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1171 result(s) for 'immunology' within BMC Immunology

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  1. The RATE tool was recently developed to computationally infer the HLA restriction of given epitopes from immune response data of HLA typed subjects without additional cumbersome experimentation.

    Authors: Sinu Paul, Cecilia S. Lindestam Arlehamn, Veronique Schulten, Luise Westernberg, John Sidney, Bjoern Peters and Alessandro Sette
    Citation: BMC Immunology 2017 18(Suppl 1):20
    Content type: Research Published on:

    This article is part of a Supplement: Volume 18 Supplement 1

  2. Triggering receptors expressed on myeloid cells (Trem) proteins are a family of cell surface receptors used to control innate immune responses such as proinflammatory cytokine production in mice. Trem genes be...

    Authors: Jun Kasamatsu, Mengyao Deng, Masahiro Azuma, Kenji Funami, Hiroaki Shime, Hiroyuki Oshiumi, Misako Matsumoto, Masanori Kasahara and Tsukasa Seya
    Citation: BMC Immunology 2016 17:9
    Content type: Research article Published on:

  3. Scavenger receptor A (SRA) is expressed predominantly in phagocytic cells playing an essential role in the host immune defense against invading microorganisms. Our previous study reported the presence of SRA i...

    Authors: Ying Chen, Zuxiong Huang, Di Ma, Liqian Chen, Qintao Lai, Xuan Huang, Jia Zhou, Xiaoyong Zhang, Qiang Ma, Zhengliang Chen and Daming Zuo
    Citation: BMC Immunology 2015 16:29
    Content type: Research article Published on:

  4. As a factor contributing to the tumor cell drug resistance, tumor microenvironment (TME) is being paid increasingly attention. However, the drug resistance of malignantly transformed cells in TME has rarely be...

    Authors: Xifeng Fei, Anqi Wang, Delin Wang, Xan Meng, Jiawei Ma, Lei Hong, Ruwei Qin, Aidong Wang, Jun Dong, Qiang Huang and Zhimin Wang
    Citation: BMC Immunology 2018 19:7
    Content type: Research article Published on:

  5. Previously, we demonstrated up-regulated activated CD4+ and CD8+ T lymphocytes as well as up-regulated cytotoxic NK cells in the blood of patients with idiopathic recurrent miscarriage. In the present study, w...

    Authors: Li Zhu, Mostafa Aly, Ruben Jeremias Kuon, Bettina Toth, Haihao Wang, Hristos Karakizlis, Rolf Weimer, Christian Morath, Eman Ibrahim, Naruemol Ekpoom, Gerhard Opelz and Volker Daniel
    Citation: BMC Immunology 2019 20:10
    Content type: Research article Published on:

  6. Capparis Spinosa L. is an aromatic plant growing wild in dry regions around the Mediterranean basin. Capparis Spinosa was shown to possess several properties such as antioxidant, antif...

    Authors: Mouna Moutia, Khadija El Azhary, Anass Elouaddari, Abdellah Al Jahid, Jamal Jamal Eddine, Fouad Seghrouchni, Norddine Habti and Abdallah Badou
    Citation: BMC Immunology 2016 17:26
    Content type: Research article Published on:

  7. Eosinophils are innate immune cells present in the intestine during steady state conditions. An intestinal eosinophilia is a hallmark of many infections and an accumulation of eosinophils is also observed in the ...

    Authors: Ruth Forman, Michael Bramhall, Larisa Logunova, Marcus Svensson-Frej, Sheena M. Cruickshank and Kathryn J. Else
    Citation: BMC Immunology 2016 17:12
    Content type: Research article Published on:

  8. Immunobiotic Lactobacillus jensenii TL2937 modulates porcine mononuclear phagocytes from Peyer’s patches (PPMPs) and induces a differential production of pro- and anti-inflammatory cytokines in response to Toll-l...

    Authors: Kohichiro Tsukida, Takuya Takahashi, Hikaru Iida, Paulraj Kanmani, Yoshihito Suda, Tomonori Nochi, Shuichi Ohwada, Hisashi Aso, Sou Ohkawara, Seiya Makino, Hiroshi Kano, Tadao Saito, Julio Villena and Haruki Kitazawa
    Citation: BMC Immunology 2016 17:21
    Content type: Research article Published on:

  9. Acute cellular rejection (ACR) is associated with complications after kidney transplantation, such as graft dysfunction and graft loss. Early risk assessment is therefore critical for the improvement of transp...

    Authors: Nicole Wittenbrink, Sabrina Herrmann, Arturo Blazquez-Navarro, Chris Bauer, Eric Lindberg, Kerstin Wolk, Robert Sabat, Petra Reinke, Birgit Sawitzki, Oliver Thomusch, Christian Hugo, Nina Babel, Harald Seitz and Michal Or-Guil
    Citation: BMC Immunology 2019 20:11
    Content type: Research article Published on:

  10. Most monoclonal antibodies against mouse antigens have been derived from rat spleen-mouse myeloma fusions, which are valuable tools for purposes ranging from general laboratory reagents to therapeutic drugs, a...

    Authors: Qin Chen, Shengping Qiu, Huanhuan Li, Chaolong Lin, Yong Luo, Wenfeng Ren, Yidi Zou, Yale Wang, Ninghshao Xia and Chenghao Huang
    Citation: BMC Immunology 2018 19:35
    Content type: Methodology article Published on:

  11. Lupus nephritis (LN) is a common complication of systemic lupus erythematosus that presents a high risk of end-stage renal disease. In the present study, we used CIBERSORT and gene set enrichment analysis (GSE...

    Authors: Yiling Cao, Weihao Tang and Wanxin Tang
    Citation: BMC Immunology 2019 20:37
    Content type: Research article Published on:

  12. Although a safe and effective yellow fever vaccine was developed more than 80 years ago, several issues regarding its use remain unclear. For example, what is the minimum dose that can provide immunity against...

    Authors: Carla R. B. Bonin, Guilherme C. Fernandes, Rodrigo W. dos Santos and Marcelo Lobosco
    Citation: BMC Immunology 2018 19:15
    Content type: Research article Published on:

  13. Patients with chronic hepatitis B virus infection (CHB) usually mount a modest T cell response against HBV epitopes. In order to determine immunogenic epitopes of HBV recognized by HBV-specific T cells, previo...

    Authors: Nanna-Sophie Brinck-Jensen, Thomas Vorup-Jensen, Peter Derek Christian Leutscher, Christian Erikstrup and Eskild Petersen
    Citation: BMC Immunology 2015 16:65
    Content type: Research article Published on:

  14. The Haemophilus influenzae type b (Hib) conjugate vaccine has been widely used in children to prevent invasive Hib disease because of its strong immunogenicity and antibody response induction relative to the caps...

    Authors: Jing Tang, Ying Zhang, Xiaolong Zhang, Yun Liao, Yongrong Wang, Shengjie Ouyang, Yanchun Che, Miao Xu, Jing Pu, Qi Shen, Zhanlong He, Qiang Ye and Qihan Li
    Citation: BMC Immunology 2018 19:4
    Content type: Research Article Published on:

  15. Circulating follicular helper T (Tfh) cells are a heterogeneous population of CD4+ helper T cells that promotes pathogenic immune responses in autoimmune diseases. In this study, we examined the status of differe...

    Authors: Deying Liu, Jinxiang Liu, Jinghua Wang, Congcong Liu, Sirui Yang and Yanfang Jiang
    Citation: BMC Immunology 2016 17:40
    Content type: Research article Published on:

  16. Lipopolysaccharide (LPS) induces acute liver injury and the complex mechanisms include the activation of toll like receptor 4 (TLR4) signaling pathway in many species. However, immuno-pathological changes duri...

    Authors: Xi-Yao Huang, Abdur Rahman Ansari, Hai-Bo Huang, Xing Zhao, Ning-Ya Li, Zhi-Jian Sun, Ke-Mei Peng, Juming Zhong and Hua-Zhen Liu
    Citation: BMC Immunology 2017 18:12
    Content type: Research article Published on:

  17. Systemic inflammation and the fever response to pathogens are coordinately regulated by IL-6 and IL-1β. We previously showed that CEACAM1 regulates the LPS driven expression of IL-1β in murine neutrophils thro...

    Authors: Zhifang Zhang, Deirdre La Placa, Tung Nguyen, Maciej Kujawski, Keith Le, Lin Li and John E. Shively
    Citation: BMC Immunology 2019 20:7
    Content type: Research article Published on:

  18. Blood platelets are first aimed at ensuring primary hemostasis. Beyond this role, they have been acknowledged as having functions in the maintenance of the vascular arborescence and, more recently, as being al...

    Authors: Adrien Chabert, Hind Hamzeh-Cognasse, Bruno Pozzetto, Fabrice Cognasse, Mirta Schattner, Ricardo M Gomez and Olivier Garraud
    Citation: BMC Immunology 2015 16:26
    Content type: Review Published on:

  19. In this study, seven adjuvants were compared for use with Plasmodium falciparum DiCo-Apical Membrane Antigen 1 (Pf-DiCo-AMA1), with the aim to identify an ideal adjuvant which yields high antibody titres and pote...

    Authors: Sumera Younis, Bart W. Faber, Clemens H.M. Kocken and Edmond J. Remarque
    Citation: BMC Immunology 2019 20:25
    Content type: Research article Published on:

  20. Ethiopia initiated antiretroviral therapy early in 2005. Managing and detecting antiretroviral treatment response is important to monitor the effectiveness of medication and possible drug switching for low imm...

    Authors: Hadush Negash, Haftom Legese, Mebrahtu Tefera, Fitsum Mardu, Kebede Tesfay, Senait Gebresilasie, Berhane Fseha, Tsega Kahsay, Aderajew Gebrewahd and Brhane Berhe
    Citation: BMC Immunology 2019 20:45
    Content type: Research article Published on:

  21. Type 1 diabetes is an autoimmune disease caused by T cell-mediated destruction of the insulin-producing β-cells in the pancreas. Therefore, approaches that effectively halt the pathogenic T cell response are p...

    Authors: Cristina Vazquez-Mateo, Justin Collins, Michelle Fleury and Hans Dooms
    Citation: BMC Immunology 2017 18:18
    Content type: Research article Published on:

  22. Weighted Gene Co-expression Network analysis, a powerful technique used to extract co-expressed gene pattern from mRNA expression data, was constructed to infer common immune strategies used by cattle in respo...

    Authors: Hamid Beiki, Abbas Pakdel, Ardeshir Nejati Javaremi, Ali Masoudi-Nejad and James M. Reecy
    Citation: BMC Immunology 2018 19:2
    Content type: Research article Published on:

  23. Macrophage migration inhibitory factor (MIF) is a cytokine that shares many activities with other pro-inflammatory cytokines in primary glomerulonephritis (GN). This study assesses the influence of immunosuppr...

    Authors: Rafał Zwiech
    Citation: BMC Immunology 2015 16:47
    Content type: Research article Published on:

  24. The mouse strain BALB/c deficient in IL-1 receptor antagonist protein (Il-1ra) develops spontaneous arthritis disease (SAD) while the strain DBA/1 IL1rn -/- with the same deficiency doe...

    Authors: Xiaoyun Liu, Yan Jiao, Yanhong Cao, Nan Deng, Yonghui Ma, Karen A. Hasty, Andrew Kang, Hong Chen, John M. Stuart and Weikuan Gu
    Citation: BMC Immunology 2016 17:25
    Content type: Research article Published on:

  25. Lung inflammation is a major consequence of the systemic inflammatory response caused by severe sepsis. Increased migration of γδ T lymphocytes into the lungs has been previously demonstrated during experiment...

    Authors: Maria Fernanda de Souza Costa, Catarina Bastos Trigo de Negreiros, Victor Ugarte Bornstein, Richard Hemmi Valente, José Mengel, Maria das Graças Henriques, Claudia Farias Benjamim and Carmen Penido
    Citation: BMC Immunology 2015 16:36
    Content type: Research article Published on:

  26. Excessive and inappropriate immune responses are the hallmark of several autoimmune disorders, including the inflammatory bowel diseases (IBD): Crohn’s disease (CD) and ulcerative colitis (UC). A complex etiol...

    Authors: Jeremy S Schaefer, Taraq Attumi, Antone R Opekun, Bincy Abraham, Jason Hou, Harold Shelby, David Y Graham, Charles Streckfus and John R Klein
    Citation: BMC Immunology 2015 16:5
    Content type: Research article Published on:

  27. CD4+CD25+ regulatory T (Treg) cells suppress tumor immunity by inhibiting immune cells. Manipulation of Treg cells represents a new strategy for cancer treatment. Zoledronic acid (ZA), a nitrogen-containing bisph...

    Authors: Hsien Liu, Shih-Han Wang, Shin-Cheh Chen, Ching-Ying Chen, Jo-Lin Lo and Tsun-Mei Lin
    Citation: BMC Immunology 2016 17:45
    Content type: Research article Published on:

  28. Antibodies against Region III-V of the erythrocyte binding antigen (EBA) 175 (EBA175RIII-V) have been suggested to provide protection from malaria in a natural infection. However, the quality and quantity of n...

    Authors: L. E. Amoah, H. B. Abagna, K. Akyea-Mensah, A. C. Lo, K. A. Kusi and B. A. Gyan
    Citation: BMC Immunology 2018 19:34
    Content type: Research article Published on:

  29. Necrosis of alveolar macrophages following Mycobacterium tuberculosis infection has been demonstrated to play a vital role in the pathogenesis of tuberculosis. Our previous study demonstrated that Wnt/β-catenin s...

    Authors: Xiaoling Wu, Guangcun Deng, Min Li, Yong Li, Chunyan Ma, Yujiong Wang and Xiaoming Liu
    Citation: BMC Immunology 2015 16:16
    Content type: Research article Published on:

  30. A significant barrier to organ transplantation is the cellular rejection that occurs and mediated by antibodies, T cells, and innate immune cells. This study was aimed to determine the number of CD4+CD25+Foxp3+ T...

    Authors: Liang Ma, Huimao Zhang, Kebang Hu, Guoyue Lv, Yaowen Fu, Desalegn Admassu Ayana, Pingwei Zhao and Yanfang Jiang
    Citation: BMC Immunology 2015 16:56
    Content type: Research article Published on:

  32. Resident macrophages (Mø) originating from yolk sac Mø and/or foetal monocytes colonise tissues/organs during embryonic development. They persist into adulthood by self-renewal at a steady state, independent o...

    Authors: Kazushige Ogawa, Mayu Tsurutani, Aya Hashimoto and Miharu Soeda
    Citation: BMC Immunology 2019 20:34
    Content type: Methodology article Published on:

  33. Validation of biomarkers for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) across data sets has proven disappointing. As immune signature may be affected by many factors, our objective was to exp...

    Authors: Lindsey Russell, Gordon Broderick, Renee Taylor, Henrique Fernandes, Jeanna Harvey, Zachary Barnes, AnneLiese Smylie, Fanny Collado, Elizabeth G. Balbin, Ben Z. Katz, Nancy G. Klimas and Mary Ann Fletcher
    Citation: BMC Immunology 2016 17:3
    Content type: Research article Published on:

  34. Although histone methyltransferases EZH2 has been proved to have significant regulatory effect on the immune rejection after hematopoietic stem cell transplantation, its role in solid-organ transplantation rem...

    Authors: Long Li, Yi Zhang, Ming Xu, Ruiming Rong, Jina Wang and Tongyu Zhu
    Citation: BMC Immunology 2016 17:41
    Content type: Research article Published on:

  35. Type 1 diabetes (T1D) is thought to be an autoimmune disease driven by anti-islet antigen responses and mediated by T-cells. Recent published data suggests that T-cell reactivity to modified peptides, effectiv...

    Authors: John Sidney, Jose Luis Vela, Dave Friedrich, Ravi Kolla, Matthias von Herrath, Johnna D. Wesley and Alessandro Sette
    Citation: BMC Immunology 2018 19:12
    Content type: Research article Published on:

  36. Mast cells are hematopoietically derived cells that play a role in inflammatory processes such as allergy, as well as in the immune response against pathogens by the selective and rapid release of preformed an...

    Authors: Valéria Cintra Barbosa-Lorenzi, Nerry Tatiana Cecilio, Patricia Andressa de Almeida Buranello, Maria Cristina Pranchevicius, Maria Helena S. Goldman, Gabriela Pereira-da-Silva, Maria Cristina Roque-Barreira, Maria Célia Jamur and Constance Oliver
    Citation: BMC Immunology 2016 17:22
    Content type: Research article Published on:

  37. Tristetraprolin (TTP) is an RNA binding protein that plays a critical role in regulating proinflammatory immune responses by destabilizing target mRNAs via binding to their AU-rich elements (AREs) in the 3′-UT...

    Authors: Yafang Tu, Xiongfei Wu, Fengyun Yu, Jianzhong Dang, Juan Wang, Yaxun Wei, Zhitao Cai, Zhipeng Zhou, Wenliang Liao, Lian Li and Yi Zhang
    Citation: BMC Immunology 2019 20:13
    Content type: Research article Published on:

  38. Myeloid derived suppressor cells (MDSCs) present a significant obstacle to cancer immunotherapy because they dampen anti-tumor cytotoxic T cell responses. Previous groups, including our own, have reported on t...

    Authors: Andrea J. Luker, Laura J. Graham, Timothy M. Smith Jr, Carmen Camarena, Matt P. Zellner, Jamie-Jean S. Gilmer, Sheela R. Damle, Daniel H. Conrad, Harry D. Bear and Rebecca K. Martin
    Citation: BMC Immunology 2020 21:8
    Content type: Research article Published on:

  39. To investigate the impact of miRNA (microRNA) on hepatic oxidative stress damage under the human mesenchymal stem cell conditioned medium (MSC-CM) and explore the roles of the beta-1 adrenergic receptor (ADRB1...

    Authors: Xuejing Xu, Dong Li, Xue Li, Qing Shi and Xiuli Ju
    Citation: BMC Immunology 2017 18:51
    Content type: Research article Published on:

  40. Recently, the immunostimulatory roles of chemotherapeutics have been increasingly revealed, although bone marrow suppression is still a common toxicity of chemotherapy. While the numbers and ratios of differen...

    Authors: Yanhong Wu, Zhenling Deng, Huiru Wang, Wenbo Ma, Chunxia Zhou and Shuren Zhang
    Citation: BMC Immunology 2016 17:29
    Content type: Research article Published on:

  42. The spleen is an important site for hematopoiesis. It supports development of myeloid cells from bone marrow-derived precursors entering from blood. Myeloid subsets in spleen are not well characterised althoug...

    Authors: Ying-Ying Hey, Benjamin Quah and Helen C. O’Neill
    Citation: BMC Immunology 2017 18:4
    Content type: Research article Published on:

  43. Early diagnosis of bacterial sepsis in neonates is hampered by non-specific symptoms and the lack of rapid responding laboratory measures. The biomarker soluble CD14 subtype (sCD14-ST) seems promising in the d...

    Authors: Iris van Maldeghem, Charlotte M. Nusman and Douwe H. Visser
    Citation: BMC Immunology 2019 20:17
    Content type: Research article Published on:

  44. While tumor necrosis factor alpha (TNF-α) inhibitors (TNFi) and other biologics are very effective against autoimmune diseases, they can also cause infectious diseases. Therefore, it is important to clarify wh...

    Authors: Shoichi Fukui, Hideki Nakamura, Yoshiko Takahashi, Naoki Iwamoto, Hiroo Hasegawa, Katsunori Yanagihara, Tatsufumi Nakamura, Akihiko Okayama and Atsushi Kawakami
    Citation: BMC Immunology 2017 18:7
    Content type: Research article Published on:

  45. Mannose-binding lectin (MBL) is a key component of innate immunity. Low serum MBL levels, related to promoter polymorphism and structural variants, have been associated with an increased risk of infection. The...

    Authors: M. Puente, C. Fariñas-Alvarez, A. Moreto, P. Sánchez-Velasco, J. G. Ocejo-Vinyals and M. C. Fariñas
    Citation: BMC Immunology 2019 20:40
    Content type: Research article Published on:

  46. Inflammatory skin diseases such as atopic dermatitis and psoriasis represent a complex interaction between the skin and infiltrating immune cells, resulting in damage to the skin barrier and increased inflamma...

    Authors: Pauline Muscat, Karessa Mercado, Kathryn Payne, Hardip Chahal and Graham Jones
    Citation: BMC Immunology 2015 16:69
    Content type: Research article Published on:

  47. The adaptive immune system maintains a diversity of T cells capable of recognizing a broad array of antigens. Each T cell’s specificity for antigens is determined by its T cell receptors (TCRs), which together...

    Authors: Nathaniel D. Chu, Haixin Sarah Bi, Ryan O. Emerson, Anna M. Sherwood, Michael E. Birnbaum, Harlan S. Robins and Eric J. Alm
    Citation: BMC Immunology 2019 20:19
    Content type: Research article Published on:

  49. Polymorphisms in cytokine genes are known to influence cytokine levels, which may influence susceptibility to tuberculosis (TB) infection and disease. Differences in cytokine expression probably determine whet...

    Authors: Yi Hu, Linlin Wu, Dange Li, Qi Zhao, Weili Jiang and Biao Xu
    Citation: BMC Immunology 2015 16:8
    Content type: Research article Published on:

  50. Circulating follicular helper T (cTfh) cells are a specialized subset of CD4+ T cells that express the CXC-chemokine receptor 5 (CXCR5). These cells exhibit immune activities by inducing B cell differentiation an...

    Authors: Meng Xu, Yanfang Jiang, Jian Zhang, Yan Zheng, Deying Liu, Lishuang Guo and Sirui Yang
    Citation: BMC Immunology 2018 19:43
    Content type: Research article Published on:

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