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  1. Research article

    Adverse events following immunization with pentavalent vaccine: experiences of newly introduced vaccine in Iran

    The most important factors that affect the incidence of vaccine-related complications are the constituent biological components of the vaccine, injection site reactions, age and sex. The aim of this study is t...

    Manoochehr Karami, Pegah Ameri, Jalal Bathaei, Zeinab Berangi, Tahereh Pashaei, Ali Zahiri, Seyed Mohsen Zahraei, Hussein Erfani and Koen Ponnet

    BMC Immunology 2017 18:42

    Published on: 23 August 2017

  2. Research article

    JAK inhibitor has the amelioration effect in lupus-prone mice: the involvement of IFN signature gene downregulation

    We previously reported that JAK–STAT-pathway mediated regulation of IFN-regulatory factor genes could play an important role in SLE pathogenesis. Here, we evaluated the efficacy of the JAK inhibitor tofacitini...

    Keigo Ikeda, Kunihiro Hayakawa, Maki Fujishiro, Mikiko Kawasaki, Takuya Hirai, Hiroshi Tsushima, Tomoko Miyashita, Satoshi Suzuki, Shinji Morimoto, Naoto Tamura, Kenji Takamori, Hideoki Ogawa and Iwao Sekigawa

    BMC Immunology 2017 18:41

    Published on: 22 August 2017

  3. Research article

    Blocking IL-10 signalling at the time of immunization does not increase unwanted side effects in mice

    Cancer therapeutic vaccine induced cytotoxic T cell (CTL) responses are pivotal for the killing of tumour cells. Blocking interleukin 10 (IL-10) signalling at the time of immunization increases vaccine induced...

    Guoying Ni, Zaowen Liao, Shu Chen, Tianfang Wang, Jianwei Yuan, Xuan Pan, Kate Mounsey, Shelley Cavezza, Xiaosong Liu and Ming Q. Wei

    BMC Immunology 2017 18:40

    Published on: 15 August 2017

  4. Research article

    Characteristics of the specific humoral response in patients with advanced solid tumors after active immunotherapy with a VEGF vaccine, at different antigen doses and using two distinct adjuvants

    CIGB-247, a VSSP-adjuvanted VEGF-based vaccine, was evaluated in a phase I clinical trial in patients with advanced solid tumors (CENTAURO). Vaccination with the maximum dose of antigen showed an excellent saf...

    Javier Sánchez Ramírez, Yanelys Morera Díaz, Mónica Bequet-Romero, Francisco Hernández-Bernal, Katty-Hind Selman-Housein Bernal, Ana de la Torre Santos, Eduardo Rafael Santiesteban Álvarez, Yenima Martín Bauta, Cimara H. Bermúdez Badell, Josué de la Torre Pupo, Jorge V. Gavilondo and Marta Ayala Avila

    BMC Immunology 2017 18:39

    Published on: 26 July 2017

  5. Research article

    Detection of IL-9 producing T cells in the PBMCs of allergic asthmatic patients

    Interleukin-9 (IL-9) was reported as an active participant in the pathogenesis of allergic asthma. This study aimed to investigate the major source ofIL-9 and its effect on interferon γ (IFN-γ) and immunoglobu...

    Lei Jia, Ying Wang, Jiangping Li, Sha Li, Yannan Zhang, Juan Shen, Weiping Tan and Changyou Wu

    BMC Immunology 2017 18:38

    Published on: 19 July 2017

  6. Research article

    Mercury alters endogenous phosphorylation profiles of SYK in murine B cells

    Epidemiological evidence and animal models suggest that exposure to low and non-neurotoxic concentrations of mercury may contribute to idiosyncratic autoimmune disease. Since defects in function and signaling ...

    Joseph A. Caruso, Nicholas Carruthers, Namhee Shin, Randal Gill, Paul M. Stemmer and Allen Rosenspire

    BMC Immunology 2017 18:37

    Published on: 17 July 2017

  7. Research article

    γδTFH cells promote B cell maturation and antibody production in neuroblastoma

    Previous studies have shown that γδ TFH cells are capable of modulating antibody production in immunized and infected mouse model. In recent studies, human γδ TFH cells are shown to contribute to the activatio...

    Wenjun Mou, Wei Han, Xiaoli Ma, Xiaolin Wang, Hong Qin, Wen Zhao, Xiaoya Ren, Xi Chen, Wei Yang, Haiyan Cheng, Xisi Wang, Hui Zhang, Xin Ni, Huanmin Wang and Jingang Gui

    BMC Immunology 2017 18:36

    Published on: 7 July 2017

  8. Research article

    Autoantibodies against BAFF, APRIL or IL21 - an alternative pathogenesis for antibody-deficiencies?

    The ability of anti-cytokine antibodies to play a disease-causing role in the pathogenesis of immunodeficiencies is widely accepted. The aim of this study was to investigate whether autoantibodies against BAFF...

    Marian-Christopher Pott, Natalie Frede, Jennifer Wanders, Lennart Hammarström, Erik-Oliver Glocker, Cristina Glocker, Fariba Tahami and Bodo Grimbacher

    BMC Immunology 2017 18:34

    Published on: 26 June 2017

  9. Research article

    The imbalance of Th17/Treg cells is involved in the progression of nonalcoholic fatty liver disease in mice

    Non-alcoholic fatty liver disease (NAFLD) is a common, chronic liver disease worldwide. Recent studies have shown that T helper (Th) 17 and regulatory T (Treg) cells play critical roles in various disorders of...

    Beihui He, Liyan Wu, Wei Xie, Yitong Shao, Jianping Jiang, Zhenzhong Zhao, Maoxiang Yan, Zhiyun Chen and Dawei Cui

    BMC Immunology 2017 18:33

    Published on: 24 June 2017

  10. Research

    A model of auto immune response

    In this work, we develop a theoretical model of an auto immune response. This is based on modifications of standard second messenger trigger models using both signalling pathways and diffusion and a macro leve...

    James K. Peterson, Alison M. Kesson and Nicholas J. C. King

    BMC Immunology 2017 18(Suppl 1):24

    Published on: 21 June 2017

    This article is part of a Supplement: Volume 18 Supplement 1

  11. Research

    Experimental validation of the RATE tool for inferring HLA restrictions of T cell epitopes

    The RATE tool was recently developed to computationally infer the HLA restriction of given epitopes from immune response data of HLA typed subjects without additional cumbersome experimentation.

    Sinu Paul, Cecilia S. Lindestam Arlehamn, Veronique Schulten, Luise Westernberg, John Sidney, Bjoern Peters and Alessandro Sette

    BMC Immunology 2017 18(Suppl 1):20

    Published on: 21 June 2017

    This article is part of a Supplement: Volume 18 Supplement 1

  12. Methodology article

    Generation of populations of antigen-specific cytotoxic T cells using DCs transfected with DNA construct encoding HER2/neu tumor antigen epitopes

    Recent fundamental and clinical studies have confirmed the effectiveness of utilizing the potential of the immune system to remove tumor cells disseminated in a patient’s body. Cytotoxic T lymphocytes (CTLs) a...

    Maria Kuznetsova, Julia Lopatnikova, Julia Khantakova, Rinat Maksyutov, Amir Maksyutov and Sergey Sennikov

    BMC Immunology 2017 18:31

    Published on: 20 June 2017

  13. Research article

    Monocyte differentiation and macrophage priming are regulated differentially by pentraxins and their ligands

    Circulating bone marrow-derived monocytes can leave the blood, enter a tissue, and differentiate into M1 inflammatory, M2a remodeling/fibrotic, or M2c/Mreg resolving/immune-regulatory macrophages. Macrophages ...

    Darrell Pilling, Elkin Galvis-Carvajal, Tejas R. Karhadkar, Nehemiah Cox and Richard H. Gomer

    BMC Immunology 2017 18:30

    Published on: 15 June 2017

  14. Research article

    Long-term leukocyte reconstitution in NSG mice transplanted with human cord blood hematopoietic stem and progenitor cells

    Humanized mice (hu mice) are based on the transplantation of hematopoietic stem and progenitor cells into immunodeficient mice and have become important pre-clinical models for biomedical research. However, da...

    Annette Audigé, Mary-Aude Rochat, Duo Li, Sandra Ivic, Audrey Fahrny, Christina K. S. Muller, Gustavo Gers-Huber, Renier Myburgh, Simon Bredl, Erika Schlaepfer, Alexandra U. Scherrer, Stefan P. Kuster and Roberto F. Speck

    BMC Immunology 2017 18:28

    Published on: 30 May 2017

  15. Research article

    The immunoregulatory role of alpha enolase in dendritic cell function during Chlamydia infection

    We have previously reported that interleukin-10 (IL-10) deficient dendritic cells (DCs) are potent antigen presenting cells that induced elevated protective immunity against Chlamydia. To further investigate the ...

    Khamia Ryans, Yusuf Omosun, Danielle N. McKeithen, Tankya Simoneaux, Camilla C. Mills, Nathan Bowen, Francis O. Eko, Carolyn M. Black, Joseph U. Igietseme and Qing He

    BMC Immunology 2017 18:27

    Published on: 19 May 2017

  16. Research article

    The cytokine polymorphisms affecting Th1/Th2 increase the susceptibility to, and severity of, chronic ITP

    T-helper cell type 1 (Th1) polarization in chronic immune thrombocytopenia (cITP) has been reported at the protein and mRNA levels. We evaluated the impact of Th1/Th2 cytokine and cytokine receptor functional ...

    Noriyuki Takahashi, Takayuki Saitoh, Nanami Gotoh, Yasuhiro Nitta, Lobna Alkebsi, Tetsuhiro Kasamatsu, Yusuke Minato, Akihiko Yokohama, Norifumi Tsukamoto, Hiroshi Handa and Hirokazu Murakami

    BMC Immunology 2017 18:26

    Published on: 16 May 2017

  17. Research article

    Recombinant Salmonella expressing SspH2-EscI fusion protein limits its colonization in mice

    Activation of inflammasome contributes to the clearance of intracellular bacteria. C-terminus of E. coli EscI protein can activate NLRC4 (NLR family, CARD domain containing-4) inflammasome in macrophages. The pur...

    Maozhi Hu, Weixin Zhao, Wei Gao, Wenhua Li, Chuang Meng, Qiuxiang Yan, Yuyang Wang, Xiaohui Zhou, Shizhong Geng, Zhiming Pan, Guiyou Cui and Xinan Jiao

    BMC Immunology 2017 18:21

    Published on: 3 May 2017

  18. Research article

    Poly I:C induces collective migration of HaCaT keratinocytes via IL-8

    Delayed wound healing reduces the quality of life (QOL) of patients. Thus, understanding the mechanism of wound healing is indispensable for better management. However, the role of innate immunity in wound hea...

    Kazuhide Takada, Shihoko Komine-Aizawa, Naoko Hirohata, Quang Duy Trinh, Atsuyoshi Nishina, Hirokazu Kimura and Satoshi Hayakawa

    BMC Immunology 2017 18:19

    Published on: 24 April 2017

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