Articles

Clinical relevance of glomerular IgM deposition in patients with lupus nephritis

The aim of the study was to investigate the clinical relevance of IgM deposition in patients with lupus nephritis (LN) in a large cohort.

Authors: Fengmei Wang, Jirong Yu, Lei Zhang, Yan Zhang, Jie Zhang, Bicheng Liu and Xiaowei Yang

Repression of the expression of proinflammatory genes by mitochondrial transcription factor A is linked to its alternative splicing regulation in human lung epithelial cells

Mitochondrial transcription factor A (TFAM) is associated with a number of neurodegenerative diseases and also with asthma. TFAM deficiency-induced mitochondrial DNA stress primes the antiviral innate immune r...

Authors: Jinsong Luo, Hong Liu, Daniel K. Jun Li, Bin Song and Yi Zhang

Transmembrane signaling molecules play a key role in the pathogenesis of IgA nephropathy: a weighted gene co-expression network analysis study

Immunoglobulin A nephropathy (IgAN) is one of the most common primary glomerulonephritis and a serious health concern worldwide; though still the underlying molecular mechanisms of IgAN are yet to be known and...

Authors: Alieh Gholaminejad, Amir Roointan and Yousof Gheisari

Dimethyl itaconate alleviates the pyroptosis of macrophages through oxidative stress

Macrophages are involved in the pathophysiology of many diseases as critical cells of the innate immune system. Pyroptosis is a form of macrophage death that induces cytokinesis of phagocytic substances in the...

Authors: Shan-Shan Huang, Dong-Yang Guo, Bing-Bing Jia, Guo-Long Cai, Jing Yan, Yan Lu and Zhou-Xin Yang

Natural immunogenic properties of bioinformatically predicted linear B-cell epitopes of dengue envelope and pre-membrane proteins

The natural antibody responses to B-cell epitopes from dengue structural proteins were assessed using immune sera from people having well-defined past dengue infections with one of the four serotypes.

Authors: Mahesha N. Nadugala, Chandima Jeewandara, Ramesh S. Jadi, Gathsaurie N. Malavige, Aravinda M. de Silva, Prasad H. Premaratne and Charitha L. Goonasekara

Humoral and cellular response to SARS-CoV-2 BNT162b2 mRNA vaccine in hemodialysis patients

Hemodialysis (HD) patients have an increased risk of acquiring infections due to many health care contacts and may, in addition, have a suboptimal response to vaccination and a high mortality from Covid-19 inf...

Authors: Jan Melin, Maria K. Svensson, Bo Albinsson, Ola Winqvist and Karlis Pauksens

Soluble programmed death molecule 1 (sPD-1) as a predictor of interstitial lung disease in rheumatoid arthritis

Previous studies have indicated that the programmed death molecule 1 (PD-1) signaling pathway may play a key role in rheumatoid arthritis (RA). However, the pathogenesis of rheumatoid arthritis-related interst...

Authors: Li Xu, Lichun Jiang, Liuyan Nie, Songzhao Zhang, Lei Liu, Yan Du and Jing Xue

Immunogenicity of a new enhanced tetanus-reduced dose diphtheria-acellular pertussis (Tdap) vaccine against Bordetella pertussis in a murine model

The necessity of the tetanus-reduced dose diphtheria-acellular pertussis (Tdap) vaccine in adolescence and adults has been emphasized since the resurgence of small-scale pertussis in Korea and worldwide due to...

Authors: Kyu Ri Kang, Dong Ho Huh, Ji Ahn Kim and Jin Han Kang

Activation of Toll-like receptor 2 enhances peripheral and tumor-infiltrating CD8⁺ T cell cytotoxicity in patients with gastric cancer

Toll-like receptors (TLRs) play central roles in the initiation of innate immune response, and also control adaptive immunity activation. Thus, the aim of the study was to investigate the regulation of TLR act...

Authors: Junli Xu, Rongya Guo, Jing Jia, Yun He and Shuixiang He

Highly individual- and tissue-specific expression of glycoprotein group A and B blood antigens in the human kidney and liver

Currently, research on the quantitative distribution of ABO antigens in different organs and tissues remains limited. We aimed to examine the individual characteristics of blood group glycoprotein A and B anti...

Authors: Xianding Wang, Fan Zhang, Yamei Jiang, Zilin Xu, Xiaobing Feng, Linde Li, Yu Fan, Turun Song, Yunying Shi, Zhongli Huang and Tao Lin

An efficient method to identify virus-specific TCRs for TCR-T cell immunotherapy against virus-associated malignancies

Adoptive transfer of T cells genetically engineered with a T cell receptor (TCR) is a promising cancer treatment modality that requires the identification of TCRs with good characteristics. Most T cell cloning...

Authors: Lei Chen, Lianhua Dong, Yipeng Ma, Juntao Wang, Dongjuan Qiao, Geng Tian and Mingjun Wang

Neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, and other hematological parameters in psoriasis patients

Psoriasis is a chronic immune‐mediated skin disorder. Systemic inflammation plays an important role in the pathogenesis of psoriasis.

Authors: Wen-Ming Wang, Chao Wu, Yi-Meng Gao, Feng Li, Xiao-Ling Yu and Hong-Zhong Jin

Analysis of multivariate longitudinal immuno-epidemiological data using a pairwise joint modelling approach

Immuno-epidemiologists are often faced with multivariate outcomes, measured repeatedly over time. Such data are characterised by complex inter- and intra-outcome relationships which must be accounted for durin...

Authors: Lawrence Lubyayi, Patrice A. Mawa, Stephen Cose, Alison M. Elliott, Jonathan Levin and Emily L. Webb

Phenotypic and immune functional profiling of patients with suspected Mendelian Susceptibility to Mycobacterial Disease in South Africa

Mendelian Susceptibility to Mycobacterial Disease (MSMD) is a primary immunodeficiency (PID) characterised by a predisposition to infection by weakly-pathogenic mycobacteria. In countries with a high prevalenc...

Authors: Ansia van Coller, Brigitte Glanzmann, Helena Cornelissen, Marlo Möller, Craig Kinnear, Monika Esser and Richard Glashoff

Association between serum markers of the humoral immune system and inflammation in the Swedish AMORIS study

Although the onset of inflammatory cascades may profoundly influence the nature of antibody responses, the interplay between inflammatory and humoral (antibody) immune markers remains unclear. Thus, we explore...

Authors: Aida Santaolalla, Sam Sollie, Ali Rislan, Debra H. Josephs, Niklas Hammar, Goran Walldius, Hans Garmo, Sophia N. Karagiannis and Mieke Van Hemelrijck

The augment of regulatory T cells undermines the efficacy of anti-PD-L1 treatment in cervical cancer

Immune checkpoint inhibitors have aroused great expectation of tumor eradication. However, the effect of anti-PD-L1 treatment for cervical cancer is unsatisfactory and the underlying antagonist to anti-PD-L1 e...

Authors: Fengying Xu, Fengying Zhang, Qian Wang, Ying Xu, Shuifang Xu, Caihong Zhang and Lihua Wang

Innate lymphoid cell dysfunction during long-term suppressive antiretroviral therapy in an African cohort

Innate lymphoid cells (ILC) are lymphoid lineage innate immune cells that do not mount antigen-specific responses due to their lack of B and T-cell receptors. ILCs are predominantly found at mucosal surfaces, ...

Authors: Rose Nabatanzi, Lois Bayigga, Stephen Cose, Glenda Canderan, Sarah Rowland Jones, Moses Joloba and Damalie Nakanjako

Intratumoral regulatory T cells from colon cancer patients comprise several activated effector populations

Intratumoral regulatory T cells (Treg) in colon cancer are a heterogeneous cell population, with potential impact on patient outcome. Generally, a high Treg infiltration has been correlated to a worse patient ...

Authors: Louis Szeponik, Filip Ahlmanner, Patrik Sundström, William Rodin, Bengt Gustavsson, Elinor Bexe Lindskog, Yvonne Wettergren and Marianne Quiding-Järbrink

Pharmacological activation of rev-erbα suppresses LPS-induced macrophage M1 polarization and prevents pregnancy loss

Circadian rhythm is an important player for reproduction. Rev-erbα, a significant clock gene, is involved in regulating cell differentiation, inflammation and metabolism. Macrophage polarization plays crucial ...

Authors: Liyuan Cui, Feng Xu, Songcun Wang, Xinyi Li, Haiyan Lin, Yan Ding and Meirong Du

The transmembrane domain and luminal C-terminal region independently support invariant chain trimerization and assembly with MHCII into nonamers

Invariant chain (CD74, Ii) is a multifunctional protein expressed in antigen presenting cells. It assists the ER exit of various cargos and serves as a receptor for the macrophage migration inhibitory factor. ...

Authors: Maryse Cloutier, Jean-Simon Fortin and Jacques Thibodeau

Identification of active small-molecule modulators targeting the novel immune checkpoint VISTA

Cancer immunotherapy has gained increasing popularity as a novel approach to treat cancer. A member of the B7 family, V-domain immunoglobulin suppressor of T-cell activation (VISTA) is a novel immune checkpoin...

Authors: Ting-ting Li, Jing-wei Jiang, Chen-xin Qie, Chun-xiao Xuan, Xin-lei Hu, Wan-mei Liu, Wen-ting Chen and Jun Liu

Critical role of triglycerides for adiponectin levels in hepatitis C: a joint study of human and HCV core transgenic mice

Both hepatitis C virus (HCV) infection and adiponectin are critically involved in metabolism. The reversal and associations of altering adiponectin levels after sustained virological responses (SVRs) following...

Authors: Ming-Ling Chang, Jing-Hong Hu, Li-Heng Pao, Ming-Shyan Lin, Chia-Jung Kuo, Shiang-Chi Chen, Chun-Ming Fan, Ming-Yu Chang and Rong-Nan Chien

Factors associated with IgG levels in adults with IgG subclass deficiency

Factors associated with IgG levels in adults with IgG subclass deficiency (IgGSD) are incompletely understood. We studied adults with IgGSD with subnormal IgG1 only, subnormal IgG1/IgG3, or subnormal IgG3 only...

Authors: James C. Barton, Jackson Clayborn Barton, Luigi F. Bertoli and Ronald T. Acton

Anti-inflammatory protein TNFα-stimulated gene-6 (TSG-6) reduces inflammatory response after brain injury in mice

Current research suggests that the glial scar surrounding penetrating brain injuries is instrumental in preserving the surrounding uninjured tissue by limiting the inflammatory response to the injury site. We ...

Authors: Kazadi Nadine Mutoji, Mingxia Sun, Amanda Nash, Sudan Puri, Vincent Hascall and Vivien J. Coulson-Thomas

Angiopoietin 1 release from human neutrophils is independent from neutrophil extracellular traps (NETs)

Neutrophils induce the synthesis and release of angiopoietin 1 (Ang1), a cytosolic growth factor involved in angiogenesis and capable of inducing several pro-inflammatory activities in neutrophils. Neutrophils...

Authors: Elcha Charles, Benjamin L. Dumont, Steven Bonneau, Paul-Eduard Neagoe, Louis Villeneuve, Agnès Räkel, Michel White and Martin G. Sirois

Variable clinical characteristics and laboratory results in five patients with Chinese Good's syndrome (thymoma and hypogammaglobulinemia): an 8-year retrospective analysis in a university hospital in China

Good's syndrome (GS) is a rare secondary immunodeficiency disease presenting as thymoma and hypogammaglobulinemia. Due to its rarity, the diagnosis of GS is often missed.

Authors: Jinyao Ni, Junwu Zhang, Yanxia Chen, Weizhong Wang and Jinlin Liu

Targeted immune epitope prediction to HHLA2 and MAGEB5 protein variants as therapeutic approach to related viral diseases

Targeted immunotherapy is mostly associated with cancer treatment wherein designed molecules engage signaling pathways and mutant proteins critical to the survival of the cell. One of several genetic approache...

Authors: Daniel A. Achinko, Anton Dormer, Mahesh Narayanan and Elton F. Norman

Prevalence of human leukocyte antigen HLA-B*57:01 in individuals with HIV in West and Central Africa

The presence of the human leukocyte antigen HLA-B*57:01 is associated with the development of a hypersensitivity reaction to abacavir (ABC). Limited data exist on HLA-B*57:01 prevalence in individuals with HIV...

Authors: Malewe Kolou, Armel Poda, Zelica Diallo, Esther Konou, Tatiana Dokpomiwa, Jacques Zoungrana, Mounerou Salou, Lionèle Mba-Tchounga, André Bigot, Abdoul-Salam Ouedraogo, Marielle Bouyout-Akoutet, Didier K. Ekouevi and Serge P. Eholie

Differential long non-coding RNA expression profile and function analysis in primary Sjogren’s syndrome

Primary Sjögren’s syndrome (pSS) is a chronic autoimmune disease characterized by abnormal immune cell activation. This study aimed to investigate differentially expressed long non-coding RNA (lncRNA) in perip...

Authors: Xiaochan Chen, Qi Cheng, Yan Du, Lei Liu and Huaxiang Wu

Type 2 innate lymphoid cells from Id1 transgenic mice alleviate skin manifestations of graft-versus-host disease

Acute graft-versus-host disease (aGVHD) is one of the most common causes of morbidity for patients undergoing allogeneic stem cell transplantation. There is preliminary evidence that activated Group 2 innate l...

Authors: Anand Srinivasan, Sandra Bajana, Aneta Pankow, Carrie Yuen, Rikin K. Shah and Xiao-Hong Sun

Correction to: Mutant glucocorticoid receptor binding elements on the interleukin-6 promoter regulate dexamethasone effects

Authors: Wen-Teng Chang, Ming-Yuan Hong, Chien-Liang Chen, Chi-Yuan Hwang, Cheng-Chieh Tsai and Chia-Chang Chuang

Downregulation of NKG2DLs by TGF-β in human lung cancer cells

Transforming growth factor beta (TGF-β) is a typical immuno-inhibitory cytokine and highly secreted by lung cancer cells. It was supposed that its immunosuppressive effects to NK cell might be related with the...

Authors: Young Shin Lee, Hojung Choi, Hae-Ryung Cho, Woo-Chang Son, You-Soo Park, Chi-Dug Kang and Jaeho Bae

Optimizing interleukin-2 concentration, seeding density and bead-to-cell ratio of T-cell expansion for adoptive immunotherapy

The successful ex vivo expansion of T-cells in great numbers is the cornerstone of adoptive cell therapy. We aimed to achieve the most optimal T-cell expansion condition by comparing the expansion of T-cells a...

Authors: Sasan Ghaffari, Monireh Torabi-Rahvar, Sajjad Aghayan, Zahra Jabbarpour, Kobra Moradzadeh, Azadeh Omidkhoda and Naser Ahmadbeigi

Serum IL-35 is decreased in overweight patients with rheumatoid arthritis: its correlation with Th1/Th2/Th17-related cytokines

Obesity is correlated with worse drug responses and high disease activity in patients with rheumatoid arthritis (RA). Interleukin (IL)-35 is a novel anti-inflammatory cytokine that mainly produced by regulator...

Authors: Yuxuan Li, Yang Jie, Xiaofei Wang and Jing Lu

Assessment of CD27 expression on T-cells as a diagnostic and therapeutic tool for patients with smear-negative pulmonary tuberculosis

There is a global focus on illness diagnosis in smear-negative and latent tuberculosis infectious populations (SN-TB and LTBI). CD27 has been suggested to play a direct role in active TB. Little is known about...

Authors: Feifan Xu, Haiyun Zhang, Xiaoyan Si, Junlin Chen, Yuhao Chen, Xiaopeng Cui and Yongwei Qin

Immunization with Pneumocystis carinii A12_1–85 antigen activates immune function against P. carinii

Pneumocystis pneumonia (PcP), which is caused by Pneumocystis carinii, is a life-threatening infection that affects immunocompromised individuals. Unfortunately, chemoprophylaxis and dapsone are only effective fo...

Authors: Tong Tong, Zhongxin Wang, Yuanhong Xu and Jilu Shen

Upregulation of PD-1 expression on circulating CD8+ but not CD4+ T cells is associated with tuberculosis infection in health care workers

Health care workers (HCWs) are at risk for occupationally acquired Mycobacterium tuberculosis infection and tuberculosis (TB) disease due to repeated exposure to workplace tubercle bacilli. To determine whether c...

Authors: Cui-lin Shi, Jian-ping Zhang, Ping Xu, Jin Li, Jie Shen, Mei-ying Wu, Zhi-jian Ye, Xin Yu, Hua-feng Song, Hui Chen, Jun-chi Xu, Yu Pang and Jian-an Huang

Cisplatin-based chemoradiation decreases telomerase-specific CD4 TH1 response but increases immune suppressive cells in peripheral blood

The synergistic effect of chemoradiation (CRT) has been previously demonstrated in several cancer types. Here, we investigated the systemic immune effects of CRT in patients with lung or head and neck cancer.

Authors: Jihane Boustani, Elodie Lauret Marie Joseph, Etienne Martin, Salim Benhmida, Benoit Lecoester, Florent Tochet, Céline Mirjolet, Cédric Chevalier, David Thibouw, Noémie Vulquin, Stéphanie Servagi, Xushan Sun and Olivier Adotévi

Transcriptomics of type 2 diabetic and healthy human neutrophils

Chronic inflammatory diseases, including diabetes and cardiovascular disease, are heterogeneous and often co-morbid, with increasing global prevalence. Uncontrolled type 2 diabetes (T2D) can result in severe i...

Authors: Sarah E. Kleinstein, Jamison McCorrison, Alaa Ahmed, Hatice Hasturk, Thomas E. Van Dyke and Marcelo Freire

Naïve CD4⁺ cell counts significantly decay and high HIV RNA levels contribute to immunological progression in long-term non-progressors infected with HIV by blood products: a cohort study

Some long-term non-progressors (LTNPs) have decreasing CD4⁺ T cell counts and progress to AIDS. Exploring which subsets of CD4⁺ T cell decreasing and the determinants associated with the decay in these patients w...

Authors: Ling Xu, Yubin Liu, Xiaojing Song, Yanling Li, Yang Han, Ting Zhu, Wei Cao and Taisheng Li

Direct effects of mast cell proteases, tryptase and chymase, on bronchial epithelial integrity proteins and anti-viral responses

Mast cells (MCs) are known to contribute to both acute and chronic inflammation. Bronchial epithelial cells are the first line of defence against pathogens and a deficient anti-viral response has been suggeste...

Authors: Sangeetha Ramu, Hamid Akbarshahi, Sofia Mogren, Frida Berlin, Samuel Cerps, Mandy Menzel, Morten Hvidtfeldt, Celeste Porsbjerg, Lena Uller and Cecilia K. Andersson

Glycyrrhizin improves the pathogenesis of psoriasis partially through IL-17A and the SIRT1-STAT3 axis

The anti-inflammatory effect of glycyrrhizin has been widely recognized, while the specific mechanism of glycyrrhizin in psoriasis remains poorly understood.

Authors: Huang Qiong, Ling Han, Nanxue Zhang, Huyan Chen, Kexiang Yan, Zhenghua Zhang, Ying Ma and Jinhua Xu

Soluble cytotoxic T-lymphocyte–associated antigen 4 (sCTLA-4) as a potential biomarker for diagnosis and evaluation of the prognosis in Glioma

The cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) is widely considered as a pivotal immune checkpoint molecule to suppress antitumor immunity. However, the significance of soluble CTLA-4 (sCTLA-4) remai...

Authors: Jiajia Liu, Xiaoyi Tian, Yan Wang, Xixiong Kang and Wenqi Song

Macrophage mediated recognition and clearance of Borrelia burgdorferi elicits MyD88-dependent and -independent phagosomal signals that contribute to phagocytosis and inflammation

Macrophages play prominent roles in bacteria recognition and clearance, including Borrelia burgdorferi (Bb), the Lyme disease spirochete. To elucidate mechanisms by which MyD88/TLR signaling enhances clearance of...

Authors: Sarah J. Benjamin, Kelly L. Hawley, Paola Vera-Licona, Carson J. La Vake, Jorge L. Cervantes, Yijun Ruan, Justin D. Radolf and Juan C. Salazar

Selenium-related nutritional status in patients with common variable immunodeficiency: association with oxidative stress and atherosclerosis risk

Common variable immunodeficiency (CVID) is an inborn errors of immunity, that leads to recurrent chronic infections and autoimmune/ inflammatory diseases and neoplasms. It is considered that these condition is...

Authors: Itana Gomes Alves Andrade, Fabíola Isabel Suano de Souza, Fernando Luiz Affonso Fonseca, Carolina Sanchez Aranda and Roseli Oselka Saccardo Sarni

TREM2 promotes natural killer cell development in CD3⁻CD122⁺NK1.1⁺ pNK cells

Triggering receptor expressed on myeloid cells 2 (TREM2) signaling is considered to regulate anti-inflammatory responses in macrophages, dendritic cell maturation, osteoclast development, induction of obesity,...

Authors: Hwa-Youn Lee, Eun-Hee Lee, Jawoon Yi, Kon-Young Ji, Su-Man Kim, Ha-Rim Choi, Su-Min Yee, Hyung-Sik Kang and Eun-Mi Kim

Circular RNA circFADS2 is overexpressed in sepsis and suppresses LPS-induced lung cell apoptosis by inhibiting the maturation of miR-15a-5p

Circular RNA circFADS2 plays protective roles in LPS-induced inflammation, which promotes sepsis, suggesting its involvement in sepsis.

Authors: Xiaoyang Hong, Shuanglei Li, Jie Wang, Zhe Zhao and Zhichun Feng

Type 2 and type 3 innate lymphoid cells at the maternal-fetal interface: implications in preterm birth

Preterm birth (PTB) is one of the major causes of neonatal morbidity and mortality worldwide. It is commonly accepted that the act of giving birth is the final step in a proinflammatory signaling cascade, orch...

Authors: João Mendes, Paulo Rodrigues-Santos, Ana Luísa Areia, Jani-Sofia Almeida, Vera Alves, Manuel Santos-Rosa and Anabela Mota-Pinto

Predicting the allergenicity of legume proteins using a PBMC gene expression assay

Food proteins differ in their allergenic potential. Currently, there is no predictive and validated bio-assay to evaluate the allergenicity of novel food proteins. The objective of this study was to investigat...

Authors: Mark Smits, Marjolein Meijerink, Thuy-My Le, André Knulst, Aard de Jong, Martinus Petrus Maria Caspers, Everton Souto Lima, Lilia Babé, Gregory Ladics, Scott McClain, Geert Houben and Kitty Verhoeckx

Blood CD3-(CD56 or 16)+ natural killer cell distributions are heterogeneous in healthy adults and suppressed by azathioprine in patients with ANCA-associated vasculitides

Cytotoxic Natural Killer (NK) cells are increasingly recognized as a powerful tool to induce targeted cell death in cancer and autoimmune diseases. Still, basic blood NK cell parameters are poorly defined. The...

Authors: Wolfgang Merkt, Ulrich Salzer, Jens Thiel, Ilona Jandova, Raoul Bergner, Ana C. Venhoff and Nils Venhoff