions

Follow

Sign up for article alerts and news from this journal

BMC Immunology

ISSN: 1471-2172

Contact us