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BMC Immunology

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  1. Content type: Research article

    Porcine circovirus 2 (PCV2) is a small, non-enveloped DNA virus causing swine lymphocyte depletion and severe impact on the swine industry. The aim of this study was to evaluate the antigenicity and immunogeni...

    Authors: Ling-Chu Hung, Cheng-Yao Yang and Ivan-Chen Cheng

    Citation: BMC Immunology 2017 18:25

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  2. Content type: Research article

    Activation of inflammasome contributes to the clearance of intracellular bacteria. C-terminus of E. coli EscI protein can activate NLRC4 (NLR family, CARD domain containing-4) inflammasome in macrophages. The pur...

    Authors: Maozhi Hu, Weixin Zhao, Wei Gao, Wenhua Li, Chuang Meng, Qiuxiang Yan, Yuyang Wang, Xiaohui Zhou, Shizhong Geng, Zhiming Pan, Guiyou Cui and Xinan Jiao

    Citation: BMC Immunology 2017 18:21

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  3. Content type: Research article

    Delayed wound healing reduces the quality of life (QOL) of patients. Thus, understanding the mechanism of wound healing is indispensable for better management. However, the role of innate immunity in wound hea...

    Authors: Kazuhide Takada, Shihoko Komine-Aizawa, Naoko Hirohata, Quang Duy Trinh, Atsuyoshi Nishina, Hirokazu Kimura and Satoshi Hayakawa

    Citation: BMC Immunology 2017 18:19

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  4. Content type: Research article

    Type 1 diabetes is an autoimmune disease caused by T cell-mediated destruction of the insulin-producing β-cells in the pancreas. Therefore, approaches that effectively halt the pathogenic T cell response are p...

    Authors: Cristina Vazquez-Mateo, Justin Collins, Michelle Fleury and Hans Dooms

    Citation: BMC Immunology 2017 18:18

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  5. Content type: Research article

    To assess the impact of disease activity on health-related quality of life (HRQoL) in systemic lupus erythematosus (SLE).

    Authors: Benjamin Chaigne, Carlo Chizzolini, Thomas Perneger, Marten Trendelenburg, Uyen Huynh-Do, Eric Dayer, Thomas Stoll, Johannes von Kempis and Camillo Ribi

    Citation: BMC Immunology 2017 18:17

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  6. Content type: Methodology article

    In healthy individuals, Cytomegalovirus (CMV) infection is efficiently controlled by CMV-specific cell-mediated immunity (CMI). Functional impairment of CMI in immunocompromized individuals however can lead to...

    Authors: Sascha Barabas, Theresa Spindler, Richard Kiener, Charlotte Tonar, Tamara Lugner, Julia Batzilla, Hanna Bendfeldt, Anne Rascle, Benedikt Asbach, Ralf Wagner and Ludwig Deml

    Citation: BMC Immunology 2017 18:14

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  7. Content type: Research article

    Uncontrolled cytomegalovirus (CMV) replication in immunocompromised solid-organ transplant recipients is a clinically relevant issue and an indication of impaired CMV-specific cell-mediated immunity (CMI). Pri...

    Authors: Bernhard Banas, Carsten A. Böger, Gerhard Lückhoff, Bernd Krüger, Sascha Barabas, Julia Batzilla, Mathias Schemmerer, Josef Köstler, Hanna Bendfeldt, Anne Rascle, Ralf Wagner, Ludwig Deml, Joachim Leicht and Bernhard K. Krämer

    Citation: BMC Immunology 2017 18:15

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  8. Content type: Research article

    Japanese encephalitis virus (JEV) is a mosquito-borne flavivirus that causes Japanese Encephalitis (JE) and Acute Encephalitis Syndrome (AES) in humans. Genotype-I (as co-circulating cases with Genotype-III) w...

    Authors: Shyamashree Banerjee, Parth Sarthi Sen Gupta and Amal Kumar Bandyopadhyay

    Citation: BMC Immunology 2017 18:13

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  9. Content type: Research article

    Lipopolysaccharide (LPS) induces acute liver injury and the complex mechanisms include the activation of toll like receptor 4 (TLR4) signaling pathway in many species. However, immuno-pathological changes duri...

    Authors: Xi-Yao Huang, Abdur Rahman Ansari, Hai-Bo Huang, Xing Zhao, Ning-Ya Li, Zhi-Jian Sun, Ke-Mei Peng, Juming Zhong and Hua-Zhen Liu

    Citation: BMC Immunology 2017 18:12

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  10. Content type: Research article

    Tuberculosis (TB) is a major global public health problem. New treatment methods on TB are urgently demanded. In this study, Mycobacterium tuberculosis (MTB) rv2190c DNA vaccine was prepared and its immunogenicit...

    Authors: Yan Liang, Xiaoyan Zhang, Xuejuan Bai, Li Xiao, Xiaomei Wang, Junxian Zhang, Yourong Yang, Jinying Song, Lan Wang and Xueqiong Wu

    Citation: BMC Immunology 2017 18:11

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  11. Content type: Research article

    Allergy to cat epithelia is highly prevalent, being the major recommendation for allergy sufferers its avoidance. However, this is not always feasible. Allergen specific immunotherapy is therefore recommended ...

    Authors: María Morales, Mayte Gallego, Victor Iraola, Marta Taulés, Eliandre de Oliveira, Raquel Moya and Jerónimo Carnés

    Citation: BMC Immunology 2017 18:10

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  12. Content type: Research article

    Patients experiencing large thermal injuries are susceptible to opportunistic infections that can delay recovery and lead to sepsis. Dendritic cells (DC) are important for the detection of pathogens and activa...

    Authors: Leon Bae, Julia K. Bohannon, Weihua Cui, Monika Vinish and Tracy Toliver-Kinsky

    Citation: BMC Immunology 2017 18:9

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  13. Content type: Research article

    Hyperactive secretion and pathogenic effects of interleukin (IL)-17 and IgA have been detected in different arthropathies. Recent evidence has revealed that TH17 cytokines regulate mucosal IgA secretion. However,...

    Authors: Ricardo Javier Eliçabe, Juan Eduardo Silva, Mabel Noemí Dave, María Gabriela Lacoste, Héctor Tamashiro, Rodrigo Blas, Alicia Munarriz, Gabriel Adrián Rabinovich and María Silvia Di Genaro

    Citation: BMC Immunology 2017 18:8

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  14. Content type: Research article

    While tumor necrosis factor alpha (TNF-α) inhibitors (TNFi) and other biologics are very effective against autoimmune diseases, they can also cause infectious diseases. Therefore, it is important to clarify wh...

    Authors: Shoichi Fukui, Hideki Nakamura, Yoshiko Takahashi, Naoki Iwamoto, Hiroo Hasegawa, Katsunori Yanagihara, Tatsufumi Nakamura, Akihiko Okayama and Atsushi Kawakami

    Citation: BMC Immunology 2017 18:7

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  15. Content type: Research article

    Comprehensive understanding of cellular immune subsets involved in regulation of tumor progression is central to the development of cancer immunotherapies. Single cell immunophenotyping has historically been a...

    Authors: Elma Kadić, Raymond J. Moniz, Ying Huo, An Chi and Ilona Kariv

    Citation: BMC Immunology 2017 18:6

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  16. Content type: Research article

    The role of pathogen specific cellular immune responses against the eliciting pathogen in development of post-infectious chronic fatigue syndrome (PI-CFS) is not known and such studies are difficult to perform...

    Authors: Kurt Hanevik, Einar Kristoffersen, Kristine Mørch, Kristin Paulsen Rye, Steinar Sørnes, Staffan Svärd, Øystein Bruserud and Nina Langeland

    Citation: BMC Immunology 2017 18:5

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  17. Content type: Research article

    The spleen is an important site for hematopoiesis. It supports development of myeloid cells from bone marrow-derived precursors entering from blood. Myeloid subsets in spleen are not well characterised althoug...

    Authors: Ying-Ying Hey, Benjamin Quah and Helen C. O’Neill

    Citation: BMC Immunology 2017 18:4

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  18. Content type: Research Article

    Oxidative damage present in obese/overweight mothers may lead to further oxidative stress conditions or inflammation in maternal and cord blood samples. Thirty-four pregnant women/newborn pairs were included i...

    Authors: María Hernández-Trejo, Araceli Montoya-Estrada, Yessica Torres-Ramos, Aurora Espejel-Núñez, Alberto Guzmán-Grenfell, Rosa Morales-Hernández, Maricruz Tolentino-Dolores and Estibalitz Laresgoiti-Servitje

    Citation: BMC Immunology 2017 18:3

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  19. Content type: Research article

    CD4+CD25+ regulatory T (Treg) cells suppress tumor immunity by inhibiting immune cells. Manipulation of Treg cells represents a new strategy for cancer treatment. Zoledronic acid (ZA), a nitrogen-containing bisph...

    Authors: Hsien Liu, Shih-Han Wang, Shin-Cheh Chen, Ching-Ying Chen, Jo-Lin Lo and Tsun-Mei Lin

    Citation: BMC Immunology 2016 17:45

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  20. Content type: Methodology article

    The Luminex bead-based multiplex assay is useful for quantifying immune mediators such as cytokines and chemokines. Cross-comparisons of reagents for this technique from different suppliers have already been p...

    Authors: Mathieu Surenaud, Céline Manier, Laura Richert, Rodolphe Thiébaut, Yves Levy, Sophie Hue and Christine Lacabaratz

    Citation: BMC Immunology 2016 17:44

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  21. Content type: Research article

    The Major Histocompatibility Complex (MHC) class I family of genes encode for molecules that have well-conserved structures, but have evolved to perform diverse functions. The availability of the gray, short-t...

    Authors: Katina V. Krasnec, Anthony T. Papenfuss and Robert D. Miller

    Citation: BMC Immunology 2016 17:43

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  22. Content type: Research article

    The small intestine is a specialized compartment were close interactions take place between host, microbes, food antigens and dietary fatty acids. Dietary fats get absorbed by epithelial cells and processed in...

    Authors: Jeroen van Bergenhenegouwen, Aletta D. Kraneveld, Lieke Rutten, Johan Garssen, Arjan P. Vos and Anita Hartog

    Citation: BMC Immunology 2016 17:42

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